Huafeng Wei, MD, PhDAssistant Professor of Anesthesiology and Critical Care
Attending Anesthesiologist
Department: Anesthesiology and Critical Care
Contact information
Department of Anesthesia and Critical Care
University of Pennsylvania 319A John Morgan Building 3620 Hamilton Walk Philadelphia, PA 19104-6112
Office: 215-662-3193
Fax: 215-349-5078 Email: weih@uphs.upenn.edu
Education:
Diploma (Medicine) Jining Medical School, Jining, China, 1982. MD (Medicine) Tongji Medical University, Wuhan, China, 1988. PhD (Pharmacology and Toxicology) George Washington University, Washington, DC, 1996.
Post-Graduate Training
Resident in Anesthesiology, Department of Anesthesia, Shandong Provincial Hospital, Jinan, China, 1982-1985. Postdoctural Fellow, Georgetown Institute for Cognitive and Computational Sciences (GICCS), Georgetown University Medical School, 1996-1997. IRTA Postdoctural Fellow in Molecular Neurobiology, National Institute of Mental Health, NIH, Bethesda, MD, 1997-1999. Transitional Internship, Presbyterian Medical Center, Philadelphia, PA, 1999-2000. Resident in Anesthesia, Hospital of the University of Pennsylvania, Philadelphia, PA, 2000-2003.
Certifications
Permanent linkBoard Certified, American Board of Anesthesiology (ABA), 2004. Description of Research ExpertiseNeuronal apoptosis: mechanism, relation to intracellular calcium, implication in neurodegenerative diseases and clinical anesthesia; volatile anesthetics and neurodegeneration; Anesthesia toxicity in Alzheimer's disease, Huntington's disease and during fetal surgery.High frequency jet ventilation Description of Clinical ExpertiseGeneral practice of anesthesia, Difficult airway management, Clinical use of high frequency jet ventilation (HFJV)Selected PublicationsWei, H, Xie, Z: Anesthesia, Calcium Homeostasis and Alzheimer's Disease. Current Alzheimer Reserach 6: 30-35, 2009.Baranov D, Bickler PE, Crosby GJ, Culley DJ, Eckenhoff MF, Eckenhoff RG, Hogan KJ, Jevtovic-Todorovic V, Palota´s A, Perouansky M, Planel E, Silverstein JH, Wei H, Whittington RA, Xie Z, Zuo Z: Consensus Statement: First International Workshop on Anesthetics and Alzheimer’s Disease. Anesthesia and Analgesia 108: 1627-30, 2009. Liang G, Wang Q, Li Y, Kang B, Eckenhoff MF, Eckenhoff RG, Wei H: A Presenilin-1 mutation renders neurons vulnerable to isoflurane toxicity. Anesthesia and Analgesia 106: 492-500, 2008. Yang H, Liang G, Hawkins B, Madesh M, Pierwola A, Wei H: Inhalational anesthetics induce cell damage by disruption of intracellular calcium homeostasis with different potencies. Anesthesiology 109: 243-50, August 2008. Wei H, Liang G, Yang H, Wang Q, Hawkins B, Madesh M, Wang S, Eckenhoff RG: The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors. Anesthesiology 108: 251-60, 2008. Li Y, Liang G,Wang S, Meng Q, Wang Q, Wei H: Effects of fetal exposure to isoflurane on postnatal memory and learning in rats. Neuropharmacology 53: 942-950, 2007. Wei H, Liang G, Yang H: Isoflurane preconditioning inhibited isoflurane-induced neurotoxicity. Neuroscience Letter 425: 59-62, 2007. Pan JZ, Wei H, Hecker JG, Tobias J, Eckenhoff RG, Eckenhoff MF : Rat Brain DNA Transcript Profile of Volatile Anesthetic Exposure. Pharmacogenetics and Genomics 16: 171-182, 2006. Wei, H: A novel endotracheal tube and methods to faciliate ventilation and placement in emergent airway management. Resuscitation. 70: 438-444, 2006. Hiroi, T, Wei, H, Hough, C, Leeds, P, Chuang, D-M: Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP 78 and Bcl-2. The Pharmacogenomics Joural Nature Publishing Group, Page: 1-10, January 2005. Wei H, Kang, B, Wei, W, liang, G, Meng QC, Li, Y, Eckenhoff, RG, : Isoflurane and Sevoflurane Affect Cell Sruvival and Bcl-2/Bax Ratio Differently. Brain Research. Elsevier, 1037: 139-147, 2005. Eckehnoff RG, Johansson JS, Wei H, Carnini A, Kang B, Wei W, Pidikiti R, Keller JM and Eckenhoff MF: Inhaled Anesthetic Enhancement of Amyloid-beta oligomerization and cytotoxicity. Anesthesiology. Lippincott Williams & Wilkins, Inc, 101(3): 703-9, September 2004. Senatorov, V.V., Ren, M., Kanai, H., Wei, H. and Chuang, D-M. : Short-term lithium treatment promotes neuronal survival and proliferation in rat striatum infused with quinolinic acid, an excitotoxic model of Huntington's disease. Molecular Psychiatry. Nature Publishing Group, Page: 1-15, 2004. Wei H, Qin, ZH, Senatorov VV, Wei W, Wang Y, Qian Y and Chuang DM: Lithium suppresses excitotoxicity-induced striatal lesions in a rat model of Huntington's disease. Neuroscience 106(3): 603-612, 2001. Wei H, Leeds P, Chen RW, Wei W, Leng Y, Bredesen DE and Chuang DM: Neuronal apoptosis induced by pharmacological concentrations of 3-Hydroxykynurenine: Characterization and protection by dantrolene and Bcl-2 overexpression. Journal of Neurochemistry 75: 81-90, 2000. Wei H, Leeds PR, Qian Y, Wei W, Chen RW, and Chuang DM: ß-amyloid peptide-induced death of PC 12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment. European Journal of Pharmacology 392: 117-123, 2000. Chen, R-W, Saunders PA, Wei H, Li Z, Seth P and Chuang DM: Involvement ofGlyceraldehyde-3Phosphate Dehydrogenase (GAPDH) and p53 in neuronal apoptosis: Evidence that GAPDH is upregulated by p53. The Journal of Neuroscience 19(21): 9654-9662, 1999. Wang S, Peretich K, Zhao Y, Liang G, Meng Q, Wei H: Anesthesia-induced neurodegeneration in fetal rat brains. Pediatric Research 66: 435-440, 2009. Wei H, Fiskum G, Rosenthal RE, and Perry DC: Non-NMDA glutamate receptor binding in canine brain after global cerebral ischemia and reperfusion. Molecular Chemical Neuropathology 29: 37-52, 1996. Wei H, Fiskum G, Rosenthal RE and Perry DC: Global cerebral ischemia and reperfusion alters NMDA receptor binding in canine brain. Molecular Chemical Neuropathology 30: 25-39, 1997. Liang, G, Ward, C, Peng, J, Zhao, Y, Huang, B, Wei, H. : Isoflurane Causes Greater Neurodegeneration than an Equivalent Exposure of Sevoflurane in the Developing Brains of Neonatal Mice. Anesthesiology Accepted, 2009. Wei H, Jin S, Ma l, Bi H, and Ba X: Experimental study of high frequency two-way jet ventilation. Critical Care Medicine 20: 420-423, 1992. Perry DC, Wei H, Rosenthal RE and Fiskum G: Autoradiographic analysis of L- and N-type voltage-dependent calcium channel binding in canine brain after global cerebral ischemia reperfusion. Brain Research 657: 65-72, 1994. Wei H, Wei W, Bredesen D, and Perry DC: Bcl-2 inhibits apoptosis induced by depletion of calcium from endoplasmic reticulum. Journal of Neurochemistry 70: 2305-2314, 1998. Wei H and Perry DC: Dantrolene is cytoprotective in two models of neuronal cell death. Journal of Neurochemistry 67(6): 2390-2398, 1996.
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