Department of Anesthesiology and Critical Care

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Gordon A. Barr, Ph.D.

Associate Professor of Psychology in Anesthesiology and Critical Care
Director, Section of Acute and Chronic Pain Medicine, Dept. Anesth. & CCM, Children's Hospital of Phialdelphia (CHOP)
James Battaglia Endowed Chair of Pediatric Pain Medicine, Dept. Anesth. & CCM, Children’s Hospital of Philadelphia (CHOP)
Department: Anesthesiology and Critical Care

Contact information
Abramson Research Building, Room 716D
Department of Anesthesiology and CCM
Children's Hospital of Philadelphia
Philadelphia, PA 19104
Office: 267-426-9722
Fax: 267-426-8128
Graduate Group Affiliations
Education:
B.A. (Psychology)
Dickinson College, 1969.
M.A.
Carnegie Mellon University, 1971.
Ph.D. (Psychology)
Carnegie Mellon University, 1975.
Post-Graduate Training
Postdoctoral Fellow, Neuropharmacology, Albert Einstein College of Medicine, 1975-1977.
Faculty Fellowship leave, Neuroanatomy and Neurobiology, Medical College of Pennsylvania, 1984-1985.
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Description of Research Expertise

I study transitions during early development. Transitions are important developmental epochs during which time there are substantial changes in how infants/children/adolescents process information. I am particularly interested in mechanisms of of stress, pain and recovery from damage to the nervous system from that developmental perspective. I study models of acute and chronic pain, infant-mother attachment, the therapeutic and adverse effects of analgesics, especially opiates, and spinal cord injury and recovery from injury. Our lab develops and uses sophisticated behavioral assays in young animals in conjunction with a number of anatomical and neurochemical assays to understand mechanisms by which these transitions occur.

Selected Publications

Barr G A, Wang S: Analgesia induced by localized injection of opiate peptides into the brain of infant rats. European journal of Pain 17: 676-91, 2013.

Murray Marion, Santi Lauren, Monaghan Rebecca, Houle John D, Barr Gordon A: Peripheral nerve graft with immunosuppression modifies gene expression in axotomized CNS neurons. The Journal of Comparative Neurology 519(17): 3433-55, Dec 2011.

Hunter, D.A., Barr, G.A., Amador, N.J., Shivers, K-Y., Kemen, L., Kreiter, C.M., Jenab, J., Inturrisi, C.E., Quinones-Jenab, V.: Estradiol-induced antinociceptive responses on formalin-induced nociception are independent of COX and HPA activation. Synapse 65(7): 643-651, Jul 2011.

Chan, T., Kyere, K., Davis, B.R., Shemyakin, A., Kabitzke, P.A., Shair, H.N., Barr, G.A., Wiedenmayer, C.P.: The role of the medial prefrontal cortex in innate fear regulation in infants, juveniles, and adolescents. Journal of Neuroscience 31(13): 4991-4999, Mar 2011.

Hunter, D.A., Barr, G.A., Shivers, K-Y., Amador, N.J., Jenab, J., Inturrisi, C.E., Quinones-Jenab, V.: Interactions of estradiol and NSAIDS on carrageenan-induced hyperalgesia. Brain Research 382: 181-188, Mar 2011.

Barr Gordon A: Formalin-induced c-fos expression in the brain of infant rats. The Journal of Pain : official journal of the American Pain Society 12(2): 263-71, Feb 2011.

Barr Gordon A, Moriceau Stephanie, Shionoya Kiseko, Muzny Kyle, Gao Puhong, Wang Shaoning, Sullivan Regina M: Transitions in infant learning are modulated by dopamine in the amygdala. Nature Neuroscience 12(11): 1367-9, Nov 2009.

McPhie, A.A., Barr, G.A.: Regional expression of the cellular protein fos induced by morphine withdrawal in the 7-day old rat. Developmental Psychobiology 51: 544-552, 2009.

Butkevich, I.P., Barr, G.A., Vershinina, E.A.: Sex differences in formalin-induced pain in prenatally stressed infant rats. European Journal of Pain 11(8): 888-894, Nov 2007.

King Tamara E, Barr Gordon A: Spinal cord ionotropic glutamate receptors function in formalin-induced nociception in preweaning rats. Psychopharmacology 192(4): 489-98, Jul 2007.

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Last updated: 05/30/2014
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