Department of Anesthesiology and Critical Care

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Ganesh S. Moorthy, PhD

Research Assistant Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
The Children's Hospital of Philadelphia
Department of Anesthesiology and Critical Care Medicine
Bioanalytical Core Laboratory, The Center for Clinical Pharmacology
4012 Colket Translational Research Building
3501 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215 590 0142
Fax: 267 425 0025
Lab: 215 590 0142
Education:
B.Sc. (Chemistry)
Bharathiyar University, Coimbatore, India , 1988.
M.Sc. (Chemistry)
Indian Institute of Technology, Madras, India , 1990.
Ph.D. (Chemistry)
Case Western Reserve University, 1997.
Post-Graduate Training
Junior Research Fellow of Chemistry, Indian Institute of Technology, Madras, India, 1990-1992.
Fellow of Cell Biology, The Cleveland Clinic Foundation, Cleveland, Ohio, 1995-1997.
Post-Graduate Researcher of Medicine/Cardiology, University of California Los Angeles, Los Angeles, California, 1997-1999.
Certifications
CITI Program: The Protection of Human Subjects and HIPAA for Research, 2010.
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Description of Research Expertise

Bioanalytical Chemistry and Pharmacokinetics

The primary focus of my research is working with physicians and scientists to solve complex problems in pediatric drug development. Our laboratory is equipped with UPLC-MS/MS and UHPLC-MS/MS systems and Watson LIMS. We specialize in method development, validation and sample analysis for pediatric and adult clinical trials. Our clinical research is focused on the pharmacokinetic analysis of dexmedetomidine, midazolam, morphine, ketamine, cefepime, cefazolin, voriconazole, efavirenz, tenofovir, and cannabinoids. We also have an expertise in the fast assay development for preclinical studies in various biological matrices. Our preclinical research involves the pharmacokinetic analysis of oxycodone, SN-38, irinotecan, vemurafenib, and secoisolariciresinol diglucoside. We continue to evaluate and utilize new tools and microsampling technologies to facilitate preclinical, translational and clinical research.

Selected Publications

Nguyen F, Alferiev I, Guan P, Guerrero DT, Kolla V, Moorthy GS, Chorny M, Brodeur GM: Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model. Clin Cancer Res. 24(11): 2585-2593, June 2018 Notes: doi: 10.1158/1078-0432.CCR-17-3811.

Vujkovic M, Bellamy SL, Zuppa AF, Gastonguay MR, Moorthy GS, Ratshaa B, Han X, Steenhoff AP, Mosepele M, Strom BL, Bisson GP, Aplenc R, Gross R: Polymorphisms in cytochrome P450 are associated with extensive efavirenz pharmacokinetics and CNS toxicities in an HIV cohort in Botswana. Pharmacogenomics J. June 2018 Notes: doi: 10.1038/s41397-018-0028-2. [Epub ahead of print]

Moorthy GS, Vedar C, Zane N, Prodell JL, DiLiberto MA, and Zuppa AF: A Microsampling Assay for Analysis of Cannabinoids in Human Whole Blood The American Society for Mass Spectrometry Annual Conference June 2018 Notes: June 3 -7, San Diego, CA.

Tran BD, Moorthy GS, Zuppa AF: Ketamine and norketamine stability in whole blood at ambient and 4°C conditions. Biomed Chromatogr 32(3): doi: 10.1002/bmc.4104, March 2018.

Moorthy GS, Vedar C, Zane N, Prodell JL, and Zuppa AF: Development and Validation of a Volumetric Absorptive Microsampling Assay for Analysis of Voriconazole and Voriconazole N-Oxide in Human Whole Blood. The American Society for Clinical Pharmacology & Therapeutics 2018 Annual Meeting, March 2018 Notes: Late Breaking Poster PII-002, March 21 - 24, Orlando, FL.

Elia J, Ungal G, Kao C, Ambrosini A, De Jesus-Rosario N, Larsen L, Chiavacci R, Wang T, Kurian C, Titchen K, Sykes B, Hwang S, Kumar B, Potts J, Davis J, Malatack J, Slattery E, Moorthy G, Zuppa A, Weller A, Byrne E, Li YR, Kraft WK, Hakonarson H: Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling. Nat Commun 9(1): 4, Jan 2018.

Chikara S, Mamidi S, Sreedasyam A, Chittem K, Pietrofesa R, Zuppa A, Moorthy G, Dyer N, Christofidou-Solomidou M, Reindl KM: Flaxseed Consumption Inhibits Chemically Induced Lung Tumorigenesis and Modulates Expression of Phase II Enzymes and Inflammatory Cytokines in A/J Mice. Cancer Prev Res (Phila) 11(1): 27-37, Jan 2018.

Moorthy GS, Jogiraju H, Zuppa AF. : Development and validation of a sensitive assay for analysis of midazolam, free and conjugated 1-hdroxymidazolam and 4-hydroxymidazolam in pediatric plasma: Application to Pediatric Pharmacokinetic Study. J Chromatogr B Analyt Technol Biomed Life Sci 1067: 1-9, Nov 2017.

Gross R, Bellamy SL, Ratshaa BR, Han X, Vujkovic M, Aplenc R, Steenhoff AP, Mosepele M, Moorthy GS, Zuppa AF, Strom BL, Bisson GP: CYP2B6 Genotypes and Early Efavirenz-based HIV Treatment Outcomes in Botswana. JAIDS 31(15): 2107-2113, Sept 2017.

Giaccone A, Zuppa AF, Sood B, Cohen M, O’Byrne M, Moorthy GS, Mathur A, Kirpalani H. : Milrinone Pharmacokinetics and Pharmacodynamics in Neonates with Persistent Pulmonary Hypertension of the Newborn. Am J Perinatol. 34(8): 749-758, July 2017.

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Last updated: 06/03/2018
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