Department of Anesthesiology and Critical Care

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Scott L Weiss, MD, MSCE, FCCM

Assistant Professor of Anesthesiology and Critical Care at the Hospital of the University of Pennsylvania and the Children's Hospital of Philadelphia
Faculty/Core Member, Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia
Department: Anesthesiology and Critical Care

Contact information
The Children's Hospital of Philadelphia
Department of Anesthesiology and Critical Care
3401 and Civic Center Blvd
6 Wood, Room 6307
Philadelphia, PA 19104
Office: 215-590-5505
Fax: 215-590-4735
BS (Human Development)
Cornell University, 2000.
MD (Medicine)
Harvard Medical School, 2004.
MSCE (Master of Science in Clinical Epidemiology)
Perelman School of Medicine, University of Pennsylvania, 2014.
Post-Graduate Training
Intern, Pediatrics, Children's Hospital Boston, Harvard Medical School, Boston, MA, 2004-2005.
Resident, Pediatrics, Children's Hospital Boston, Harvard Medical School, Boston, MA, 2005-2007.
Fellowship, Pediatric Critical Care Medicine, Children's Memorial Hospital, Northwestern Feinberg School of Medicine, (now Anne & Robert H. Lurie Children's Hospital of Chicago) Chicago, IL, 2008-2011.
Basic Life Support (BLS), 1997.
Pediatric Advanced Life Support (PALS), 2004.
Advanced Cardiovascular Life Support (ACLS), 2004.
Neonatal Resuscitation Program, 2005.
American Board of Pediatrics, 2007.
Advanced Trauma Life Support (ATLS), 2011.
American Board of Pediatrics, Pediatric Critical Care Medicine, 2012.
Research Mentor Training, University of Pennsylvania Perelman School of Medicine, 2018.
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Description of Other Expertise

Co-founder, CHOP Pediatric Sepsis Program (

Description of Research Expertise

Pediatric sepsis, bienergetic failure, microcirculatory dysfunction, mitochondrial dysfunction, biomarkers

Selected Publications

Whitney J, Yehya N, Weiss SL: IL-6 at sepsis recognition is associated with poor functional outcome. 25th Pediatric Critical Care Colloquium October 2018 Notes: Oral presentation, 25th Pediatric Critical Care Colloquium, 2018 October 5-7, Baltimore, MD.

Weiss SL: Five important things to know about pediatric sepsis. Society of Critical Care Medicine Critical Connections 17(4): 8, August/September 2018 Notes: Invited editorial.

Idris I, Alpern E, Angus D, Friedrich M, Kissoon N, Lemeshow S, Levy M, Parker M, Terry K, Watson S, Weiss SL, Zimmerman J, Seymour C: One-hour bundle and mortality during mandated care for pediatric sepsis. JAMA 320(4): 358-367, July 2018.

Weiss SL, Zhang D, Bush J, Star J, Kilbaugh T, Deutschman CS, Becker L, McGowan FX, Wallace D: Decreased immune cell mitochondrial respiration is not associated with organ dysfunction or early death in pediatric sepsis. Shock 49(Suppl 1)(Supplement 1): 131, June 2018 Notes: Poster presented at Shock Society 2018 Annual Meeting, 2018 June 9-12, Scottsdale, AZ.

Fitzgerald JC, Weiss SL: Taking meaning from numbers in regional epidemiologic data [Invited editorial] The Lancet Child & Adolescent Health Page: 381-382, June 2018.

Glau DL, Conlon TW, Himebauch AS, Yehya N, Weiss SL, Berg RA, Nishisaki A: Progressive diaphragm atrophy in pediatric acute respiratory failure. Pediatric Critical Care Medicine 19(5): 406-411, May 2018.

Walker S, Conlon TW, Zhang B, Mensinger J, Fitzgerald JC, Himebauch A, Glau C, Nishisaki A, Ranjit S, Nadkarni VM, Weiss SL: Application of clinical signs to differentiate warm versus cold pediatric septic shock. Pediatric Academic Societies Meeting May 2018 Notes: Poster Presentation at PAS Meeting, May 2018, Toronto, Canada.

Shelov E, Woods-Hill C, Kaminski S, Bruhn R, Biedron L, Hadley S, Weiss SL, Fitzgerald JC. : Using order and administration patterns to improve time to antibiotic administration in a Pediatric ICU. Philadelphia Quality and Patient Safety Day May 2018 Notes: Abstract presented at The Children’s Hospital of Philadelphia Quality and Patient Safety Day, Philadelphia, PA, May 15, 2018.

Signoff JK, Fitzgerald JC, Teachey DT, Balamuth F, Weiss SL: Hypofibrinogenemia is associated with poor outcome and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome in pediatric severe sepsis. Pediatric Critical Care Medicine 19(5): 397-405, May 2018.

Weiss SL, Watson RS: Measuring hospital performance in pediatric sepsis: without reliable risk there is no reward. Pediatric Critical Care Medicine 19(5): 489-450, May 2018 Notes: Editorial.

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Last updated: 09/21/2018
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