Department of Anesthesiology and Critical Care

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Francis X. McGowan, Jr., MD, FAAP

Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care Medicine
The Children's Hospital of Philadelphia
34th Street and Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-6515
Fax: 215-590-1924
MD (Medicine)
Duke University School of Medicine, 1983.
Post-Graduate Training
Post Graduate Research Fellow in Cardiology, Duke University, Durham, NC, 1983-1983.
Intern, Pediatrics, Yale-New Haven Hospital, New Haven, CT, 1983-1984.
Resident, Pediatrics, Yale-New Haven Hospital, New Haven, CT, 1984-1986.
Acting Chief Resident, Pediatrics Outpatient Department, Yale-New Haven Hospital, New Haven, CT, 1985-1986.
Resident, Anesthesiology, Yale-New Haven Hospital, New Haven, CT, 1986-1988.
Specialized Year in Pediatric/Pediatric Cardiac Anesthesiology, Yale-New Haven Hospital, New Haven, CT, 1988-1989.
Chief Resident in Anesthesiology, Yale-New Haven Hospital, New Haven, CT, 1988-1989.
Research Fellow, Cardiovascular Pathology, Yale University School of Medicine, Departments of Anesthesiology and Pathology, New Haven, CT, 1988-1989.
American Board of Anesthesiology, 1990.
American Board of Anesthesiology, Subspecialty Certification in Pediatric Anesthesiology, 2013.
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Description of Clinical Expertise

1. Pediatric anesthesiology and perioperative medicine
2. Pediatric cardiac anesthesiology and perioperative medicine
3. Adult congenital cardiac anesthesiology and perioperative medicine

Description of Research Expertise

1. Mechanisms of infant myocardial injury and protection
2. Mitochondrial mechanisms of myocardial injury; cardiac mitochondrial function, damage, and biogenesis
3. Cardiac progenitor cell injury and therapies in congenital heart disease
4. Inflammatory mechanisms in ischemia-reperfusion and cardiopulmonary bypass
5. Intravenous oxygen delivery

Selected Publications

Sun LS, Li G, Miller TLK, Salorio C, Byrne MW, Bellinger DC, Ing CH, Park R, Radcliffe J, Hays SR, DiMaggio CJ, Cooper TJ, Rauh V, Maxwell LG, Youn A, McGowan FX: Neurocognitive outcomes following a single general anesthetic exposure before age 36 months in a sibling-matched cohort: the PANDAS Study. JAMA in press, 2016.

Fiadjoe JE, Nishisaki A, Jagannathan N, Hunyady AI, Greenberg RS, Reynolds PI, Matuszczak ME, Rehman MA, Polaner DM, Szmuk P, Nadkarni VM, McGowan FX, Litman RS, Kovatsis PG: Airway management complications in children with difficult tracheal intubation from the Pediatric Difficult Intubation (Pedi) registry: A prospective cohort analysis. Lancet Respir Med 4: 37-48, 2016 Notes: Epub ahead of Print.

DeWitt ES, Black KJ, Thiagarajan R, DiNArdo JA, Colan SD, Kheir JN, McGowan FX: Effects of commonly used inotropes on myocardial function and oxygen consumption under constant ventricular loading conditions. J Appl Physiol in press, 2016.

He H, Poutias DN, O'Malley T, Kawata M, Kitahori K, McGowan FX: Early induction of mitochondrial oxidative and peroxidative activities promotes infant right ventricular failure. Circ Heart Failure submitted, 2016.

Ward CG, Hines SJ, Maxwell LG, McGowan FX, Sun LS: Neurotoxicity, general anesthesia in young children, and a survey of current pediatric anesthesia practice at US teaching institutions. Pediatric Anesthesia 26(1): 60-65, 2016.

Thomson LM, Seekell RP, McGowan FX, Kheir JN, Polizzotti BD: Freeze-thawing at point-of-use to extend shelf stability of lipid-based oxygen microbubbles for intravenous oxygen delivery. Colloids and Surfaces A: Physiochem Eng Aspects 500: 72-8, 2016.

Levy RJ, Herbstman JB, Bosnjak ZJ, Loepke AW, McGowan FX: Use of Biomarkers to Explore the Neurocognitive Effects of Anesthesia in Children. J Neurosurg Anesth in press, 2016.

Wesley MC, Pereira LM, Scharp LA, Emani SM, McGowan FX Jr, DiNardo JA : Pharmacokinetics of tranexamic acid in neonates, infants, and children undergoing cardiac surgery with cardiopulmonary bypass. Anesthesiology 122(4): 745-758, 2015.

Xiong D,He H, Strauss AW, James J, Tokunaga C, Powers C, Osinska S, Towbin JA, Purevjav J, Balschi JA, McGowan FX: Cardiac-specific VLCAD deficiency induces dilated cardiomyopathy and cold intolerance. Am J Physiol Heart Circ Physiol 306(3): H326-H328, 2014.

Graham EM, Atz AM, McHugh KE, Butts RJ, Baker NL, Stroud RE, Reeves ST, Bradley SM, McGowan FX Jr, Spinale FG: Perioperative steroid treatment does not improve markers of inflammation after cardiac surgery in neonates: Results from a randomized trial. J Thorac Cardiovasc Surg 147(3): 902-908, 2014.

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Last updated: 10/18/2016
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