Department of Anesthesiology and Critical Care

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Francis X. McGowan, Jr., MD, FAAP

Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care Medicine
The Children's Hospital of Philadelphia
34th Street and Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-6515
Fax: 215-590-1924
Education:
MD (Medicine)
Duke University School of Medicine, 1983.
Post-Graduate Training
Post Graduate Research Fellow in Cardiology, Duke University, Durham, NC, 1983-1983.
Intern, Pediatrics, Yale-New Haven Hospital, New Haven, CT, 1983-1984.
Resident, Pediatrics, Yale-New Haven Hospital, New Haven, CT, 1984-1986.
Acting Chief Resident, Pediatrics Outpatient Department, Yale-New Haven Hospital, New Haven, CT, 1985-1986.
Resident, Anesthesiology, Yale-New Haven Hospital, New Haven, CT, 1986-1988.
Chief Resident in Anesthesiology, Yale-New Haven Hospital, New Haven, CT, 1988-1989.
Specialized Year in Pediatric/Pediatric Cardiac Anesthesiology, Yale-New Haven Hospital, New Haven, CT, 1988-1989.
Research Fellow, Cardiovascular Pathology, Yale University School of Medicine, Departments of Anesthesiology and Pathology, New Haven, CT, 1988-1989.
Certifications
American Board of Anesthesiology, 1990.
American Board of Anesthesiology, Subspecialty Certification in Pediatric Anesthesiology, 2013.
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Description of Clinical Expertise

1. Pediatric anesthesiology and perioperative medicine
2. Pediatric cardiac anesthesiology and perioperative medicine
3. Adult congenital cardiac anesthesiology and perioperative medicine

Description of Research Expertise

1. Mechanisms of infant myocardial injury and protection
2. Mitochondrial mechanisms of myocardial injury; cardiac mitochondrial function, damage, and biogenesis
4. Inflammatory mechanisms in ischemia-reperfusion and cardiopulmonary bypass
5. Intravenous oxygen delivery

Selected Publications

He H, Poutias DN, O'Malley T, Kawata M, Kitahori K, McGowan FX: Early induction of mitochondrial oxidative and peroxidative activities promotes infant right ventricular failure. Circ Heart Failure in press, 2017

Kussman BD, Laussen PC, Benni PB, McGowan FX Jr, McElhinney DB: Cerebral Oxygen Saturation in Children with Congenital Heart Disease and Chronic Hypoxemia. Anesth Analg 125(1): 234-240, 2017.

Pouch AM, Aly AH, Lasso A, Nguyen AV, Scanlan AB, McGowan FX, Fichtinger G, Gorman RC, Gorman JH, Yushkevich PA, Jolley MA.: Image segmentation and modeling of the pediatric tricuspid valve in hypoplastic left heart syndrome. Lect Note Comput Sci/FIMH 2017 10263: 95-105, 2017.

Perry DA, Salvin JW, Romfh P, Chen P, Krishnamurthy K, Thomson LM, Polizzotti BD, Vakshoori D, McGowan FX, Kheir JN.: Responsive monitoring of mitochondrial redox states in heart muscle predicts impending cardiac arrest. Sci Transl Med in press, 2017.

Levy RJ, Herbstman JB, Bosnjak ZJ, Loepke AW, McGowan FX: Biomarkers, Genetics, and Epigenetic Studies to Explore the Neurocognitive Effects of Anesthesia in Children. J Neurosurg Anesth Page: 384-388, 2016 Notes: Epub ahead of print.

Sun LS, Li G, Miller TL, Salorio C, Byrne MW, Bellinger DC, Ing C, Park R, Radcliffe J, Hays SR, DiMaggio CJ, Cooper TJ, Rauh V, Maxwell LG, Youn A, McGowan FX: Association Between a Single General Anesthesia Exposure Before Age 36 Months and Neurocognitive Outcomes in Later Childhood. JAMA 315(21): 2312-2320, 2016.

Fiadjoe JE, Nishisaki A, Jagannathan N, Hunyady AI, Greenberg RS, Reynolds PI, Matuszczak ME, Rehman MA, Polaner DM, Szmuk P, Nadkarni VM, McGowan FX, Litman RS, Kovatsis PG: Airway management complications in children with difficult tracheal intubation from the Pediatric Difficult Intubation (Pedi) registry: A prospective cohort analysis. Lancet Respir Med 4: 37-48, 2016 Notes: Epub ahead of Print.

DeWitt ES, Black KJ, Thiagarajan R, DiNArdo JA, Colan SD, Kheir JN, McGowan FX: Effects of commonly used inotropes on myocardial function and oxygen consumption under constant ventricular loading conditions. J Appl Physiol 121: 7-14, 2016.

Ward CG, Hines SJ, Maxwell LG, McGowan FX, Sun LS: Neurotoxicity, general anesthesia in young children, and a survey of current pediatric anesthesia practice at US teaching institutions. Pediatric Anesthesia 26(1): 60-65, 2016.

Thomson LM, Seekell RP, McGowan FX, Kheir JN, Polizzotti BD: Freeze-thawing at point-of-use to extend shelf stability of lipid-based oxygen microbubbles for intravenous oxygen delivery. Colloids and Surfaces A: Physiochem Eng Aspects 500: 72-8, 2016.

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Last updated: 07/25/2017
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