Department of Anesthesiology and Critical Care

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Francis X. McGowan, Jr., MD, FAAP

Professor of Anesthesiology and Critical Care
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care Medicine
The Children's Hospital of Philadelphia
34th Street & Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-590-6515
Fax: 215-590-1415
Education:
BA (Biochemistry)
Brown University, 1979.
MD (Medicine)
Duke University School of Medicine, 1983.
MA (Honorary)
Harvard University, 2002.
Post-Graduate Training
Post Graduate Research Fellow in Cardiology, Duke University, Durham, NC, 1983-1983.
Intern Pediatrics, Yale-New Haven Hospital, New Haven, CT, 1983-1984.
Resident, Pediatrics, Yale-New Haven Hospital, New Haven, CT, 1984-1986.
Acting Chief Resident, Pediatrics Outpatient Department, Yale-New Haven Hospital, New Haven, CT, 1985-1986.
Resident, Anesthesiology, Yale-New Haven Hospital, New Haven, CT, 1986-1988.
Chief Resident in Anesthesiology, Yale-New Haven Hospital, New Haven, CT, 1988-1989.
Specialized Year in Pediatric/Pediatric Cardiac Anesthesiology, Yale-New Haven Hospital, New Haven, CT, 1988-1989.
Research Fellow, Cardiovascular Pathology, Yale University School of Medicine, Departments of Anesthesiology and Pathology, New Haven, CT, 1988-1989.
Certifications
American Board of Anesthesiology, 1990.
American Board of Anesthesiology, Subspecialty Certifcation in Pediatric Anesthesiology, 2013.
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Description of Clinical Expertise

1. Pediatric anesthesiology and perioperative medicine
2. Pediatric cardiac anesthesiology and perioperative medicine
3. Adult congenital cardiac anesthesiology and perioperative medicine

Description of Research Expertise

1. Mechanisms of infant myocardial injury and protection
2. Mitochondrial mechanisms of myocardial injury; cardiac mitochondrial function, damage, and biogenesis
3. Cardiac progenitor cell injury and therapies in congenital heart disease
4. Inflammatory mechanisms in ischemia-reperfusion and cardiopulmonary bypass
5. Intravenous oxygen delivery

Selected Publications

He H, Campbell P, Kawata M, Poutias DN, Friehs I, Hickey J, Gussoni E, McGowan FX: Load-induced mitochondrial reactive oxygen species production promotes electron transport complex dysfunction, mitochondrial damage, and right ventricular failure. Am J Physiol 2014; (in press).

Xiong D,He H, Strauss AW, James J, Tokunaga C, Powers C, Osinska S, Towbin JA, Purevjav J, Balschi JA, McGowan FX: Cardiac-specific VLCAD deficiency induces dilated cardiomyopathy and cold intolerance. Am J Physiol Heart Circ Physiol 306(3): H326-H328, 2014.

He H, Tao H, Xiong H, Duan SZ, McGowan FX, Mortensen RM, Balschi JA: Rosiglitazone causes cardiotoxicity via peroxisome proliferator-activated receptor y-independent mitochondrial oxidative stress in mouse hearts. Toxicol Sci 138(2): 468-481, 2014.

Polizzotti BD, Thomson LM, O'Connell DW, McGowan FX, Kheir JN: Optimization and characterization of stable lipid-based, oxygen-filled microbubbles by mixture design. J Biomed Mater Res B Appl Biomater 2014.

Graham EM, Atz AM, McHugh KE, Butts RJ, Baker NL, Stroud RE, Deardorff RL, Reeves ST, Bradley SM, McGowan FX, Spinale FG: Preoperative steroid treatment does not improve markers of inflammation following cardiac surgery in neonates. J Am Coll Cardiol 147(3): 902-908, 2013.

Friehs I, McGowan FX, Cowan DB, Choi YH, Black KM, Barnett RJ, Bhasin MK, Daly C, Dillon ST, Libermann TA, Del Nidio PJ, Levitsky S, McCully JD: Pressure-overload hypertrophy of the developing heart reveals divergent gene and protein pathways in left and right ventricular myocardium. Am J Physiol Heart Circ Physiol 304: H697-H708, 2013.

Graham EM, Taylor SN, Zyblewski SC, Wolf B, Bradley SM, Hollis BW, McGowan FX, Atz AM: Vitamin D status in neonates undergoing cardiac operations: relationship to cardiopulmonary bypass and association with outcomes. J Pediatr 162(4): 823-826, 2013.

Kheir JK, Thomson L, Polizzotti BD, Wilking JN, Graham DA, Bell DC, O'Connell D, McGowan FX: Bulk manufacture of concentrated oxygen gas-filled microparticles for intravenous oxygen delivery. Adv Healthc Mater 2013;2:1131-41. Adv Healthc Mater (2), 1131-1141, 2013.

Bartholoma MD, He H, Pacak C, Dunning P, Fahey FH, McGowan FX, Cowan DB, Treves ST, Packard A: Biological characterization of F-18-labeled rhodamine B, a potential positron emission tomography perfusion tracer. Nucl Med Biol 40(8): 1043-1048, 2013.

Mehta NM, Costello JM, Bechard LJ, Johnson VM, Zurakowski D, McGowan FX, Laussen PC, Duggan CP: Resting energy expenditure after Fontan surgery in children with single-ventricle heart defects. J Parenter Enteral Nutr 36: 685.692, 2012.

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Last updated: 06/18/2014
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