Penn Dermatology

Penn Dermatology Faculty and Investigators

John T. Seykora, M.D., Ph.D

faculty photo
Associate Professor of Dermatology
Department: Dermatology

Contact information
Department of Dermatology
421 Curie Blvd
Room 1011 BRB II/III
Philadelphia, PA 19104-6142
Office: 2158980170
Fax: 2155732143
Graduate Group Affiliations
Education:
B.A. (Biology with Honors)
University of Chicago, 1986.
M.S. (Biochemistry)
University of Chicago, 1986.
Ph.D. (Cell Biology)
Rockefeller University, 1992.
M.D. (Medicine)
Cornell University Medical College, 1993.
Post-Graduate Training
Intern in Pathology, Hospital at the University of Pennsylvania, 1993-1994.
Resident in Pathology, Hospital of the University of Pennsylvania, 1994-1997.
Fellowship in Dermatopathology, Hospital of the University of Pennsylvania, 1997-1998.
Post-doctoral Fellowship, Department of Dermatology, University of Pennsylvania, 1998-1999.
Certifications
American Board of Pathology- Anatomic Pathology, 1997.
American Boards of Dermatology and Pathology-Dermatopathology, 1998.
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Description of Research Expertise

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Description of Clinical Expertise

Dermatopathology
1. Alopecias-including analysis via horizontal sections
2. Appendageal neoplasms
3. Melanocytic lesions
4. Molecular analysis of biopsy tissue

Selected Publications

Billings, PC, Sanzari, JK, Kennedy, AR, Cengel, KA and Seykora, JT: Quantitation of skin pigmentation using open source image analysis software. Pending revisions Experimental Dermatology 2014.

Wong, WJ, Richardson, T, Seykora, JT, Cotsarelis, G and Simon, MC: Hypoxia inducible factors regulate filaggrin expression and epidermal barrier function. Pending revisions, JID 2014.

Gober MD, Bashir HM, Seykora JT: Reconstructing skin cancers using animal models. Cancer Metastasis Rev. 32: 123-128, 2013

Sanzari, JK, Billings, PC, Diffenderfer, ES, Gridley, DS, Seykora, JT, Kennedy, AR and Cengel, KA: Acute Biological Effects of Solar Particle Radiation on Skin Using a Porcine Model. Radiat Res. Feb 2013.

Kouno M, Lin C, Schechter N, Siegel D, Yang X, Seykora JT, and Stanley, J : Targeted delivery of tumor necrosis factor-related apoptosis-inducing ligand to keratinocytes with a pemphigus monoclonal antibody. J Invest Dermatol 133: 2212-20 2013.

Chehoud, C., Rafail, S., Tyldsley, A., Seykora, J., Lambris, J. and Grice, E. : Complement modulates the cutaneous microbiome and inflammatory milieu. PNAS 110: 15061-6, 2013.

Ratushny, V., Gober, M., Hick, R., Ridky, T., and Seykora, J.: “From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma.” J Clin Invest. 122(2): 464–472, 2012.

Teta, M., Choi, YS, Okegbe, T., Wong, G., Tam, O., Chong, M., Seykora, J., Nagy, A., Littman, D., Andl, T., and Millar, S.: “Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin.” Development 139: 1405-16, 2012.

Wanat KA, Holler PD, Dentchev T, Simbirl K, Robertson E, Seykora JT, Rosenbach M: Viral-Associated Trichodysplasia: characterization of a novel polyoma virus infection with therapeutic insights. Archives of Dermatology 148: 219-23, 2012.

Chu, E Y, Wanat, K A, Miller, C J, Amaravadi, R K, Fecher, L A, Brose, M S, McGettigan, S, Giles, L R, Schuchter, L M, Seykora, J T, Rosenbach, M: Diverse cutaneous side effects associated with BRAF inhibitor therapy: A clinicopathologic study. J Am Acad Dermatol 67: 1265-72 2012.

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Last updated: 10/28/2014
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