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John T. Seykora, M.D., Ph.D

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Associate Professor of Dermatology
Department: Dermatology

Contact information
Department of Dermatology
421 Curie Blvd
Room 1011 BRB II/III
Philadelphia, PA 19104-6142
Office: 2158980170
Fax: 2155732143
Graduate Group Affiliations
B.A. (Biology with Honors)
University of Chicago, 1986.
M.S. (Biochemistry)
University of Chicago, 1986.
Ph.D. (Cell Biology)
Rockefeller University, 1992.
M.D. (Medicine)
Cornell University Medical College, 1993.
Post-Graduate Training
Intern in Pathology, Hospital at the University of Pennsylvania, 1993-1994.
Resident in Pathology, Hospital of the University of Pennsylvania, 1994-1997.
Fellowship in Dermatopathology, Hospital of the University of Pennsylvania, 1997-1998.
Post-doctoral Fellowship, Department of Dermatology, University of Pennsylvania, 1998-1999.
American Board of Pathology- Anatomic Pathology, 1997.
American Boards of Dermatology and Pathology-Dermatopathology, 1998.
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Description of Research Expertise

1. Keratinocyte growth and differentiation-mechanisms of growth control
2. Skin cancer-squamous cell carcinoma
3. Signal transduction-tyrosine kinases and adaptor molecules
4. Murine models of human diseases.
5. Use of organotypic cultures to model disease.
6. Effects of UVB on keratinocytes
7. Psoriasis
8. Dermatopathology-alopecia, appendageal tumors, cancer.

Description of Clinical Expertise

1. Alopecias-including analysis via horizontal sections
2. Appendageal neoplasms
3. Melanocytic lesions
4. Molecular analysis of biopsy tissue

Selected Publications

Ellebrecht, C.T., Bhoj, V.G., Nace, A., Choi, E.J., Mao, X, Cho, M.J.< Di Zenzo, G., Lanzavecchia, A., Seykora, J.T., Cotsarelis, G., Milone, M.C., Payne, A.S.: Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease. Science 353(6295): 179-84, July 2016 Notes: doi: 10.1126/science.aaf6756. Epub 2016 Jun 30.

Gui, J., Gober, M., yang, X, katlinski, K.V., Marshall, C.M., Sharma, M., Werth, V.P., Baker, D.P., Rui, H., Seykora, J.T., Fuchs, S.Y.: Therapeutic elimination of the type I interferon receptor for treating psoriatic sk inflammation. Journal of Investigative Dermatology, 2016 Jun 28 June 2016 Notes: pii: S0022-202X(16)32075-9. doi: 10.1016/j.jid.2016.06.608. (Epub ahead of print.

Oh, J.W., Kloepper, J., Langan, E.A., Kim, Y., Yeo, J., Kim, M.J.< Hsi, T.C., Rose, C., Yoon, G.S., Lee, S.J., Seykora, J.T., Kim, J.C., Sung, Y.K., Kim, M., Paus, R., Plikus, M.V.: A guide to studying human hair follicle cycling in vivo. Journal of Investigative Dermatology 36(1): 134-44, January 2016 Notes: Erratum in: J. Invest. Dermatol. 2016 Apr; 136(4):883.

Taylor, L.A., ODay, C., Dentchev, T., Hood, K., Chu, E.Y., Ridky, T.W., Seykora, J.T.: p15 expression differentiates nevus from melanoma. American Journal of Pathology In Press, 2016.

McNeal, A.S., Liu, K., Nakhate, V., Natale, C.A., Duperret, E.K., Capell, B.C., Dentchev, T., Berger, S.L., Herlyn, M., Seykora, J.T., Ridky, T.W.: CDKN2B loss promotes progression from benign melanocytic nevus to melanoma. Cancer Discov 5(10): 1072-85, October 2015 Notes: doi: 10.1158/2159-8290.CD-15-0196. Epub 2015 Jul 16.

Seykora, J.T., Dentchev, T., Margolis, D.: Fillagrin 2 barrier protein varies inversely with inflammation. Experimental Dermatology May 2015 Notes: May 8 doi:10.1111/exd.12749.

Ortiz, M.L., Kumar V., Martner, A., Mony S., Donthireddy, L., Condamine, T., Seykora, J., Knight, S.C., Malietzis, G., Lee, G.H., Moorghen, M., Lenox, B., Luetteke, N., Celis, E., Gabrilovich, D.: Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells. Journal of Experimental Medicine 2015 Mar 9 212(3): 351-67, March 2015 Notes: doi: 10.1084/jem.20140835. Epub 2015 Feb 9.

Sanzari, J.K., Diffendender, E.S., Hagan, S., Billings, P.C., Gridley, D.S., Seykora, J.T., Kennedy, A.R., Cengel, K.A.: Dermatopathology effects of simulated solar particle event radiation exposure in the porcine model. Life Sciences in Space Research 6: 21-28, 2015.

Gober, M.D., Seykora, J.T.: Characterization of the murine K14-Fyn Y528F transgenic SCC model provides novel therapeutic insights. Medicinal Chemistry 5, 2015 Notes: doi:10:10.4172/2161-0444.1000256.

Johnson, L. Scholler, J. Ohkuri, T., Kosaka, A., Patel, P. McGettigan, S., Nace, A., Dentchev, T., Thekkat, P., Loew, A., Boesteanu, A., Cogdill, A., Chen, T., Fraietta, J., Kloss, C., Posey, A., Engels, B., Singh, R., Ezell, T., Idamakanti, N., Ramones, M., Li, N., Zhou, L., Pleasa, G., Seykora, J., Okada, H., June, C., Brogdon, J., Maus, M.: Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for a Phase I trial in glioblastoma. Science Translational Medicine 7: 275, 2015.

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Last updated: 11/16/2016
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