- Faculty & Staff
Lance B. Becker, MD
Translational Research Laboratories
125 South 31st Street
Philadelphia, PA 19104-3403
BGS (General Studies)
University of Michigan, 1975.
University of Illinois, 1977.
University of Illinois School of Medicine, 1981.
Housestaff, Michael Reese Hospital and Medical Center, Chicago, IL, 1981-1984.
Intern in Internal Medicine, Michael Reese Hospital and Medical Center, Chicago, IL, 1981-1982.
Junior and Senior Assistant Resident in Internal Medicine, Michael Reese Hospital and Medical Center, Chicago, IL, 1982-1984.
Advanced Cardiac Life Support, 1980.
Diplomat, National Board of Medical Examiners, 1982.
Board Certified in Internal Medicine , 1984.
Advanced Trauma Life Support, 1985.
Advanced Cardiac Life Support - Instructor, 1989.
Board Certified in Emergency Medicine , 1990.
Subspecialty Board Certified in Critical Care Medicine , 1991.
Advanced Trauma Life Support, 1991.
National Advanced Cardiac Life Support Faculty, State of Illinois, 1994.
Advanced Trauma Life Support, 1997.
Board Recertification in Emergency Medicine, 2011.
Description of Research ExpertiseLance B. Becker, MD, is a newly recruited Professor of Emergency Medicine at the University of Pennsylvania. Previously Dr. Becker was a Professor at the University of Chicago's Department of Medicine, Section of Emergency Medicine. He was the founder and Director of the Emergency Resuscitation Center at the University of Chicago in Chicago and Argonne National Laboratory, an interdisciplinary team of investigators focused on understanding and treating sudden death from cardiac arrest and from traumatic injuries. He is board certified in internal medicine, emergency medicine and critical care medicine.
Dr. Becker has received numerous national awards and recognition for his work and leadership. He was selected by Emergency Medicine residents as the "Attending Physician of the Year" in 1997, has been awarded the "Time, Feeling, and Focus" award from the American Heart Association, as well as other leadership awards from the National Emergency Cardiac Care Committee of the American Heart Association. Dr. Becker was the National Conference Director for the American Heart Association's Emergency Cardiac Care Evidence Evaluation Conference in September 1999 to create new national CPR recommendations, has served on the National American Heart Association's Basic Life Support Committee and Advanced Life Support subcommittees. He has been a past Chair of the Cardiopulmonary, Perioperative, and Critical Care Council of the American Heart Association and is a past Chairman of the Basic Life Support Committee. He has served as representative to the International Liaison Committee on Resuscitation and helped create and continues to Co-Direct the Resuscitation Science Symposium of the American Heart Association, the leading international venue for the presentation of cutting edge science in resuscitation. At the most recent 2005 International AHA Guidelines Conference for consensus on international resuscitation science and new CPR recommendations, he acted as the Chair for the daily "Controversial Topics" sessions that revisited the most challenging resuscitation topics each day. Dr. Becker has worked closely with the NIH as a reviewer, grantee, and in a leadership role as a the Chair of the Myocardial Protection Working group for the NIH NHLBI's sponsored PULSE Conference and PULSE Leadership Group, which is dedicated to support of research funding in resuscitation research. He also served as a member of the Food and Drug Administration Device Evaluation panels and has appeared before the FDA panels as an expert presenter.
Dr. Becker' research interests are very translational and extend across the basic science laboratory into animal models of resuscitation, and to human therapies. He developed the Emergency Resuscitation Center at the University of Chicago to bring investigators from diverse fields together for multidisciplinary resuscitation research and for improved training of young resuscitation scientists. His cellular studies have helped define cellular reperfusion injury mechanisms, mitochondrial oxidant generation, reactive oxygen and nitrogen species responses to ischemia, apoptotic activation following ischemia, signaling pathways, new cellular cytoprotective strategies, and hypothermia protection. Additional studies are ongoing on development of novel human coolants for rapid induction of hypothermia, inflammatory pathways activated following shock and cardiac arrest, improving the quality of CPR, new defibrillator and cardiopulmonary bypass technologies, epidemiology of sudden death, and novel treatments for cardiac arrest.
Selected PublicationsJoshua W. Lampe, George Bratinov, Theodore Weiland, Josiah D. Garcia, Uday Illindala, Lance B. Becker: High Volume Femoral Vein Infusion Significantly Icreases EtCO2 During Prolonged CPR. Resuscitation Science Symposium, Dallas, TX(329), 141, November 2013.
Youngquist ST, Bartos JA, Matsuura TR, Sarraf M, Houang EM, Segal N, Caldwell EC, Becker LB, Lurie KG, Bates FS, Metzger JM, Yannopoulos D. : Bundled Post-Conditioning Therapy Improves Hemodynamics and Post-Resuscitation Cardiac Function When Administered During the Metabolic Phase of Cardiac Arrest. Resuscitation Science Symposium, Dallas, TX(10), 31, November 2013.
Perman SM, Grossestreuter AV, Gaieski DF, Abella BS, Merchant RM, Becker LB. : Gender Disparities in the Use of Therapeutic Hypothermia After Cardiac Arrest: An Analysis From the Penn Alliance for Therapeutic Hypothermia (PATH) Registry. Resuscitation Science Symposium, Dallas, TX.(335), 144, November 2013.
Sarraf M, Matsuura TR, Bartos JA, Youngquist ST, Houang EM, Segal N, Caldwell EC, Becker LB, Lurie KG, Bates FS, Metzger JM, Yannopoulos D. : Bundle Therapy at the Initiation of CPR with Poloxamer 188, Ischemic Postconditioning and Sevoflurane Leads to Cerebral Recover and Myocardial Protection After 17 minutes of Untreated Cardiac Arrest. Resuscitation Science Symposium, Dallas, TX.(110), 56, November 2013.
Joshua Lampe, George Bratinov, Theodore Weiland, Josiah D. Garcia, Lance B. Becker: Temperature Distribution During Hypothermia Induction Depends on Cooling Method and Blood Flow. Resusciation Science Symposium, Dallas, TX(326), 140, November 2013.
Joshua W. Lampe, Tai Yin, George Bratinov, Josiah Garcia, Theodore Weiland, Christopher L. Kaufman, Lance B. Becker: Importance of Release Velocity for Improved Hemodynamic Power at Varying Chest Compression Depths. Resuscitation Science Symposium, Dallas, TX(144), 69, November 2013.
Joshua W. Lampe, Tai Yin, Josiah D. Garcia, George Bratinov, Theodore Weiland, Christopher L. Kaufman, Lance B. Becker: Relationship Between End Tidal CO2 and Hemodynamic Flow in a Swine Model of Prolonged Cardiac Arrest. Resuscitation Science Symposium, Dallas, TX(142), 68, November 2013.
Joshua W. Lampe, Mary A. Selak, Tong Da, Wei Zhang, Ming Yin, Chih-Hsien Wang, Meagan J. McManus, Douglas C. Wallace, Lance B. Becker: Impaired Mitochondrial Function Following The Metabolic Phase of Cardiac Arrest and Resuscitation: Differences in Tissue Vulnerability, Site and Severity Dysfunction. Resuscitation Science Symposium, Dallas, TX(327), 141, November 2013.
Joshua W. Lampe, Tai Yin, George Bratinov, Josiah D. Garcia, Theodore Weiland, Christopher L. Kaufman, lance B. Becker: Impact of Chest Compression Quality and Positive Pressure Ventilation on Central Venous and Arterial Hemodynamics During Cardiac Arrest. Resuscitation Science Symposium, Dallas, TX(143), 69, November 2013.
Joshua W. Lampe, Tong Da, Mary A. Selak, Meagan J. McManus, Douglas C. Wallace, Lance B. Becker: Critical Role for intramitochondrial NADPH Generation for Survival after Cardiac Arrest: Studies in the Nicotinamide Nucleotide Transhydrogenase Deficit Mouse. Resuscitation Science Symposium, Dallas, TX(328), 141, November 2013.