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Peter B. Crino, MD, PhD
Associate Professor of Neurology
Department: Neurology
Contact information
Clinical: Department of Neurology 3 West Gates Bldg. 3400 Spruce St.
Lab: 247 Clinical Research Building
Philadelphia, PA 19104
Lab: 247 Clinical Research Building
Philadelphia, PA 19104
Office: 215-349-5312
Fax: 215-573-2029
Fax: 215-573-2029
Email:
peter.crino@uphs.upenn.edu
peter.crino@uphs.upenn.edu
Graduate Group Affiliations
Publications
Education:
B.A.
Binghamton University , 1984.
M.D.
Yale University School of Medicine, 1990.
Ph.D.
Boston University School of Medicine Department of Behavioral Neuroscience , 1990.
B.A.
Binghamton University , 1984.
M.D.
Yale University School of Medicine, 1990.
Ph.D.
Boston University School of Medicine Department of Behavioral Neuroscience , 1990.
Post-Graduate Training
Internship, Internal Medicine, Yale-New Haven Hospital Yale University School of Medicine, 1990-1991.
Neurology Residency, University of Pennsylvania Medical Center, 1991-1994.
Clinical Fellow, PENN Epilepsy Center, Department of Neurology University of Pennsylvania Medical Center, 1994-1997.
Howard Hughes Medical Institute Post-Doctoral Fellow, Department of Pharmacology University of Pennsylvania School of Medicine, 1994-1997.
Internship, Internal Medicine, Yale-New Haven Hospital Yale University School of Medicine, 1990-1991.
Neurology Residency, University of Pennsylvania Medical Center, 1991-1994.
Clinical Fellow, PENN Epilepsy Center, Department of Neurology University of Pennsylvania Medical Center, 1994-1997.
Howard Hughes Medical Institute Post-Doctoral Fellow, Department of Pharmacology University of Pennsylvania School of Medicine, 1994-1997.
Certifications
National Board of Medical Examiners, 1991.
Diplomat of the American Board of Psychiatry and Neurology, 1996.
Permanent linkNational Board of Medical Examiners, 1991.
Diplomat of the American Board of Psychiatry and Neurology, 1996.
Description of Research Expertise
KEY WORDS:Development, cortical dysplasias, epilepsy, brain tumors, tuberous sclerosis, hemimegalencephaly
RESEARCH INTERESTS
Cortical maldevelopment as it relates to epilepsy, mental retardation, and autism; The Tuberous Sclerosis Complex; Brain tumors
RESEARCH TECHNIQUES
Molecular biology; mRNA amplification from single human neurons, immunohistochemistry, cortical slice cultures
RESEARCH SUMMARY
My laboratory is interested in understanding how aberrant development of the cerebral cortex contributes to pervasive neurological disorders such as epilepsy, mental retardation, and autism. Specifically, we are studying the molecular pathogenesis of cortical dyslamination in a variety of syndromes associated with these disorders including focal cortical dysplasia, heterotopias, tuberous sclerosis, and hemimegalencephaly. Our lab approach includes amplification of mRNA from single immunohistochemically labeled neurons in human brain specimens. We are able to determine the differential expression of numerous genes in a subset of phenotypically defined cells.
By quantifying the relative abundances of developmentally relevant genes, we hope to identify cellular pathways which, when disrupted, lead to abmormal layer formaton in the cerebral cortex. Finally, we study the cellular mechanisms that modulate proliferation of brain neoplasms such as primitive neuroectodermal tumors, gliomas, and subependymal giant cell astrocytomas in tuberous sclerosis.
Description of Clinical Expertise
Epilepsy, EEG, tuberous sclerosis, brain malformations, autismDescription of Other Expertise
Molecular biology, gene expression analysis, immunohistochemistrySelected Publications
Baybis M, Lynch D, Lee A, Patel, A, McKhann II. G, Chugani D, Kupsky WJ, Aronica E, Crino PB.: Altered Expression of Neurotransmitter Receptor Subunit and Uptake Site mRNAs in Hemimegalencephaly Epilepsia 2005.Baybis M, Yu J, Lee A, Golden JA, Weiner H, McKhann II G, Aronica, E, Crino PB. : Activation of the mTOR cascade distinguishes cortical tubers from focal cortical dysplasia. Annals of Neurology 2004.
Crino PB. : The molecular pathogenesis of focal cortical dysplasia and hemimegalencephaly. J Child Neurology, 2005.
Crino PB: The molecular pathogenesis of tuber formation in the Tuberous Sclerosis Complex. J Child Neurol 2005.
Kolson DK, Sabnekar P, Baybis M, Crino PB. : Gene expression in TUNEL-positive neurons in HIV infected brain. J Neurovirol 10(1): 102-107, 2004.
Najm I, Ying Z, Babb T, Crino PB, MacDonald, R, Mathern G, Spreafico R. : Mechanisms of epileptogenesis in cortical dysplasia. Neurology 62(6): 9-13, 2004.
Ess KC, Uhlmann EJ, Li W, Li H, Declue JE, Crino PB, Gutmann DH.: Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to characterize human TSC brain pathology. Glia 46(1): 28-40, 2004.
Telfeian AE, Tseng HC, Baybis M, Crino PB, Dichter MA. : Differential expression of GABA and Glutamate-receptor subunits and enzymes involved in GABA metabolism between electrophysiologically identified hippocampal CA1 pyramidal cells and interneurons. Epilepsia 44: 143-149, 2003.
Hua Y, Crino PB. : Lineage analysis of human focal cortical dysplasia. Cerebral Cortex 13: 693-699, 2003.
Lee A, Maldonado M, Baybis MS, Walsh CA, Scheithauer B, Yeung R, Parent J, Weiner HL, and Crino PB. : Markers of cellular proliferation are expressed in cortical tubers. Annals of Neurology 668-673, 2003.
