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Brenda Elaine Porter, MD, PhD
Assistant Professor of Neurology
Department: Neurology
Contact information
502C Abramson Research Building
The Children's Hospital of Philadelphia
34th and Civic Center Blvd
Philadelphia, PA 19104
The Children's Hospital of Philadelphia
34th and Civic Center Blvd
Philadelphia, PA 19104
Office: 267 426-5210
Fax: 215 590-3779
Fax: 215 590-3779
Email:
porterb@mail.med.upenn.edu
porterb@mail.med.upenn.edu
Graduate Group Affiliations
Education:
A.B. (Biochemistry)
Washington University , 1987.
M.D.
Washington University, 1995.
Ph.D. (Neuroscience)
Washington University , 1995.
A.B. (Biochemistry)
Washington University , 1987.
M.D.
Washington University, 1995.
Ph.D. (Neuroscience)
Washington University , 1995.
Post-Graduate Training
Intern in Pediatrics, St. Louis Children’s Hospital, St. Louis, 1995-1996.
Resident in Pediatrics, St. Louis Children’s Hospital, St. Louis, 1996-1997.
Resident in Child Neurology, The Children’s Hospital of Philadelphia, Philadelphia, 1997-2000.
Fellowship, Pediatric Epilepsy, The Children’s Hospital of Philadelphia, Philadelphia, 2000-2002.
Postdoctoral Fellow, The Children’s Hospital of Philadelphia, mentor Dr. Amy Brooks-Kayal, 2002-2003.
Intern in Pediatrics, St. Louis Children’s Hospital, St. Louis, 1995-1996.
Resident in Pediatrics, St. Louis Children’s Hospital, St. Louis, 1996-1997.
Resident in Child Neurology, The Children’s Hospital of Philadelphia, Philadelphia, 1997-2000.
Fellowship, Pediatric Epilepsy, The Children’s Hospital of Philadelphia, Philadelphia, 2000-2002.
Postdoctoral Fellow, The Children’s Hospital of Philadelphia, mentor Dr. Amy Brooks-Kayal, 2002-2003.
Certifications
American Board of Psychiatry and Neurology with Special Qualification in Child Neurology , 2002.
Pediatrics, 2002.
American Board of Psychiatry and Neurology, Clinical Electrophysiology , 2003.
Permanent linkAmerican Board of Psychiatry and Neurology with Special Qualification in Child Neurology , 2002.
Pediatrics, 2002.
American Board of Psychiatry and Neurology, Clinical Electrophysiology , 2003.
Description of Research Expertise
My lab is interested in understanding changes in the brain that cause epilepsy. We have focused on changes in transcription and translation that contribute to the development of epilepsy. We hope to identify gene targets that we can manipulate to prevent the development of epilepsy or revert an epileptic brain back to a pre-epileptic state.Description of Clinical Expertise
I am a pediatric neurologist specializing in epilepsy. I treat pediatric epilepsy patients with medications, diet and surgery trying to eliminate their seizures. I have a clinic for children with tuberous sclerosis treating seizures, and the learning and behavioral problems associated with tuberous sclerosis.Selected Publications
Peltzer, B., Alonso, W. D., Porter, B. E.: Topiramate and Adrenocorticotropic Hormone (ACTH) as Initial Treatment for Infantile Spasms. J Child Neurol 2009.Porter, B. E., Lund, I. V., Varodayan, F. P., Wallace, R. W., Blendy, J. A.: The role of transcription factors cyclic-AMP responsive element modulator (CREM) and inducible cyclic-AMP early repressor (ICER) in epileptogenesis. Neuroscience 152(3): 829-36, 2008.
Brown, M. W., 3rd, Porter, B. E., Dlugos, D. J., Keating, J., Gardner, A. B., Storm, P. B., Jr., Marsh, E. D.: Comparison of novel computer detectors and human performance for spike detection in intracranial EEG. Clin Neurophysiol 118(8): 1744-52, 2007.
Judkins, A. R.,* Porter, B. E.,* Cook, N., Clancy, R. R., Duhaime, A. C., Golden, J. A. * equal first authors: Dystrophic neuritic processes in epileptic cortex. Epilepsy Res 70(1): 49-58, 2006.
Porter, B. E., Cui, X. N., Brooks-Kayal, A. R.: Status epilepticus differentially alters AMPA and kainate receptor subunit expression in mature and immature dentate granule neurons. Eur J Neurosci 23(11): 2857-63, 2006.
Raol, Y. H., Zhang, G., Lund, I. V., Porter, B. E., Maronski, M. A., Brooks-Kayal, A. R.: Increased GABA(A)-receptor alpha1-subunit expression in hippocampal dentate gyrus after early-life status epilepticus. Epilepsia 47(10): 1665-73, 2006.
Porter, B. E., Zhang, G., Celix, J., Hsu, F. C., Raol, Y. H., Telfeian, A., Gallagher, P. R., Coulter, D. A., Brooks-Kayal, A. R.: Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients. Neurobiology of Disease 18(3): 484-91, 2005.
