Katalin Kariko, PhD
Adjunct Associate Professor of Neurosurgery
Senior Research Investigator, Department of Neurosurgery
Department: Neurosurgery
Contact information
371b Stemmler Hall
Philadelphia, PA 19104
Philadelphia, PA 19104
Office: 215-662-7927
Fax: 215-349-8157
Fax: 215-349-8157
Email:
kariko@mail.med.upenn.edu
kariko@mail.med.upenn.edu
Publications
Education:
BS (Biology)
József Attila University, Szeged, Hungary, 1978.
PHD (Biochemistry)
József Attila University, Szeged, Hungary, 1982.
BS (Biology)
József Attila University, Szeged, Hungary, 1978.
PHD (Biochemistry)
József Attila University, Szeged, Hungary, 1982.
Post-Graduate Training
Postdoctoral Fellow, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary, 1982-1985.
Postdoctoral Fellow, Department of Biochemistry, Temple University, Philadelphia, PA, 1985-1988.
Postdoctoral Fellow, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, 1988-1989.
Permanent linkPostdoctoral Fellow, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary, 1982-1985.
Postdoctoral Fellow, Department of Biochemistry, Temple University, Philadelphia, PA, 1985-1988.
Postdoctoral Fellow, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, 1988-1989.
Description of Research Expertise
Messenger RNA-based gene therapy.RNA-induced immune reactions.
Molecular bases of ischemic tolerance.
Treatment of brain ischemia
Selected Publications
Anderson B, Muramatsu H, Nallagatla SR, Bevilacqua P, Sansing L, Weissman D, Karikó K: Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acids Res 38: 5884-92, 2010.Karikó, K., Muramatsu, H., Welsh, FA., Ludwig, J., Kato, H., Akira, S., Weissman, D.: Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Molecular Therapy 16: 1833-1840, 2008.
Karikó K, Buckstein M, Ni H, Weissman D.: Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA. Immunity 23(2): 165-75, 2005.
Karikó K, Weissman D, Welsh FA: Inhibition of toll-like receptor and cytokine signaling--a unifying theme in ischemic tolerance. J Cereb Blood Flow Metab 24(11): 1288-304, 2004.
Karikó K, Ni H, Capodici J, Lamphier M, Weissman D.: mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 279(13): 12542-12550, 2004.
