Department of Neurosurgery

Penn Neurosurgery
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faculty photo

M. Sean Grady, MD

Charles Harrison Frazier Professor of Neurosurgery
Attending Neurosurgeon
CPUP Board of Directors
Neurosurgeon in Chief
Residency Program Director
University of Pennsylvania Chair and Directors Committee
CPUP Executive Committee
Chairman of HUP Medical Board
Department: Neurosurgery

Contact information
HUP - 3 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-349-8325
Fax: 215-349-5108
Education
B.A. (Biology)
University of California, San Diego, 1977.
M.D.
Georgetown University School of Medicine, 1981.
Post-Graduate Training
Intern, Department of Surgery, University of Virginia, Charlottesville, 1981-1982.
Resident , Neurological Surgery, University of Virginia, 1982-1987.
Certifications
American Board of Neurological Surgery, 1990.
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Description of Research Expertise

Research interests include memory dysfunction resulting from traumatic brain injury and minimally invasive neurosurgery.

Description of Clinical Expertise

Dr. Grady was appointed the Charles Harrison Frazier Professor & Chairman of the Department of Neurosurgery at the University of Pennsylvania School of Medicine in March 1999. He received his undergraduate degree from the University of California San Diego and medical degree from Georgetown University School of Medicine. He trained in Neurological Surgery at the University of Virginia from 1981 - 1987 and was a faculty member at the University of Washington from 1987 - 1999. He is Board Certified by the American Board of Neurological Surgeons and is a fellow of the American College of Surgeons. Dr. Grady serves as the Secretary for American Board of Neurological Surgery from 2004 to present and is a member of the editorial board for the Journal of Neurosurgery.

His clinical focus is in the area of Cranial Base Tumors, Pituitary Tumors, Meningiomas, Schwannomas, Malignant Skull Base Tumors as well as Cerebrovascular Disorders, Aneurysms, AVM's. Dr. Grady and Dr Bert O’Malley (Chairman, Department of Otorhinolaryngology, Head and Neck Surgery) are co-directors of the Cranial Base Center. In addition, he performs general neurosurgery procedures for herniated discs of the back and neck.

Description of Other Expertise

Philadelphia Magazine Top Doctors 2004, 2005, 2006, 2007.

Selected Publications

Chawla S, Wang S, Wolf RL, Woo JH, Wang J, O'rourke DM, Judy KD, Grady MS, Melhem ER, Poptani H: Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas. AJNR- Am J Neuroradiol September 2007.

Chen HI, Heuer GG, Zaghloul K, Simon SL, Weigele JB, Grady MS: Lumbar vertebral hemangioma presenting with the acute onset of neurological symptoms. Case report. J Neurosurg Spine 1: 80-5, July 2007.

Cohen AS, Pfister BJ, Schwarzbach E, Grady MS, Goforth PB, Satin LS: Injury-induced alterations in CNS electrophysiology. Prog Brain Res 161: 143-69, 2007.

Grady, MS: Surgical Education in the twenty-first century. J Neurosurg 106(6): 959-60, June 2007.

Watridge CB, Solomon RA, Grady MS, Popp AJ, Quest DO, Kondziolka D, Giannotta SL: Access to emergency care. Bull Am Coll Surg 92(4): 44-5, April 2007.

Grady MS, Lifshitz J, Witgen B: Acute cognitive impairment after lateral fluid percussion brain injury recovers by 1 month: Evaluation by conditional fear response. Behavioural Brain Research 177(2): 347-357, February 2007.

Cohen A, Grady MS, Lifshitz J, Schwarzbach E, Tran L, Witgen B: Response of the Contralateral Hippocampus to Lateral Fluid Percussion Brain Injury. Journal of Neurotrauma 9(23): 1330-1342, Nov 2006.

Witgen B, Lifshitz J, Grady MS: Inbred mouse strains as a tool to analyze hippocampal neuronal loss after brain injury: a stereological study. Journal of Neurotrauma 9: 1320-9, September 2006.

Schlosser RJ, Woodworth BA, Wilensky EM, Grady MS, Bolger WE: Spontaneous cerebrospinal fluid leaks: a variant of benign intracranial hypertension. Ann Otol Rhinol Laryngol 15(7): 495-500, July 2006.

Witgen BM, Grady MS, Nyengaard JR, Gundersen HJ: A new fractionator principle with varying sampling fractions: exemplified by estimation of synapse number using electron microscopy. Journal of Microscopy 222(Pt 3): 251-255, Jun 2006.

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Last updated: 10/11/2007
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