M. Sean Grady, M.D.
Charles Harrison Frazier Professor of Neurosurgery
Attending Neurosurgeon, The Children's Hospital of Philadelphia
CPUP Board of Directors, Hospital of the University of Pennsylvania
Chairman Department of Neurosurgery/Neurosurgeon in Chief, Hospital of the University of Pennsylvania
Neurosurgeon in Chief - Hospital of the University of Pennsylvania , University of Pennsylvania
University of Pennsylvania Chair and Directors Committee, Hospital of the University of Pennsylvania
CPUP Executive Committee, UPHS
Department: Neurosurgery
Contact information
HUP - 3 Silverstein
3400 Spruce Street
clinical: 215.662.3483
administrative: 215.349.8325
Philadelphia, PA 19104
3400 Spruce Street
clinical: 215.662.3483
administrative: 215.349.8325
Philadelphia, PA 19104
Email:
gradys@uphs.upenn.edu
gradys@uphs.upenn.edu
Education:
B.A. (Biology)
University of California, San Diego, 1977.
M.D.
Georgetown University School of Medicine, 1981.
B.A. (Biology)
University of California, San Diego, 1977.
M.D.
Georgetown University School of Medicine, 1981.
Post-Graduate Training
Intern, Department of Surgery, University of Virginia, Charlottesville, 1981-1982.
Resident , Neurological Surgery, University of Virginia, 1982-1987.
Intern, Department of Surgery, University of Virginia, Charlottesville, 1981-1982.
Resident , Neurological Surgery, University of Virginia, 1982-1987.
Certifications
American Board of Neurological Surgery, 1990.
Permanent linkAmerican Board of Neurological Surgery, 1990.
Description of Research Expertise
Dr. Grady's research interests include memory dysfunction resulting from traumatic brain injury and minimally invasive neurosurgery.Description of Clinical Expertise
Dr. Grady was appointed the Charles Harrison Frazier Professor & Chairman of the Department of Neurosurgery at the Perelman School of Medicine, University of Pennsylvania in March 1999. He received his undergraduate degree from the University of California, San Diego and medical degree from Georgetown University School of Medicine. He trained in Neurological Surgery at the University of Virginia from 1981-1987 and was a faculty member at the University of Washington from 1987-1999. He is Board Certified by the American Board of Neurological Surgeons and is a fellow of the American College of Surgeons. Dr. Grady served as the Secretary for American Board of Neurological Surgery from 2004-2008, and was appointed Chairman of the ABNS from 2008-2009. Dr. Grady served as a member of the editorial board for the Journal of Neurosurgery from 2000-2010.Dr. Grady's clinical focus is in the area of Cranial Base Tumors, Pituitary Tumors, Meningiomas, Schwannomas, Malignant Skull Base Tumors as well as Cerebrovascular Disorders, Aneurysms, AVM's. Dr. Grady and Dr. Bert O’Malley (Chairman, Department of Otorhinolaryngology - Head and Neck Surgery) are co-directors of the Cranial Base Center. In addition, Dr. Grady performs general neurosurgery procedures for herniated discs of the back and neck.
Description of Other Expertise
Philadelphia Magazine Top Doctors 2004-2011.Selected Publications
Grady MS, Lee J, O'Malley B, Palmer J, Ramakrishnan V: Sphenoid Sinus Anatomy and Suprasellar Extension of Pituitary Tumors. Journal of Neurosurgery 2013.Xiong G, Zhang L, Mojsilovic-Petrovic J, Arroyo E, Elkind J, Kundu S, Johnson B, Smith CJ, Cohen NA, Grady SM, Cohen AS: GABA and glutamate are not colocalized in mossy fiber terminals of developing rodent hippocampus. Brain Res 20(1474): 40-9, Sep 2012.
Selden N, Origitano T, Burchiel K, Getch C, Anderson V, McCartney S, Abdulrauf S, Barrow D, Ehni B, Grady MS, Hadjipanayis C, Heilman C, Popp AJ, Sawaya R, Schuster J, Wu J, Barbaro N: A National Fundamentals Curriculum for Neurosurgery PGYI Residents: The 2010 Society of Neurological Surgeons Boot Camp Courses. Neurosurgery 70(4): 971-981 April 2012.
Pisapia J, Xu X, Kelly J, Yeung J, Carrion G, Tong H, Meghan S, El-Falaky OM, Grady MS, Smith DH, Zaitsev S, Muzykantov VR, Stiefel MF, Stein SC: Microthrombosis after experimental subarachnoid hemorrhage: Time course and effect of red blood cell-bound thrombin-activated pro-urokinase and clazosentan; Experimental Neurology 233(1): 357–363 Jan 2012.
Wolk DA, Grachev ID, Buckley C, Kazi H, Grady MS, Trojanowski JQ, Hamilton RH, Sherwin P, McLain R, Arnold SE: Association Between In Vivo Fluorine 18-Labeled Flutemetamol Amyloid Positron Emission Tomography Imaging and In Vivo Cerebral Cortical Histopathology. Arch Neurol 68(11): 1398-1403, November 2011.
Wade AN, Baccon J, Grady MS, Judy KD, O'Rourke DM, Snyder PJ : Clinically silent somatotroph adenomas are common. Eur J Endocrinol 165(1): 39-44, July 2011 Notes: Epub April 2011.
Hamilton R, Patel S, Lee E, Jackson E, Lopinto J, Arnold S, Clark C, Basil A, Shaw LM, Xie SX, Grady MS, Trojanowski JQ : Lack of Shunt Response in Suspected Idiopathic NPH with AD Pathology. Annals of Neurology 68(4): 535-40, October 2010.
Weiner GM, Lacey MR, Mackenzie L, Shah DP, Frangos SG, Grady MS, Kofke A, Levine J, Schuster J, Le Roux PD: Decompressive craniectomy for elevated intracranial pressure and its effect on the cumulative ischemic burden and therapeutic intensity levels after severe traumatic brain injury. Neurosurgery 66(6): 1111-8, June 2010.
Lee JY, Lega B, Bhowmick D, Newman JG, O'Malley BW Jr, Weinstein GS, Grady MS, Welch WC: Da Vinci Robot-assisted transoral odontoidectomy for basilar invagination. ORL J Otorhinolaryngol Relat Spec 72(2): 91-5, May 2010.
Kim MN, Durduran T, Frangos S, Edlow BL, Buckley EM, Moss HE, Zhou C, Yu G, Choe R, Maloney-Wilensky E, Wolf RL, Grady MS, Greenberg JH, Levine JM, Yodh AG, Detre JA, Kofke WA: : Noninvasive measurement of cerebral blood flow and blood oxygenation using near-infrared and diffuse correlation spectroscopies in critically brain-injured adults: Neurocrit Care 12(2): 173-80, April 2010.
