Neurosurgery

Faculty

faculty photo

Steven Brem, M.D.

Professor of Neurosurgery at the Hospital of the University of Pennsylvania
Department: Neurosurgery

Contact information
3400 Spruce Street, 3rd Floor Silverstein
Department of Neurosurgery
Philadelphia, PA 19104
Office: (215) 662-7854
Education:
BA (Magna Cum Laude)
Rutgers University, 1968.
MD (Medicine - Cum Laude)
Harvard Medical School, 1972.
Post-Graduate Training
Surgery , Massachusetts General Hospital - Intership , 1972-1973.
Neurosurgery, Massachusetts General Hospital - Residency , 1973-1981.
Clinical Associate, Oncology, Laboratory of Pathophysiology, National Cancer Institute - Postdoctoral Research, 1974-1976.
Neurosurgery, New York Hospital, Cornell Medical Center - Fellowship , 1979-1980.
Certifications
National Board of Medical Examiners, 1973.
Royal College of Physicians and Surgeons of Canada, Neurosurgery Fellowship , 1982.
Province of Quebec, Neurosurgery , 1982.
American Board of Neurological Surgery, 1983.
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Description of Clinical Expertise

Complex Brain Tumor Surgery; Surgery of Intrinsic and Metastatic Brain Tumors; Pituitary Tumors; Acoustic Neuromas; Meningiomas; Skull Base Surgery; Brain Mapping; Health Outcomes; Evidence-Based Medicine;

Description of Research Expertise

Angiogenesis, Neuro-Oncology, Translational Drug Discovery, Personalized Medicine, Genomics, Biomarkers, Experimental Therapeutics, Brain Mapping, Health Outcomes, Brain Metastases, Clinical Guidelines, Clinical Pathways, Glioma Invasion, Targeted Brain Tumor Therapies

Selected Publications

Coppola Domenico, Balducci Lodovico, Chen Dung-Tsa, Loboda Andrey, Nebozhyn Michael, Staller Aileen, Fulp William J, Dalton William, Yeatman Timothy, Brem Steven: Senescence-Associated-Gene signature identifies genes linked to age, prognosis, and progression of human gliomas. Journal of geriatric oncology Sep 2014.

Rosenfeld Myrna R, Ye Xiaobu, Supko Jeffrey G, Desideri Serena, Grossman Stuart A, Brem Steven, Mikkelson Tom, Wang Daniel, Chang Yunyoung C, Hu Janice, McAfee Quentin, Fisher Joy, Troxel Andrea B, Piao Shengfu, Heitjan Daniel F, Tan Kay-See, Pontiggia Laura, O'Dwyer Peter J, Davis Lisa E, Amaravadi Ravi K: A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme. Autophagy 10(8): 1359-68, Aug 2014.

Brem Steven, Meyers Christina A, Palmer Gary, Booth-Jones Margaret, Jain Surbhi, Ewend Matthew G: Preservation of neurocognitive function and local control of 1 to 3 brain metastases treated with surgery and carmustine wafers. Cancer 119(21): 3830-8, Nov 2013.

Chacko Ann-Marie, Li Chunsheng, Pryma Daniel A, Brem Steven, Coukos George, Muzykantov Vladimir: Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood-brain barrier divide. Expert opinion on drug delivery 10(7): 907-26, Jul 2013.

Abdullah Kalil G, Lubelski Daniel, Nucifora Paolo G P, Brem Steven: Use of diffusion tensor imaging in glioma resection. Neurosurgical focus 34(4): E1, Apr 2013.

Nabors L Burt, Mikkelsen Thomas, Hegi Monika E, Ye Xiaubu, Batchelor Tracy, Lesser Glenn, Peereboom David, Rosenfeld Myrna R, Olsen Jeff, Brem Steve, Fisher Joy D, Grossman Stuart A: A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306). Cancer 118(22): 5601-7, Nov 2012.

Xiao Yuanyuan, Decker Paul A, Rice Terri, McCoy Lucie S, Smirnov Ivan, Patoka Joseph S, Hansen Helen M, Wiemels Joe L, Tihan Tarik, Prados Michael D, Chang Susan M, Berger Mitchel S, Kosel Matthew L, Fridley Brooke L, Lachance Daniel H, O'Neill Brian Patrick, Buckner Jan C, Thompson Reid C, Nabors Louis Burt, Olson Jeffrey J, Brem Steve, Madden Melissa H, Browning James E, Wiencke John K, Egan Kathleen M, Jenkins Robert B, Wrensch Margaret R: SSBP2 variants are associated with survival in glioblastoma patients. Clinical cancer research : an official journal of the American Association for Cancer Research 18(11): 3154-62, Jun 2012.

Seaman Brian, Brem Steven, Fromm Allison, Staller Aileen, McCardle Timothy, Jain Surbhi: Intracranial spread of Merkel cell carcinoma to the cerebellopontine angle. Journal of cutaneous medicine and surgery 16(1): 54-60, Jan-Feb 2012.

Chinnaiyan Prakash, Chowdhary Sajeel, Potthast Lisa, Prabhu Antony, Tsai Ya-Yu, Sarcar Bhaswati, Kahali Soumen, Brem Steven, Yu H Michael, Rojiani Amyn, Murtagh Ryan, Pan Edward: Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma. Neuro-oncology 14(1): 93-100, Jan 2012.

Moody Patricia, Murtagh Kevin, Piduru Sarat, Brem Steven, Murtagh Reed, Rojiani Amyn M: Tumor-to-tumor metastasis: pathology and neuroimaging considerations. International journal of clinical and experimental pathology 5(4): 367-73, 2012.

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Last updated: 09/30/2014
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