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Timothy H Lucas Jr., M.D., Ph.D.

Assistant Professor of Neurosurgery
Director, Translational Neuromodulation Laboratory, Department of Neurosurgery, University of Pennsylvania
Associate Director, Center for Neuroengineering & Therapeutics, University of Pennsylvania
Director, Neurosurgery Gene Therapy Program, University of Pennsylvania
Director, Laser Neurosurgery Center, University of Pennsylvania
Mack Technology Fellow, Wharton Business School, University of Pennsylvania
Department: Neurosurgery

Contact information
3400 Spruce Street
3rd Floor Silverstein
Philadelphia, PA 19104
Office: 215-615-0578
Fax: 215-349-5534
Lab: 215-746-1336
Graduate Group Affiliations
Education:
B.S. (Neurobiological Sciences & Psychobiology)
University of Florida, 1996.
M.D. (Medicine)
University of Florida, 2001.
Ph.D. (Physiology & Biophysics)
University of Washington, 2009.
MCHI (Health Care Innovation, Public Health and Health Policy)
University of Pennsylvania, 2019.
Post-Graduate Training
Intern in General Surgery, University of Washington, 2001-2002.
Resident in Neurological Surgery, University of Washington, 2002-2009.
Specialist Registrar in Neurological Surgery, St. George's National Healthcare Trust, London, England, UK, 2006-2007.
Chief Resident in Neurological Surgery, University of Washington, 2009-2010.
Fellow in Neurosurgical Oncology & Cerebrovascular Neurosurgery, University of Washington, 2010-2010.
Clinical Experience in Stereotactic & Functional Neurosurgery, University of California San Francisco, 2011-2011.
Fellow in Neurosurgical Oncology Brain Mapping, University of California San Francisco, 2011-2011.
Certifications
American Board of Neurological Surgeons (Board Eligible), 2011.
American Board of Neurological Surgery, 2016.
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Description of Clinical Expertise

Epilepsy Surgery
Temporal Lobectomy
Minimally invasive neurosurgery
Laser Neurosurgery
Neuromodulation
Endoscopic Surgery
Sports Neurosurgery
Cortisectomy / Topectomy
Corpus Callostomy / Functional Disconnection Surgery
Trigeminal neuralgia
Microvascular decompression
Stereotactic and Functional Neurosurgery
Movement Disorder Surgery (Parkinson's Disease, Essential Tremor, Dystonia)
Glioma Surgery (Low Grade, High Grade, Adult, Pediatric)
Insular Lesions
Brain Mapping (Speech, Motor, Sensory; cortical and subcortical)
Extraoperative Brain Mapping
Neuroprosthetics
Brain-machine interface / Brain-computer interface
Spine Disorders
Spinal Fusion
Skull base surgery
Brain Plasticity
Eloquent Cortex Lesions (motor, sensory, speech, visual cortex)
Traumatic brain and spine injury

Description of Research Expertise

Brain-machine interface / Brain-computer interface
Motor Cortex Functional Organization
Voluntary Movement
Speech and Language Organization
Cortical Plasticity
Basal Ganglia - Cortical Interactions
Cortical/Basal Ganglia Stimulation
Cortical Spike and Local Field Recording
Basal Ganglia Spike and Local Field Recording
Neuroprosthetics
Spinal Cord Stimulation and Mapping
Electromyography

Selected Publications

Chen H and TH Lucas: Advances in DBS surgery. Advances in Functional Neurosurgery, Thieme. Anderson, W (eds.). Thieme, 1(1), 6 2018.

Liu X, H Zhu, M Zhang, AG Richardson, SY Sritharan, D Ge, Y Shu, TH Lucas, J Van der Spiegel: A fully integrated wireless sensor brain interface system to restore finger sensation. International symposium on circuits and systems 1, 5 2017.

Abdullah KG, Y Li, N Nayak, J Thawani, R Balu, TH Lucas: Long term utility and complication profile of open craniotomy for biopsy in patients with idiopathic encephalitis. J Clinical Neuroscience 37, 2017.

Liu X, M Zhang, M Honzhu, A Richardson, TH Lucas, J Van der Spiegel: Design of a closed-loop, bi-directional brain machine interface system with energy efficient neural feature extraction and PID control. IEEE Trans Biomed Circuits and Systems 11(4), 2017.

Richardson AG and TH Lucas: Brainstem neural interfaces for long term subcortical neuromodulation. Frontiers in Neuroscience in press, 2017.

Mallela A, K Abdullah, AG Richardson, TH Lucas: Subgaleal topical vancomycin reduces surgical site infections following craniotomy: an examination of over 350 surgeries at an academic medical center. Neurosurgery in press, 2017.

Ung H, B Litt, A Nanivadekar, C Cazares, L Kini, J Wagenaar, D Becker, M Kahana, TH Lucas, G Baltuch, M Sperling, A Sharan, K Davis: Spatial distribution of epileptiform spikes impacts visual word memory encoding. Brain 140(8), 2017.

Lucas TH, X Liu, M Zhang, S Sritharan, I Planell, Y Ghenbot, S Torres, C Brandon, J Van der Spiegel, AG Richardson: Strategies for autonomous sensor-brain interfaces for closed loop sensory reanimation of paralyzed limbs. Neurosurgery 64, 2017.

Spaethling J, YJ Na, J Lee, A Ulyanova, GH Baltuch, TJ Bell, S Brem, HI Chen, H Dueck, SA Fisher, M Garcia, M Khaladkar, DK Kung, TH Lucas, MD O'Rourke, D Stephnik, J Wank, JA Wolfe, T Bartfai, MS Grady, JY Sul, J Kim, JH Eberwine: Primary cell culture of live neurosurgical resected aged adult human brain cells and single cell transcriptomics. Cell Reports 18(3), 2017.

Ezzyat Y, JF Burke, DF Levy, A Lyalenko, MR Sperling, AD Sharan, GA Worrell, MT Kucewicz, BC Jobst, KA Davis, TH Lucas, RE Gross, BC Lega, JM Stein, S Das, R Gorniak, DS Rizzuto, MJ Kahana: Targeted brain stimulation to modulate memory performance in humans. Current Biology 27: 1251-8, 2017.

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Last updated: 09/01/2017
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