Juan E. Grunwald, MD
Professor of Ophthalmology at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia
Assistant in Ophthalmology
Attending Staff Physician
Director, Vivian S. Lasko Ocular Vascular Laboratory
Department: Ophthalmology
Contact information
SCHEIE EYE INSTITUTE
51 NORTH 39TH STREET
2689
Philadelphia, PA 19104
51 NORTH 39TH STREET
2689
Philadelphia, PA 19104
Office: 215-662-8675
Fax: 215-662-8025
Fax: 215-662-8025
Email:
juangrun@mail.med.upenn.edu
juangrun@mail.med.upenn.edu
Publications
Education:
M.D.
University of Tel-Aviv, Sackler Medical School, 1975.
M.D.
University of Tel-Aviv, Sackler Medical School, 1975.
Post-Graduate Training
Intern in Medicine, Hasharon Hospital, Petach-Tikva, Israel, 1974-1975.
Resident in Ophthalmology, Beilinson Medical Center, Petach-Tikva, Israel, 1975-1979.
Fellowship in Medical Retinal Diseases, University of Pennsylvania, Scheie Eye Institute, 1986-1987.
Intern in Medicine, Hasharon Hospital, Petach-Tikva, Israel, 1974-1975.
Resident in Ophthalmology, Beilinson Medical Center, Petach-Tikva, Israel, 1975-1979.
Fellowship in Medical Retinal Diseases, University of Pennsylvania, Scheie Eye Institute, 1986-1987.
Certifications
American Board of Ophthalmology, 1983.
Permanent linkAmerican Board of Ophthalmology, 1983.
Description of Research Expertise
Dr. Grunwald is world renowned for his research on blood flow in the retina. He has helped to develop techniques to measure the circulation in the eye. In his laboratory, the Vivian Simkins Lasko Retinal Vascular Research Laboratory, non-invasive state of the art technology is employed to study the role of circulatory changes in the development of vision-threatening eye diseases such as age-related macular degeneration (AMD), diabetic retinopathy, glaucoma, retinitis pigmentosa, and others and the pharmacologic effects of medications on the human ocular vasculature and its circulation.Clinical Trials
Dr. Grunwald is an investigator on the following trials:
•Complications of Age-Related Macular Degeneration Prevention Trial (CAPT)
•The Comparison of Age-Related Macular Degeneration Treatments Trials (CATT)
•Retinopathy in Chronic Renal Insufficiency (RCRIC)
He is the Principal Investigator of two grants that will quantitate changes occurring in the retina due to diabetic retinopathy, systemic hypertension and age-related macular degeneration.
Keywords
Age-related macular degeneration (AMD), choroidal circulation, diabetic retinopathy, ocular vasculature, optic nerve blood flow, pharmacologic effects, retina, retinal circulation, retinal vasculature
Description of Clinical Expertise
Dr. Grunwald cares for and treats patients with age-related macular degeneration, diabetic retinopathy and retinal vascular diseases at the following locations: Scheie Eye Institute, Hospital of the University of Pennsylvania, Penn Medicine at Radnor, Mercy Fitzgerald Hospital and the Veterans’ Administration Medical Center.Description of Other Expertise
Teaching. Fluency in Spanish, Hebrew and EnglishSelected Publications
Metelitsina, T.I., Grunwald, J.E., DuPont, J.C., Ying, G.S., Brucker, A.J., and Dunaief, J.L.: Foveolar choroidal blood flow and choroidal neovascularization in age related macular degeneration. Invest. Ophthalmol. And Vis. Sci. 49: 358-363, 2008.Rabinowitz, M.P., Grunwald, J.E., Karp, K.A., Quinn, G.E., Ying, G.S., and Mills, M.D.: Progression to severe retinopathy predicted by retinal vessel diameter between 31 and 34 weeks of post-conception age. Arch. Ophthalmol. 125: 1495-1500, 2007.
Metelitsina TI, Grunwald JE, DuPont JC, Ying G.: Effect of systematic hypertension on foveolar choroidal blood flow in age related macular degeneration. Brit. J. Ophthalmol. 90: 342-346, 2006.
Barakat M, Grunwald JE, Metelitsina TI, DuPont JC: Effect of niacin on retinal vascular diamter in patients with age-related macular degeneration (AMD). Current Eye Research in press, 2006.
Metelitsina TI, Grunwald JE, DuPont JC, Ying GS, Alexander J, Martin RE, Matsias KM: Association between age-related macular degeneration fundus features and foveolar choroidal circulation. Invest. Ophthalmol. Vis. Sci. 47: ARVO E-Abstract 2167, 2006.
Grunwald JE, Metelitsina TI, DuPont JC, Ying, GS: Decreases in the foveolar choroidal circulation precede the appearance of choroidal neovascularization in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 47: ARVO E-Abstract 2167, 2006.
Metelitsina TI, Grunwald JE, DuPont J, Ying G, Liu C: Effect of Viagra on retinal vessel diamter in AMD patients. Experimental Eye Research 81: 159-164, 2006.
Figueroa M, Schocket LS, DuPont J, Metelitsina TI, Grunwald JE: Long-term effect of laser treatment for dry age-related macular degeneration on choroidal hemodynamics. Am. J. Ophthalmol. 141: 863-867, 2006.
Sprinkle K, Mills MD, Karp KA, Grunwald JE: Quanitative analysis of retinal vessel diamter from digital fundus images of patients with retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 47: E-Abstract 5304, 2006.
Yan M, Huang K, Grunwald JE, Schuell H, Tyan J, Wachman B: Automatic detection of microaneurysms and/or hemorrhages from digital fundus photogrpahs of patients with diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 47: E-Abstract 4764, 2006.
