Myron Yanoff, MD
Adjunct Professor of Ophthalmology
Department: Ophthalmology
Contact information
Scheie Eye Institute
University of Pennsylvania
Department of Ophthalmology
51 North 39th Street
Philadelphia, PA 19104
University of Pennsylvania
Department of Ophthalmology
51 North 39th Street
Philadelphia, PA 19104
Publications
Education:
B.A.
University of Pennsylvania, Philadelphia, PA, 1957.
MD
University of Pennsylvania, 1961.
B.A.
University of Pennsylvania, Philadelphia, PA, 1957.
MD
University of Pennsylvania, 1961.
Post-Graduate Training
Rotating Intern, Methodist Hospital, Philadelphia, PA, 1961-1962.
Pathology Residency, Hospital of the University of Pennsylvania, 1962-1964.
Ophthalmology Residency, Hospital of the University of Pennsylvania, 1962-1967.
Ophthalmic Pathology Fellowship, Armed Forces Institute of Pathology, Washington, DC, 1964-1965.
Ophthalmic Pathology Special Fellow, Hopsital of the University of Pennsylvania, 1965-1967.
Retinal Fellowship, Wills Eye Hospital, Philadelphia, PA, 1967-1968.
Rotating Intern, Methodist Hospital, Philadelphia, PA, 1961-1962.
Pathology Residency, Hospital of the University of Pennsylvania, 1962-1964.
Ophthalmology Residency, Hospital of the University of Pennsylvania, 1962-1967.
Ophthalmic Pathology Fellowship, Armed Forces Institute of Pathology, Washington, DC, 1964-1965.
Ophthalmic Pathology Special Fellow, Hopsital of the University of Pennsylvania, 1965-1967.
Retinal Fellowship, Wills Eye Hospital, Philadelphia, PA, 1967-1968.
Certifications
Pathology (Anatomic), 1966.
Ophthalmology, 1969.
Permanent linkPathology (Anatomic), 1966.
Ophthalmology, 1969.
Description of Research Expertise
Most of Dr. Yanoff’s research revolves around finding the basic biochemical changes that cause diabetic retinopathy and age-related macular degeneration. Towards that end, his laboratory has been studying the regulatory effects of growth factors on choriocapillaris endothelial cells growth and survival. Dr. Yanoff’s laboratory also has been looking at the expression of apoptosis regulatory genes by retinal pericytes after rapid glucose reduction; artificial senescence of bovine retinal pigment epithelial cells induced by near-ultraviolet in vitro; and mRNA levels of antioxidant enzymes in pre-apoptotic pericytes from human diabetic retinas. His laboratory has shown that vascular endothelial growth factor regulates both apoptosis and angiogenesis of choriocapillaris endothelial cells. The studies are ongoing.Key Words
Age-related Macular Degeneration, ARMD, Diabetic Retinopathy
Selected Publications
Liu X, Yanoff M, Li W: Augmentation of trypsin resistance of RPE adhension in vitro by near ultraviolet. Ophthalmic Res 28: 2-7, 1996.Li W, Liu X, Yanoff M, Cohen S, Ye X: Cultured retinal capillary pericytes die by apoptosis after an abrupt fluctuation from hyperglycemia to hypoglycemia: a relevance of pericyte drop out in vivo. Dibetologia 39: 537-547, 1996.
Liu X, Ye X, Yanoff M, Li W: Extracellular matrix of retinal pigment epithelium regulates choriocapillaris endothelial survival in vitro. Exp Eye Res 65: 117-126, 1997.
Li W, Yanoff M, Liu X, Ye X: Retinal capillary pericyte apoptosis in early human diabetic retinopathy. Chin Med J 110: 659-663, 1997.
Li W, Liu X, He Z, Yanoff M, Jian B, Ye X: Expression of apoptosis regulatory genes by retinal pericytes after rapid glucose reduction. Invest Ophthalmol Vis Sci 39: 1535-1543, 1998.
Liu X, Ye X, Yanoff M, Li W: Regulatory effects of growth factors on choriocapillaris endothelial cells growth and survival. Ophthalmic Res 30: 302-313, 1998.
Li W, Liu X, He Z, Yanoff M, Jian B, Ye X: Expression of apoptosis regulatory genes by retinal pericytes after rapid glucose reduction. Invest Ophthalmol Vis Sci 39: 1535-1543, 1998.
Li W, Yanoff M, Li Y, He Z: Artificial senescence of bovine retinal pigment epithelial cells induced by near-ultraviolet in vitro. Mechanisms of Aging and Development 110: 137-155, 1999.
Li W, Yanoff M, Jian B, He Z: Altered mRNA levels of antioxyidant enzymes in pre-apoptotic pericytes from human diabetic retinas. Cell Molecular Biol 45: 59-65, 1999.
Li W, He Z, Yanoff: Vascular endothelial growth factor regulates both apoptosis and angiogenesis of choriocapillaris endothelial cells. Microvascular Res 59: 286, 2000.
