Artur V. Cideciyan, PhD
Research Associate Professor of Ophthalmology
Department: Ophthalmology
Contact information
Scheie Eye Institute
51 N. 39th Street
Philadelphia, PA 19104
51 N. 39th Street
Philadelphia, PA 19104
Office: 215-662-9986
Fax: 215-662-9388
Fax: 215-662-9388
Email:
cideciya@mail.med.upenn.edu
cideciya@mail.med.upenn.edu
Links
Web Page of Dr. Artur Cideciyan
Search PubMed for articles authored by Dr. Cideciyan
Graduate Group Affiliations Bioengineering
Web Page of Dr. Artur Cideciyan
Search PubMed for articles authored by Dr. Cideciyan
Graduate Group Affiliations Bioengineering
Education
B.S. (Mechanical Engineering)
University of Miami, 1986.
M.S. (Biomedical Engineering)
University of Miami, 1988.
Ph.D. (Biomedical Engineering)
University of Miami, 1992.
B.S. (Mechanical Engineering)
University of Miami, 1986.
M.S. (Biomedical Engineering)
University of Miami, 1988.
Ph.D. (Biomedical Engineering)
University of Miami, 1992.
Post-Graduate Training
Research Associate, Department of Ophthalmology, University of Miami, 1992-1993.
Permanent linkResearch Associate, Department of Ophthalmology, University of Miami, 1992-1993.
Description of Research Expertise
Dr. Cideciyan’s primary research interests involve understanding of disease mechanisms in human hereditary retinal degenerations and evaluation of mechanism-specific treatments in these blinding conditions. This is accomplished by the use of non-invasive surrogate measures of biochemical and morphological abnormalities of the retina and the RPE. Knowledge obtained from human retinopathies is also used to glean molecular foundations of normal human vision. Furthermore, studies performed in parallel with non-invasive experimental methods in animal models of these human diseases are used to determine the correspondence between the models and the patients, and pre-clinical therapeutic strategies are tested as appropriate.Research methods of the laboratory include imaging, electrophysiology and psychophysics as well as mathematical modeling and software development. Optical coherence tomography (OCT) based methods are used to define retinal structure and light scatter characteristics; autofluorescence imaging based methods are used to elucidate RPE abnormalities; electroretinogram (ERG) photoresponses and psychophysical methods are used understand global and local rod and cone photoreceptor dysfunction; and pupillary imaging is used to define post-retinal visual function.
Key Words
Retinal degeneration, photoreceptors, visual cycle, autofluorescence, lipofuscin, melanin, optical coherence tomography, dark adaptation, electroretinography, pupilometry, ABCA4, ABCR, RPE65
Selected Publications
Cideciyan AV, Swider M, Aleman TS, Roman MI, Sumaroka A, Schwartz SB, Stone EM, Jacobson SG.: Reduced-illuminance autofluorescence imaging in ABCA4-associated retinal degenerations. Journal of the Optical Society of America, A 24(5): 1457-67, 2007.Cideciyan AV, Jacobson SG, Aleman TS, Gu D, Pearce-Kelling SE, Sumaroka A, Acland GM, Aguirre GD.: In vivo dynamics of retinal injury and repair in the rhodopsin mutant dog model of human retinitis pigmentosa. Proceedings of the National Academy of Sciences USA 102(14): 5233-8, 2005.
Cideciyan AV, Swider M, Aleman TS, Sumaroka A, Schwartz SB, Roman MI, Milam AH, Bennett J, Stone EM, Jacobson SG.: ABCA4-associated retinal degenerations spare structure and function of the human parapapillary retina. Investigative Ophthalmology & Visual Science 46(12): 4739-46, 2005.
Cideciyan AV, Aleman TS, Swider M, Schwartz SB, Steinberg JD, Brucker AJ, Maguire AM, Bennett J, Stone EM, Jacobson SG. : Mutations in ABCA4 result in accumulation of lipofuscin before slowing of the retinoid cycle: A reappraisal of the human disease sequence. Human Molecular Genetics 13: 525-534, 2004.
Cideciyan AV, Jacobson SG, Gupta N, Osawa S, Locke KG, Weiss ER, Wright AF, Birch DG, Milam AH. : Cone deactivation kinetics and GRK1/GRK7 expression in enhanced S cone syndrome caused by mutations in NR2E3. Investigative Ophthalmology & Visual Science 44: 1268-1274, 2003.
Cideciyan AV, Haeseleer F, Fariss RN, Aleman TS, Jang G-F, Verlinde CLMJ, Marmor MF, Jacobson SG, Palczewski K.: Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man. Visual Neuroscience 17: 667-678, 2000.
Cideciyan AV, Zhao X, Nielsen L, Khani SC, Jacobson SG, Palczewski K. : Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man. Proceedings of the National Academy of Sciences USA 95: 328-333, 1998.
Cideciyan AV, Hood DC, Huang Y, Banin E, Li Z-Y, Stone EM, Milam AH, Jacobson SG.: Disease sequence from mutant rhodopsin allele to rod and cone photoreceptor degeneration in man. Proceedings of the National Academy of Sciences USA 95: 7103-7108, 1998.
Cideciyan AV. : Registration of ocular fundus images by cross-correlation of triple invariant image descriptors. IEEE Engineering in Medicine & Biology 14: 52-58, 1995.
Cideciyan AV and Jacobson SG. : Image analysis of the tapetal-like reflex in heterozygotes of X-linked retinitis pigmentosa. Investigative Ophthalmology & Visual Science. 35: 3812-3824, 1994.
