Joshua L. Dunaief, MD, PhD
Assistant Professor of Ophthalmology
Member
Member
Scientist
Member
Member
Department: Ophthalmology
Contact information
305 Stellar Chance
422 Curie Blvd.
Philadelphia, PA 19104-6100
422 Curie Blvd.
Philadelphia, PA 19104-6100
Office: 215-898-5235
Fax: 215-573-3918
Fax: 215-573-3918
Email:
jdunaief@mail.med.upenn.edu
jdunaief@mail.med.upenn.edu
Graduate Group Affiliations
Publications
Education
B.A. (Biology)
Harvard University (magna cum laude), 1987.
PhD
Columbia University, 1994.
MD
Columbia University, 1996.
B.A. (Biology)
Harvard University (magna cum laude), 1987.
PhD
Columbia University, 1994.
MD
Columbia University, 1996.
Post-Graduate Training
Intern in Internal Medicine, Mercy Hospital/University of Maryland, 1996-1997.
Resident in Ophthalmology, Wilmer Eye Institute, Johns Hopkins, Baltimore, 1997-2000.
Intern in Internal Medicine, Mercy Hospital/University of Maryland, 1996-1997.
Resident in Ophthalmology, Wilmer Eye Institute, Johns Hopkins, Baltimore, 1997-2000.
Certifications
American Board of Ophthalmology, 2001.
Permanent linkAmerican Board of Ophthalmology, 2001.
Description of Research Expertise
Research InterestsMechanisms of oxidative stress induced apoptosis in the retina
Key words: AMD, iron, oxidative stress, apoptosis, retina, aging, mitochondria.
Description of Research
Age related macular degeneration (AMD) is the most common cause of irreversible blindness, yet its pathogenesis is poorly understood. Evidence suggests that cumulative oxidative damage contributes to AMD and aging in general. My lab has found that AMD retinas have iron overload, which can increase oxidative stress. Increased understanding of retinal iron homeostasis may lead to treatments for AMD. To investigate the mechanisms of retinal iron regulation, we use transgenic mouse models, human retinal tissue, and a dual chamber tissue culture system to study iron transport. A mouse line deficient in the iron transporting ferroxidases ceruloplasmin and hephaestin develops age-dependent retinal iron overload and retinal degeneration with features of AMD (Hahn et al., PNAS, 2004). Recent research suggests that iron plays a key role in apoptosis induced by a variety of insults. Further investigation of the mechanisms of retinal iron homeostasis and of iron induced apoptosis are the focus of the lab.
Rotation Projects for 2006-2007
Recent results suggest that iron chelation confers remarkable protection from apoptosis initiated by a variety of insults. Lab rotations this year will focus on uncovering the role of iron in apoptosis in cultured mammalian cells.
Lab personnel:
Tzvete Dentchev, MD, Senior Research Specialist
Nina Lukinova, PhD, Senior Research Specialist
Paul Hahn, MD/PhD, post-doc and ophthamlology resident, Scheie Eye Institute
Jared Iacovelli, MS, graduate student
Chih King, graduate student
Nick Ligato, MS, post-masters student
Xining He, post-bac student
Majda Hadziahmetovic, post-doc
Predrag Krajacic, post-doc
Description of Clinical Expertise
age-related macular degeneration (AMD)

