University of Pennsylvania Health System

Department of Ophthalmology

Ophthalmology Faculty

John H. Kempen, MD, MPH, MHS, PhD

faculty photo
Professor of Ophthalmology
Attending Physician and Surgeon, Department of Ophthalmology/Scheie Eye Institute, Presbyterian Hospital
Attending Physician and Surgeon, Department of Ophthalmology, Hospital of the University of Pennsylvania
Director of Ocular Inflammation Service, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine
Director of Ophthalmic Epidemiology and International Ophthalmology , Department of Ophthalmology, University of Pennsylvania School of Medicine
Member, Center for Preventive Ophthalmology and Biostatistics
Member, University of Pennsylvania Graduate Group in Epidemiology and Biostatistics, University of Pennsylvania Graduate Group in Epidemiology and Biostatistics
Senior Scholar, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania
Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania
Department: Ophthalmology

Contact information
Ocular Inflammation Service
Scheie Eye Institute
51 N. 39th St
Philadelphia, PA 19104
Graduate Group Affiliations
Education:
BS (Biological Sciences, with Departmental Honors)
Stanford University, 1988.
MD (Medicine)
School of Medicine, University of California, San Diego, 1992.
MPH (International Health)
School of Hygiene & Public Health, Johns Hopkins University, 1997.
MHS (Biostatistics)
School of Hygiene and Public Health, Johns Hopkins University, 1999.
PhD (Epidemiology)
Bloomberg School of Public Health, Johns Hopkins University, 2001.
Post-Graduate Training
Intern, Transitional Residency Program, Santa Clara Valley Medical Center, San Jose, 1992-1993.
Resident in Ophthalmology, University of Washington, 1993-1996.
Fellow, Preventive Ophthalmology, Dana Center for Preventive Ophthalmology, The Wilmer Eye Institute, School of Medicine, The Johns Hopkins University, 1996-1997.
Fellow, Clinical Trials, Center for Clinical Trials, Department of Epidemiology, School of Hygiene & Public Health, The Johns Hopkins University, 1997-1998.
Fellow, Uveitis and Clinical Immunology, Ocular Immunology Service, The Wilmer Eye Institute, School of Medicine, The Johns Hopkins University, 1997-1998.
Certifications
American Board of Ophthalmology (Renewed 2007), 1997.
Permanent link
 
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Description of Research Expertise

Dr. Kempen is well-known nationally and internationally as an expert in ocular inflammatory diseases—such as uveitis, scleritis, and others—as well as ocular complications of AIDS. He is the Director of the Penn Ocular Inflammation Service, and Director of Ophthalmic Epidemiology at the Center for Preventive Ophthalmology and Biostatistics. As an expert epidemiologist, he holds a joint appointment in the Department of Biostatistics & Epidemiology, and the Penn Center for Clinical Epidemiology and Biostatistics.

Clinical Research
-Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study (funded by the National Eye Institute): Dr. Kempen is the national Principal Investigator for this study, the first NIH-sponsored multicenter clinical research study in the field of uveitis.
-Multicenter Uveitis Steroid Treatment (MUST) Trial (funded by the National Eye Institute): Dr. Kempen serves as International Vice-Chairman, as well as Director of the Penn Clinical Center enrolling patients in this study.
-Posurdex for Intermediate Uveitis, phase 3 Trial (funded by Allergan): Dr. Kempen directs the Penn clinical center for this study.
-Longitudinal Study of Ocular Complications of AIDS (funded by the National Eye Institute): Dr. Kempen is a co-investigator for this study.

Key words
Uveitis, iritis, pars planitis, panuveitis, sympathetic ophthalmia, choroiditis, retinitis, neuroretinitis, Vogt-Koyanagi-Harada disease, Fuchs’ heterochromic cyclitis, retinal vasculitis, serpiginous retinochoroiditis, birdshot chorioretinitis, immunosuppressive therapy for eye disease, scleritis, orbital inflammatory disease, ocular complications of AIDS, cytomegalovirus retinitis, acute retinal necrosis, infectious retinitis, toxoplasmic retinitis

Description of Clinical Expertise

Dr. Kempen serves as a regional clinician expert in ocular inflammatory diseases--such as uveitis and scleritis--for the Delaware Valley region of the United States, including Pennsylvania, New Jersey, Delaware and adjacent regions.

Selected Publications

Artornsombudh P, Pistilli M, Foster CS, Pujari SS, Gangaputra SS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Rosenbaum JT, Suhler EB, Thorne JE, Kempen JH: Factors predictive of remission of new-onset anterior uveitis Ophthalmology 121(3): 778-84, March 2014 Notes: doi: 10.1016/j.ophtha.2013.09.041. Epub 2013 Dec 15.

Baxter SL, Pistilli M, Pujari SS, Liesegang TL, Suhler EB, Thorne JE, Foster CS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Rosenbaum JT, Kempen JH: Risk of choroidal neovascularization among the uveitides Am J Ophthalmol 156(3): 468-477, Sep 2013 Notes: *Corresponding author. Epub 2013 Jun 21.

Kempen JH, Sugar EA, Jaffe GJ, Acharya NR, Dunn JP, Elner SG, Lightman SL, Thorne JE, Vitale AT, Altaweel MM; Multicenter Uveitis Steroid Treatment (MUST)Trial Research Group: Fluorescein Angiography versus Optical Coherence Tomography for Diagnosis of Uveitic Macular Edema. Ophthalmology 120(9): 1852-9, Sep 2013 Notes: *Corresponding author. doi:pii:S0161-6420(13)00115-2. 10.1016/j.ophtha.2013.01.069.

Friedman DS, Holbrook JT, Ansari H, Alexander J, Burke A, Reed S, Katz J, Thorne JE, Lightman SL, Kempen JH for the MUST Research Group: Risk of elevated intraocular pressure and glaucoma in patients with uveitis; results of the Multicenter Uveitis Steroid Treatment Trial. Ophthalmology 120(8): 1571-9, Aug 2013 Notes: Epub 2013 Apr 16.

Hsieh J, Honda AF, Surez-Farias M, Samson CM, Kedhar S, Mauro J, Francis J, Badamo J, Diaz VA, Kempen JH, Latkany PA: Fundus image diagnostic agreement in uveitis utilizing free and open source software. Can J Ophthalmol 48(4): 227-34, Aug 2013.

Lerman MA, Burnham JM, Chang PY, Daniel E, Foster CS, Hennessy S, Jabs DA, Joffe MM, Oktay Kaçmaz R, Levy-Clarke GA, Mills MD, Nussenblatt RB, Rosenbaum JT,Suhler EB, Thorne JE, Kempen JH: Response of Pediatric Uveitis to Tumor Necrosis Factor-α Inhibitors J Rheumatol 40(8): 1394-1403, Aug 2013 Notes: *Corresponding author. Epub 2013 Jul 1.

Gregory AC 2nd, Kempen JH, Daniel E, Kaçmaz RO, Foster CS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Rosenbaum JT, Suhler EB, Thorne JE; Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study Research Group.: Risk Factors for Loss of Visual Acuity among Patients with Uveitis Associated with Juvenile Idiopathic Arthritis: The Systemic Immunosuppressive Therapy for Eye Diseases Ophthalmology 120(1): 186-92, Jan 2013 Notes: Study doi: 10.1016/j.ophtha.2012.07.052. Epub 2012 Oct 11.

Mehta S, Hariharan L, Ho AC, Kempen JH: Peripapillary choroidal neovascularization in pars planitis. Journal of Ophthalmic Inflammation and Infection 15;3(1):13. . PubMed PMID: ; PubMed Central PMCID: . 15(3 (1)): 13, Jan 2013 Notes: doi: 10.1186/1869-5760-3-13

Domalpally A, Altaweel MM, Kempen JH, Myers D, Davis JL, Foster CS, Latkany P, Srivastava SK, Stawell RJ, Holbrook JT; For the MUST Trial Research Group: Optical Coherence Tomography Evaluation in the Multicenter Uveitis Steroid Treatment (MUST) Trial Dec;20(6):443-447 Ocul Immunol Inflamm 20(6): 443-447, Dec 2012 Notes: Epub 2012 Nov 19.

Kempen JH*, Sugar EA, Lyon AT, Lewis RA, Jabs DA, Heinemann MH, Dunn JP for the Studies of the Ocular Complications of AIDS: Risk of cataract in persons with cytomegalovirus retinitis and the acquired immune deficiency syndrome. Ophthalmology 119(11): 2343-50, Nov 2012 Notes: *Corresponding author. Epub 2012 Jul 30.

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Last updated: 07/24/2014
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