University of Pennsylvania Health System

Department of Ophthalmology

Ophthalmology Faculty

Faculty Overview

John H. Kempen, MD, MPH, MHS, PhD

faculty photo
Professor of Ophthalmology
Attending Physician and Surgeon, Department of Ophthalmology/Scheie Eye Institute, Presbyterian Hospital
Attending Physician and Surgeon, Department of Ophthalmology, Hospital of the University of Pennsylvania
Director of Ocular Inflammation Service, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine
Director of Ophthalmic Epidemiology and International Ophthalmology , Department of Ophthalmology, University of Pennsylvania School of Medicine
Member, Center for Preventive Ophthalmology and Biostatistics
Member, University of Pennsylvania Graduate Group in Epidemiology and Biostatistics, University of Pennsylvania Graduate Group in Epidemiology and Biostatistics
Senior Scholar, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania
Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania
Department: Ophthalmology

Contact information
Ocular Inflammation Service
Scheie Eye Institute
51 N. 39th St
Philadelphia, PA 19104
Education:
BS (Biological Sciences, with Departmental Honors)
Stanford University, 1988.
MD (Medicine)
School of Medicine, University of California, San Diego, 1992.
MPH (International Health)
School of Hygiene & Public Health, Johns Hopkins University, 1997.
MHS (Biostatistics)
School of Hygiene and Public Health, Johns Hopkins University, 1999.
PhD (Epidemiology)
Bloomberg School of Public Health, Johns Hopkins University, 2001.
Post-Graduate Training
Intern, Transitional Residency Program, Santa Clara Valley Medical Center, San Jose, 1992-1993.
Resident in Ophthalmology, University of Washington, 1993-1996.
Fellow, Preventive Ophthalmology, Dana Center for Preventive Ophthalmology, The Wilmer Eye Institute, School of Medicine, The Johns Hopkins University, 1996-1997.
Fellow, Uveitis and Clinical Immunology, Ocular Immunology Service, The Wilmer Eye Institute, School of Medicine, The Johns Hopkins University, 1997-1998.
Fellow, Clinical Trials, Center for Clinical Trials, Department of Epidemiology, School of Hygiene & Public Health, The Johns Hopkins University, 1997-1998.
Certifications
American Board of Ophthalmology (Renewed 2007), 1997.
Permanent link
 
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Description of Research Expertise

Dr. Kempen is well-known nationally and internationally as an expert in ocular inflammatory diseases—such as uveitis, scleritis, and others—as well as ocular complications of AIDS. He is the Director of the Penn Ocular Inflammation Service, and Director of Ophthalmic Epidemiology at the Center for Preventive Ophthalmology and Biostatistics. As an expert epidemiologist, he holds a joint appointment in the Department of Biostatistics & Epidemiology, and the Penn Center for Clinical Epidemiology and Biostatistics. Dr. Kempen also is engaged in international research in India and Ethiopia regarding ophthalmic epidemiology and trachoma research.

Clinical Research
-Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study (funded by the National Eye Institute): Dr. Kempen is the national Principal Investigator for this study, the first NIH-sponsored multicenter clinical research study in the field of uveitis.
-Multicenter Uveitis Steroid Treatment (MUST) Trial Follow-up Study(funded by the National Eye Institute): Dr. Kempen serves as International Vice-Chairman for the MUST Network, Protocol Chair for the MUST Trial Follow-up Study, and Director of the Penn Clinical Center enrolling patients in this study.

Key words
Uveitis, iritis, pars planitis, panuveitis, sympathetic ophthalmia, choroiditis, retinitis, neuroretinitis, Vogt-Koyanagi-Harada disease, Fuchs’ heterochromic cyclitis, retinal vasculitis, serpiginous retinochoroiditis, birdshot chorioretinitis, immunosuppressive therapy for eye disease, scleritis, orbital inflammatory disease, ocular complications of AIDS, cytomegalovirus retinitis, acute retinal necrosis, infectious retinitis, toxoplasmic retinitis, trachoma, international ophthalmology, Ethiopia, India

Description of Clinical Expertise

Dr. Kempen serves as a regional clinician expert in ocular inflammatory diseases--such as uveitis and scleritis--for the Delaware Valley region of the United States, including Pennsylvania, New Jersey, Delaware and adjacent regions.

Description of Other Expertise

Dr. Kempen is Co-Founder and President of Sight for Souls, a US 501(c)(3) charity developing self-sustaining, tertiary eye institutes in developing countries as a strategy to address global blindness through self-sustaining service delivery, public health outreach, training and research. Approximately 80% of global blindness and low vision requires individual-level clinical care, which is directly addressed by this strategy.

Selected Publications

Sen HN, Abreu FM, Louis TA, Sugar EA, Altaweel MM, Elner SG, Holbrook JT, Jabs DA, Kim RY, Kempen JH; Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study Research Group: Cataract Surgery Outcomes in Uveitis: The Multicenter Uveitis Steroid Treatment Trial. Ophthalmology 123(1), Jan 2016 Notes: Epub 2015 Oct 20

Kempen JH, Van Natta ML, Altaweel MM, Dunn JP, Jabs DA, Lightman SL, Thorne JE, Holbrook JT; Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group: Factors Predicting Visual Acuity Outcome in Intermediate, Posterior and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial. Am J Ophthalmol 160(6): 1133-1141, Dec 2015 Notes: Epub 2015 Sep 18.

Patel AK, Newcomb CW, Liesegang TL, Pujari SS, Suhler EB, Thorne JE, Foster CS, Jabs DA, Levy-Clarke GA, Nussenblatt RB, Rosenbaum JT, Sen HN, Artornsombudh P, Kothari S, Kempen JH: Risk of Retinal Neovascularization In Cases of Uveitis. Ophthalmology 6420(15): 01279-8, Dec 2015 Notes: [Epub ahead of print]

Li J, Orlin SE, Revere KE, Kempen JH: Acute onset anterior uveitis after darbepoetin alfa infusion. J Ophthalmic Inflamm Infect 5(1): 31, Dec 2015 Notes: Epub 2015 Oct 26.

Subburaman GB, Hariharan L, Ravilla TD, Ravilla RD, Kempen JH: Demand for Tertiary Eye Care Services in Developing Countries. Am J Ophthalmol 160(4): 619-627, Oct 2015 Notes: Epub 2015 Jun 19.

The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study Research Group. (Writing Committee: Kempen JH (Chair), Altaweel MM, Drye LT, Holbrook JT, Jabs DA, Sugar EA, Thorne JE): Benefits of systemic anti-inflammatory therapy versus fluocinolone acetonide intraocular implant for intermediate, posterior and panuveitis: 54 month results of The Multicenter Uveitis Steroid Treatment Trial (MUST) and Follow-up Study. Ophthalmology 122(10): 1967-75, Oct 2015 Notes: Epub 2015 Aug 20.

The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study Research Group.(Writing Committee: Kempen JH (Chair), Altaweel MM, Drye LT, Holbrook JT, Jabs DA, Sugar EA, Thorne JE): Quality of life and risks associated with systemic anti-inflammatory therapy versus fluocinolone acetonide intraocular implant for intermediate, posterior or panuveitis: 54 month results of The Multicenter Uveitis Steroid Treatment (MUST) trial and follow-up study Ophthalmology 122(10): 1979-86, Oct 2015 Notes: Epub 2015 Aug 19.

Tomkins-Netzer O, Lightman SL, Drye LT, Kempen JH, Holland GN, Rao NA, Stawell RJ, Vitale A, Jabs DA: Outcome of Treatment of Uveitic Macular Edema: The Multicenter Uveitis Steroid Treatment Trial 2-Year Results. Ophthalmology Sep 2015 Notes: Epub ahead of print.

Ganesh SK, Bala A, Biswas J, Ahmed AS, Kempen JH: Pattern of Pediatric Uveitis Seen at a Tertiary Referral Center from India. Ocul Immunol Inflamm 19: 1-8, Aug 2015 Notes: Epub ahead of print.

Lerman MA, Lewen MD, Kempen JH, Mills MD: Uveitis Reactivation in Children Treated With Tumor Necrosis Factor Alpha Inhibitors. Am J Ophthalmol 160(1): 193-200, Jul 2015 Notes: Epub 2015 Apr 17.

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Last updated: 01/20/2016
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