John H. Kempen, MD, PhD
Associate Professor of Ophthalmology
Attending Physician and Surgeon
Attending Physician and Surgeon
Director of Ocular Inflammation Service, Department of Ophthalmology
Director of Ophthalmic Epidemiology, Department of Ophthalmology
Senior Scholar, Center for Clinical Epidemiology and Biostatistics
Member, Institute for Translational Medicine and Therapeutics
Department: Ophthalmology
Contact information
Ocular Inflammation Service
Scheie Eye Institute
51 N. 39th St
Philadelphia, PA 19104
Scheie Eye Institute
51 N. 39th St
Philadelphia, PA 19104
Office: 215-662-8155
Fax: 215-243-4696
Fax: 215-243-4696
Email:
john.kempen@uphs.upenn.edu
john.kempen@uphs.upenn.edu
Graduate Group Affiliations
Publications
Education
BS (Biological Sciences)
Stanford University, 1988.
MD (Medicine)
School of Medicine, University of California, San Diego, 1992.
MPH (International Health)
School of Hygiene & Public Health, Johns Hopkins University, 1997.
MHS (Biostatistics)
School of Hygiene and Public Health, Johns Hopkins University, 1999.
PhD (Epidemiology)
Bloomberg School of Public Health, Johns Hopkins University, 2001.
BS (Biological Sciences)
Stanford University, 1988.
MD (Medicine)
School of Medicine, University of California, San Diego, 1992.
MPH (International Health)
School of Hygiene & Public Health, Johns Hopkins University, 1997.
MHS (Biostatistics)
School of Hygiene and Public Health, Johns Hopkins University, 1999.
PhD (Epidemiology)
Bloomberg School of Public Health, Johns Hopkins University, 2001.
Post-Graduate Training
Fellow, Uveitis and Clinical Immunology, Ocular Immunology Service, The Wilmer Eye Institute, School of Medicine, The Johns Hopkins University, 1997-1998.
Intern, Transitional Residency Program, Santa Clara Valley Medical Center, San Jose, 1992-1993.
Resident in Ophthalmology, University of Washington, 1993-1996.
Fellow, Preventive Ophthalmology, Dana Center for Preventive Ophthalmology, The Wilmer Eye Institute, School of Medicine, The Johns Hopkins University, 1996-1997.
Fellow, Clinical Trials, Center for Clinical Trials, Department of Epidemiology, School of Hygiene & Public Health, The Johns Hopkins University, 1997-1998.
Fellow, Uveitis and Clinical Immunology, Ocular Immunology Service, The Wilmer Eye Institute, School of Medicine, The Johns Hopkins University, 1997-1998.
Intern, Transitional Residency Program, Santa Clara Valley Medical Center, San Jose, 1992-1993.
Resident in Ophthalmology, University of Washington, 1993-1996.
Fellow, Preventive Ophthalmology, Dana Center for Preventive Ophthalmology, The Wilmer Eye Institute, School of Medicine, The Johns Hopkins University, 1996-1997.
Fellow, Clinical Trials, Center for Clinical Trials, Department of Epidemiology, School of Hygiene & Public Health, The Johns Hopkins University, 1997-1998.
Certifications
American Board of Ophthalmology (Renewed 2007), 1997.
Permanent linkAmerican Board of Ophthalmology (Renewed 2007), 1997.
Description of Research Expertise
Dr. Kempen is well-known nationally and internationally as an expert in ocular inflammatory diseases—such as uveitis, scleritis, and others—as well as ocular complications of AIDS. He is the Director of the Penn Ocular Inflammation Service, and Director of Ophthalmic Epidemiology at the Center for Preventive Ophthalmology and Biostatistics. As an expert epidemiologist, he holds a joint appointment in the Department of Biostatistics & Epidemiology, and the Penn Center for Clinical Epidemiology and Biostatistics.Clinical Research
-Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Cohort Study (funded by the National Eye Institute): Dr. Kempen is the national Principal Investigator for this study, the first NIH-sponsored multicenter clinical research study in the field of uveitis.
-Multicenter Uveitis Steroid Treatment (MUST) Trial (funded by the National Eye Institute): Dr. Kempen serves as International Vice-Chairman, as well as Director of the Penn Clinical Center enrolling patients in this study.
-Posurdex for Intermediate Uveitis, phase 3 Trial (funded by Allergan): Dr. Kempen directs the Penn clinical center for this study.
-Longitudinal Study of Ocular Complications of AIDS (funded by the National Eye Institute): Dr. Kempen is a co-investigator for this study.
Key words
Uveitis, iritis, pars planitis, panuveitis, sympathetic ophthalmia, choroiditis, retinitis, neuroretinitis, Vogt-Koyanagi-Harada disease, Fuchs’ heterochromic cyclitis, retinal vasculitis, serpiginous retinochoroiditis, birdshot chorioretinitis, immunosuppressive therapy for eye disease, scleritis, orbital inflammatory disease, ocular complications of AIDS, cytomegalovirus retinitis, acute retinal necrosis, infectious retinitis, toxoplasmic retinitis
Selected Publications
Daniel E, ffytche TJ, Sundar Rao PSS, Kempen JH, Diener-West M and Courtright P: Incidence of ocular morbidity among multibacillary leprosy patients during a two year course of multi-drug therapy. Br J Ophthalmol 90: 68-73, 2006.Kempen JH, Min Y-I, Freeman WR, Holland GN, Friedberg DN, Dieterich DT, Jabs DA for the Studies of Ocular Complications of AIDS Research Group: Risk of Immune Recovery Uveitis in Patients with AIDS and Cytomegalovirus Retinitis. Ophthalmology 113: 684-94, 2006.
Dunn JP, Yamashita A, Kempen JH, Jabs DA: Retinal vascular occlusion in patients infected with HIV. Retina 25: 759-766, 2005.
Thorne JE, Jabs DA, Peters GB, Hair D, Dunn JP, Kempen JH: Birdshot retinochoroidopathy: Ocular complications and visual impairment. Am J Ophthalmol 140: 45-51, 2005.
Thorne JE, Jabs DA, Qazi FA, Nguyen QD, Kempen JH, Dunn JP: Mycophenolate mofetil therapy for inflammatory eye disease. Ophthalmology 112: 1472-1477, 2005.
Semba RD, Martin BK, Kempen JH, Thorne JE, Wu AW for the Studies of Ocular Complications of AIDS Research Group: The impact of anemia on energy and physical functioning in individuals with acquired immunodeficiency syndrome. Arch Intern Med 165: 2229-2236, 2005.
Jabs DA, Holbrook JT, Van Natta ML, Clark R, Jacobson MA, Kempen JH, Murphy RL for the Studies of Ocular Complications of AIDS Research Group: Risk factors for mortality in patients with AIDS in the era of HAART. Ophthalmology 112: 771-779, 2005.
Bykhovskaya I, Thorne JE, Kempen JH, Dunn JP, Jabs DA: Vogt-Koyanagi-Harada disease: Clinical outcomes. Am J Ophthalmol 140: 677-678, 2005.
The Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol 140: 509-516, 2005.
Kempen JH, Jabs DA, Wilson LA, Dunn JP, West SK: Incidence of Cytomegalovirus (CMV) Retinitis in Second Eyes of Patients with Acquired Immune Deficiency Syndrome and Unilateral CMV Retinitis. Am J Ophthalmol 139(6): 1028-1034, June 2005.
