University of Pennsylvania Health System

Department of Ophthalmology

Ophthalmology Faculty

Faculty Overview

Jessica I.W. Morgan, Ph.D.

faculty photo
Assistant Professor of Ophthalmology
Research Associate, University of Pennsylvania
Department: Ophthalmology

Contact information
3400 Civic Center Blvd.
Ophthalmology 3rd floor WEST 3-113W
Philadelphia, PA 19104-6100
Office: 215-614-4196
Graduate Group Affiliations
Education:
BS (physics with honors)
Wake Forest University, 2002.
BA (Mathematics with honors)
Wake Forest University, 2002.
MS (Optical Engineering)
University of Rochester, 2005.
PhD (Optical Engineering)
University of Rochester, 2008.
Post-Graduate Training
Ophthalmology Postdoctoral Fellow, University of Pennsylvania, 2008-2011.
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Description of Research Expertise

Inherited retinal degenerations are a major cause of incurable blindness. As a group, these diseases are characterized by progressive death of the cone and rod photoreceptor cells of the retina leading to blindness. Over 150 different types of inherited retinal degenerations have been identified by clinical and genetic studies. Through exciting recent discoveries, researchers are entering an era in which genetic therapies can restore vision to patients with these diseases. However the success of gene therapies remains dependent upon the quantitative characterization of pre-treatment disease phenotype, the proper selection of trial patients most likely to benefit from the therapy, and the quantitative assessment of treatment outcome.

Dr. Morgan's primary research interest is to characterize the phenotypes of normal, diseased, and treated retinas in order to develop quantitative measures of disease progression and treatment efficacy. To do this, she uses high-resolution retinal imaging (including retinal densitometry, adaptive optics scanning laser ophthalmoscopy, and autofluorescence imaging) to study the structure and function of the retina non-invasively. These techniques allow quantitative characterization of the cone and retinal pigment epithelial cell mosaics on an individual cellular level, and a quantitative assessment of rhodopsin function in the rods.

Measuring retinal structure and function will allow the etiology of retinal diseases to be studied and will provide high-resolution quantitative outcome metrics for assessing treatment efficacy. These types of quantitative evaluations will be required to develop therapies that will be successful at preventing vision loss in the long-term.

Selected Publications

Han GK, Cooper R, Hsu JC, Chen M, Carroll J, Morgan JIW : Counting Cones in the Presence of Rods: A Reliability Study. Association for Research in Vision and Ophthalmology Annual Meeting 2016.

Chen, M; Cooper, RF; Han, GK; Gee, J; Brainard, DH; Morgan, JIW: Multi-modal Automatic Montaging of Adaptive Optics Retinal Images. Association for Research in Vision and Ophthalmology Annual Meeting 2016.

Morgan, JI; Han, GK; Cooper, RF; Pearson, D; Serrano, L; Bennett, J; Maguire, AM; Dubra, A; Aleman, TS: Cone Photoreceptor Inner and Outer Segment Mosaic Abnormalities in Choroideremia. Association for Research in Vision and Ophthalmology Annual Meeting 2016.

A. Traband, N.M. Fuerst, L. Serrano, G. Han, D. Pearson, K.E. Uzhazi, J.I.W. Morgan, J. Bennett, A.M. Maguire, T.S. Aleman : Natural History of the Central Structural Abnormalities in Choroideremia: Insights from a Cross-sectional Study. Association for Research in Vision and Ophthalmology Annual Meeting 2016.

Griffin, S; Roorda, A; Chung, MM; Song, H; Carroll, J; Morgan, JIW; Chui, TYP; Rosen, RB; Blodi, BA; Scott, IU; Duncan, JL: Adaptive Optics Scanning Laser Ophthalmoscopy (AOSLO) in Patients with Central Retinal Vein Occlusion (CRVO) and Cystoid Macular Edema (CME): A SCORE2 Ancillary Study. Association for Research in Vision and Ophthalmology Annual Meeting 2016.

Kim, BJ; Han, GK; Brucker, AJ; Dubra, A; Morgan, JIW: Longitudinal Imaging of Cone Inner and Outer Segment Mosaics in Central Serous Chorioretinopathy. Association for Research in Vision and Ophthalmology Annual Meeting 2016.

Fuerst NM, Serrano L, Han GK, Morgan JIW, Maguire AM, Leroy BP, Kim BJ, Aleman TS : Detailed Functional and Structural Phenotype of Bietti Crystalline Dystrophy Associated with Mutations in CYP4V2 Complicated by Choroidal Neovascularization Association for Research in Vision and Ophthalmology Annual Meeting 2016.

Bonafede, L., Ficicioglu, C., Serano, L., Han, G., Morgan, JIW, Mills, M., Forbes, B., Davidson, S., Binenbaum, G., Kaplan, P., Nichols, C., Verloo, P., Leroy, B., Maguire, A., Aleman, T. : Cobalamin C Deficiency Shows a Rapidly Progressing Maculopathy with Severe Photoreceptor and Ganglion Cell Loss. Invest Ophthalmol Vis Sci 56(13): 7875-87, Dec 2015.

McKay, KM, Harvey, Z, Han, GK, Dubra, A, Morgan, JIWM: Stimulus-evoked optical response of individual cones observed with adaptive optics scanning light ophthalmoscopy. Association for Research in Vision and Ophthalmology Annual Meeting May 2015.

Han, GK, Aleman, TS, Morgan JIW: Adaptive optics and high-resolution imaging of structure and function in retinitis pigmentosa patients with verses without a hyperautofluorescent ring. Association for Research in Vision and Ophthalmology Annual Meeting May 2015.

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Last updated: 02/10/2016
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