University of Pennsylvania Health System

Department of Ophthalmology

Ophthalmology Faculty

Venkata Ramana Murthy Chavali, Ph.D

faculty photo
Research Associate of Ophthalmology
Department: Ophthalmology

Contact information
422 Curie Blvd., 315 Stellar Chance Labs, University of Pennsylvania
Philadelphia, PA 19104
Education:
B.Sc. (Biotechnology)
Andhra University, Visakhapatnam, INDIA, 1999.
M.Sc. (Biotechnology)
Andhra University, Visakhapatnam, INDIA, 2001.
PhD (Molecular Virology)
Indian Institute of Technology Kharagpur, INDIA, 2007.
Post-Graduate Training
Postdoctoral Fellow, Ophthalmology, University of Michigan, Ann Arbor, 2006-2007.
Postdoctoral Fellow Employee, Ophthalmology, University of California San Diego, 2008-2011.
Postdoctoral Fellow, Ophthalmology, University of Pennsylvania, 2011-2012.
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Description of Research Expertise

Research in Ophthalmology; Developing animal models like mouse, zebrafish and pig models to study age-related macular degeneration, refractive error and retinal degeneration; Investigating the molecular mechanisms of gene mutations found through Gene Association studies.

Selected Publications

Sommer Jeffrey R, Chavali Venkata R M, Simpson Sean G, Ayyagari Radha, Petters Robert M: Cloning, characterization, and expression analysis of the pig (Sus scrofa) C1q tumor necrosis factor-related protein-5 gene. Molecular vision 18: 92-102, Jan 2012.

Cukras Catherine, Gaasterland Terry, Lee Pauline, Gudiseva Harini V, Chavali Venkata R M, Pullakhandam Raghu, Maranhao Bruno, Edsall Lee, Soares Sandra, Reddy G Bhanuprakash, Sieving Paul A, Ayyagari Radha: Exome analysis identified a novel mutation in the RBP4 gene in a consanguineous pedigree with retinal dystrophy and developmental abnormalities. PloS one 7(11): e50205, Nov 2012.

Naeem Muhammad Asif, Chavali Venkata R M, Ali Shahbaz, Iqbal Muhammad, Riazuddin Saima, Khan Shaheen N, Husnain Tayyab, Sieving Paul A, Ayyagari Radha, Riazuddin Sheikh, Hejtmancik J Fielding, Riazuddin S Amer: GNAT1 Associated with Autosomal Recessive Congenital Stationary Night Blindness. Investigative ophthalmology & visual science 53(3): 1353-61, Mar 2012.

Chavali Venkata R M, Khan Naheed W, Cukras Catherine A, Bartsch Dirk-Uwe, Jablonski Monica M, Ayyagari Radha: A CTRP5 gene S163R mutation knock-in mouse model for late-onset retinal degeneration. Human molecular genetics 20(10): 2000-14, May 2011.

Vasireddy Vidyullatha, Chavali Venkata R M, Joseph Victory T, Kadam Rajendra, Lin Jonathan H, Jamison Jeffrey A, Kompella Uday B, Reddy Geereddy Bhanuprakash, Ayyagari Radha: Rescue of photoreceptor degeneration by curcumin in transgenic rats with P23H rhodopsin mutation. PloS one 6(6): e21193, Jun 2011.

Chavali Venkata R M, Sommer Jeffrey R, Petters Robert M, Ayyagari Radha: Identification of a promoter for the human C1Q-tumor necrosis factor-related protein-5 gene associated with late-onset retinal degeneration. Investigative ophthalmology & visual science 51(11): 5499-507, Nov 2010.

Riazuddin S Amer, Shahzadi Amber, Zeitz Christina, Ahmed Zubair M, Ayyagari Radha, Chavali Venkata R M, Ponferrada Virgilio G, Audo Isabelle, Michiels Christelle, Lancelot Marie-Elise, Nasir Idrees A, Zafar Ahmad U, Khan Shaheen N, Husnain Tayyab, Jiao Xiaodong, MacDonald Ian M, Riazuddin Sheikh, Sieving Paul A, Katsanis Nicholas, Hejtmancik J Fielding: A mutation in SLC24A1 implicated in autosomal-recessive congenital stationary night blindness. American journal of human genetics 87(4): 523-31, Oct 2010.

Li Lin, Nakaya Naoki, Chavali Venkata R M, Ma Zhiwei, Jiao Xiaodong, Sieving Paul A, Riazuddin Sheikh, Tomarev Stanislav I, Ayyagari Radha, Riazuddin S Amer, Hejtmancik J Fielding: A mutation in ZNF513, a putative regulator of photoreceptor development, causes autosomal-recessive retinitis pigmentosa. American journal of human genetics 87(3): 400-9, Sep 2010.

Ghorai Suvankar, Chakrabarti Mrinmay, Roy Sobhan, Chavali Venkata Ramana Murthy, Bagchi Abhisek, Ghosh Ananta Kumar: Molecular characterization of genome segment 2 encoding RNA dependent RNA polymerase of Antheraea mylitta cytoplasmic polyhedrosis virus. Virology 404(1): 21-31, Aug 2010.

Chang Bo, Mandal Md Nawajes A, Chavali Venkata R M, Hawes Norman L, Khan Naheed W, Hurd Ronald E, Smith Richard S, Davisson Muriel L, Kopplin Laura, Klein Barbara E K, Klein Ronald, Iyengar Sudha K, Heckenlively John R, Ayyagari Radha: Age-related retinal degeneration (arrd2) in a novel mouse model due to a nonsense mutation in the Mdm1 gene. Human molecular genetics 17(24): 3929-41, Dec 2008.

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Last updated: 09/26/2014
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