Qin Liu, MD, PhD
Research Assistant Professor of Ophthalmology
Department: Ophthalmology
Contact information
F. M. Kirby Center for Molecular Ophthalmology
304 Stellar Chance Labs
422 Curie Blvd.
Philadelphia, PA 19104
304 Stellar Chance Labs
422 Curie Blvd.
Philadelphia, PA 19104
Office: 215-573-7866
Fax: 215-573-8083
Fax: 215-573-8083
Email:
qinliu3@mail.med.upenn.edu
qinliu3@mail.med.upenn.edu
Publications
Education
M.D.
Xuzhou Medical College, Jiangsu, China, 1988.
Ph.D.
Peking Union Medical College, Beijing, China, 1998.
M.D.
Xuzhou Medical College, Jiangsu, China, 1988.
Ph.D.
Peking Union Medical College, Beijing, China, 1998.
Post-Graduate Training
Postdoctoral Research Associate, Texas A & M, Institute of Ocular Pharmacology, 1998-1999.
Resident , Xuzhou Medical College Hospital, Jiangsu, China, 1988-1993.
Posdoctoral Fellow, Scheie Eye Institute, University of Pennsylvania, 1999-2001.
Postdoctoral Research Associate, Texas A & M, Institute of Ocular Pharmacology, 1998-1999.
Resident , Xuzhou Medical College Hospital, Jiangsu, China, 1988-1993.
Posdoctoral Fellow, Scheie Eye Institute, University of Pennsylvania, 1999-2001.
Certifications
Chinese Board of Ophthalmology, 1988.
Permanent linkChinese Board of Ophthalmology, 1988.
Description of Research Expertise
Research Interests- Molecular bases of retinal degenerations
- Cell biology of photoreceptor cells
Key words
Photoreceptor cells, retinal degenerations, animal models, retinitis pigmentosa, RP1, cilia, proteome
Description of Research
Dr. Liu’s research is focused on identifying the molecular bases of inherited retinal degenerations, cell biology of photoreceptor cells, generating animal models of and developing treatment approaches for these diseases. She is currently investigating the pathogenesis of one of the common forms of retinitis pigmentosa, RP1, and starting to test potential therapies for RP1 disease. Dr. Liu has recently identified the protein components of mouse photoreceptor sensory cilium (PSC) by using proteomic analysis. The PSC is comprised of the outer segment and its cytoskeleton, including the ciliary rootlet, basal body and axoneme. Mutations in genes that encode PSC proteins are common causes of inherited retinal degenerations. The PSC proteome contains many novel photoreceptor and cilium proteins. These data will help elucidate the cell biology of photoreceptor cells and other primary cilia, and improve our understanding of the pathogenesis of diseases caused by cilia dysfunction.
Selected Publications
Bowne SJ, Liu Q, Sullivan LS, Zhu J, Spellicy CJ, Rickman CB, Pierce EA, Daiger SP: Why do mutations in the ubiquitously expressed Housekeeping gene IMPDH1 cause retina-specific photoreceptor degeneration? Invest Ophthalmol Vis Sci 47: 3754-3757, 2006.Liu Q, Zuo J, Pierce EA. : The retinitis pigmentosa 1 protein is a photoreceptor MAP. Journal of Neuroscience 24: 6427-3436, 2004.
Ma H, Liu Q, Diamond SL, Pierce EA. : Mouse embryonic stem cells efficiently lipofected with nuclear localization peptide result in a high yield of chimeric mice and retain germline transmission potency. Methods 33: 113-120, 2004.
Liu Q, Lyubarsky AL, Skelet J, Pugh EN Jr., Pierce EA. : RP1 is required for the correct stacking of outer segment discs. Invest Ophthalmol Vis Sci. 44: 4171-4183, 2003.
Pierce EA, Liu Q, Igoucheva O, Omarrudin R, Ma H, Diamond SL, Yoon K. : Oligonucleotide-directed single-base DNA alterations in mouse embryonic stem cells. Gene Therapy. 2003; 10(1):24-33. Gene Therapy 10(1): 24-33, 2003.
Gao J, Cheon K, Nusinowitz S, Liu Q, Bei D, Atkins K, Azimi A, Daiger SP, Farber DB, Heckenlively JR, Pierce EA, Sullivan LS, Zuo J. : Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene. Proc Natl Acad Sci U S A. 99(8): 5698-5703, 2002.
Liu Q, Zhou J, Daiger SP, Farber DB, Heckenlively JR, Smith JE, Sullivan LS, Zuo J, Milam AH, Pierce EA. : Identification and subcellular localization of the RP1 protein in human and mouse photoreceptors. Invest Ophthalmol Vis Sci 43(1): 22-32, 2002.
Beauregard C, Liu Q, Chiou GCY. : Effects of nitric oxide donors and nitric oxide synthase substrates on ciliary muscle contracted by carbachol and endothelin for possible uses in myopia prevention. J of Ocular Pharmacology and Therapeutics 17(1): 1-9, 2001.
Liu Q, Zhou Y, Xuan B, Chiou GCY, and Okawara T. : Effects of interleukin-1 blockers on corneal fibroblast proliferation in vitro and ocular inflammation in vivo. J of Ocular Pharmacology and Therapeutics 16(1): 81-96, 2000.
