Qin Liu, MD, PhD
Research Assistant Professor of Ophthalmology
Department: Ophthalmology
Contact information
F. M. Kirby Center for Molecular Ophthalmology
304 Stellar Chance Labs
422 Curie Blvd.
Philadelphia, PA 19104
304 Stellar Chance Labs
422 Curie Blvd.
Philadelphia, PA 19104
Office: 215-573-7866
Fax: 215-573-8083
Fax: 215-573-8083
Email:
qinliu3@mail.med.upenn.edu
qinliu3@mail.med.upenn.edu
Publications
Education:
M.D.
Xuzhou Medical College, Jiangsu, China, 1988.
Ph.D.
Peking Union Medical College, Beijing, China, 1998.
M.D.
Xuzhou Medical College, Jiangsu, China, 1988.
Ph.D.
Peking Union Medical College, Beijing, China, 1998.
Post-Graduate Training
Resident , Xuzhou Medical College Hospital, Jiangsu, China, 1988-1993.
Postdoctoral Research Associate, Texas A & M, Institute of Ocular Pharmacology, 1998-1999.
Postdoctoral Fellow, Scheie Eye Institute, University of Pennsylvania, 1999-2001.
Resident , Xuzhou Medical College Hospital, Jiangsu, China, 1988-1993.
Postdoctoral Research Associate, Texas A & M, Institute of Ocular Pharmacology, 1998-1999.
Postdoctoral Fellow, Scheie Eye Institute, University of Pennsylvania, 1999-2001.
Certifications
Chinese Board of Ophthalmology, 1988.
Permanent linkChinese Board of Ophthalmology, 1988.
Description of Research Expertise
Research Interests- Molecular bases of retinal degenerations
- Cell biology of photoreceptor cells
Key words
Photoreceptor cells, retinal degenerations, animal models, retinitis pigmentosa, RP1, cilia, proteome
Description of Research
Dr. Liu’s research is focused on identifying the molecular bases of inherited retinal degenerations, cell biology of photoreceptor cells, generating animal models of and developing treatment approaches for these diseases. She is currently investigating the pathogenesis of one of the common forms of retinitis pigmentosa, RP1, and starting to test potential therapies for RP1 disease. Dr. Liu has recently identified the protein components of mouse photoreceptor sensory cilium (PSC) by using proteomic analysis. The PSC is comprised of the outer segment and its cytoskeleton, including the ciliary rootlet, basal body and axoneme. Mutations in genes that encode PSC proteins are common causes of inherited retinal degenerations. The PSC proteome contains many novel photoreceptor and cilium proteins. These data will help elucidate the cell biology of photoreceptor cells and other primary cilia, and improve our understanding of the pathogenesis of diseases caused by cilia dysfunction.
Selected Publications
Liu Q, Saveliev A, Pierce EA.: The Severity of Retinal Degeneration in Rp1h Gene Targeted Mice is Dependent Upon Genetic Background. Invest Ophthalmol Vis Sci. Dec 2008.Liu Q, Tan G, Levenkova N, Li T, Pugh EN jr., Rux J, Speicher D, Pierce EA: The Proteome of the mouse photoreceptor sensory cilium complex. Molecular & Cellular Proteomics 6: 1299-1317, 2007.
Spellicy CJ, Daiger SP, Sullivan LS, Zhu J, Liu Q, Pierce EA, Bowne SJ.: Characterization of retinal inosine monophosphate dehydrogenase 1 in several mammalian species. Mol Vis. 3(13): 1866-72, 2007.
Bowne SJ*, Liu Q*, Sullivan LS, Zhu J, Spellicy CJ, Rickman CB, Pierce EA, Daiger SP: Why do mutations in the ubiquitously expressed Housekeeping gene IMPDH1 cause retina-specific photoreceptor degeneration? Invest Ophthalmol Vis Sci 47: 3754-3757, 2006 Notes: * indicates equal first authors.
Ma H, Liu Q, Diamond SL, Pierce EA. : Mouse embryonic stem cells efficiently lipofected with nuclear localization peptide result in a high yield of chimeric mice and retain germline transmission potency. Methods 33: 113-120, 2004.
Liu Q, Zuo J, Pierce EA. : The retinitis pigmentosa 1 protein is a photoreceptor MAP. Journal of Neuroscience 24: 6427-3436, 2004.
Bowne SJ, Daiger SP, Malone KA, Hechenlively JR, Kennan A, Humphries, P, Hughbanks-Wheaton D, Birch DG, Liu Q, Pierce EA, Zuo J, Huang Q, Sullivan LS.: Characterization of RP1L1, a highly polymorphic paralog of the retinitis pigmentosa 1 (RP1) gene. Molecular Vision 9: 129-137, 2003.
Liu Q, Lyubarsky AL, Skelet J, Pugh EN Jr., Pierce EA. : RP1 is required for the correct stacking of outer segment discs. Invest Ophthalmol Vis Sci. 44: 4171-4183, 2003.
Pierce EA, Liu Q, Igoucheva O, Omarrudin R, Ma H, Diamond SL, Yoon K. : Oligonucleotide-directed single-base DNA alterations in mouse embryonic stem cells. Gene Therapy. 2003; 10(1):24-33. Gene Therapy 10(1): 24-33, 2003.
Liu Q, Zhou J, Daiger SP, Farber DB, Heckenlively JR, Smith JE, Sullivan LS, Zuo J, Milam AH, Pierce EA. : Identification and subcellular localization of the RP1 protein in human and mouse photoreceptors. Invest Ophthalmol Vis Sci 43(1): 22-32, 2002.
