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Charles C. Clark, Ph.D.

Emeritus Associate Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
University of Pennsylvania
Department of Orthopaedic Surgery
424 Stemmler Hall
Philadelphia, PA 19104-6081
B.A. (Chemistry)
Gannon University, Erie, PA, 1965.
Ph.D. (Biochemistry)
Northwestern University, Chicago, IL, 1970.
Post-Graduate Training
NIH Postdoctoral Fellow, Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, 1970-1972.
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Selected Publications

Li D., Clark CC., Myers JC.: Basement membrane zone type XV collagen is a disulfide-bonded chondroitin sulfate proteoglycan in human tissues and cultured cells. Journal of Biological Chemistry 275(29): 22339-47, Jul 21 2000.

Myers JC., Li D., Rubinstein NA., Clark CC.: Up-regulation of type XIX collagen in rhabdomyosarcoma cells accompanies myogenic differentiation. Experimental Cell Research 253(2): 587-98, Dec 15 1999.

Jones AR., Brighton CT., Clark CC.: Collagen production by microvascular pericytes in long term culture. Trans. Orthop. Res. Soc. 16: 401, 1997.

Chesmel KD., Clark CC., Brighton CT., Black J.: Cellular responses to chemical and morphologic aspects of biomaterial surfaces. II. The biosynthetic and migratory response of bone cell populations. Journal of Biomedical Materials Research 29(9): 1101-10, Sep 1995.

Jones AR., Clark CC., Brighton CT.: Microvessel endothelial cells and pericytes increase proliferation and repress osteoblast phenotypic markers in rat calvarial bone cell cultures. Journal of Orthopaedic Research 13(4): 553-61, Jul 1995.

Bulman WA., Iannotti JP., Glowacki K., Bleuit J., Clark CC.: Serum fractions and related agonists with calcium-mobilizing activity in the bovine growth plate chondrocyte. Journal of Orthopaedic Research 13(2): 220-9, Mar 1995.

Nelson CL., Knight KZ., Clark CC.: The role of type I collagen in osteoblast differentiation. Trans. Orthop. Res. Soc. 20: 460, 1995.

Clark CC., Iannotti JP., Misra S., Richards CF.: Effects of thapsigargin, an intracellular calcium-mobilizing agent, on synthesis and secretion of cartilage collagen and proteoglycan. Journal of Orthopaedic Research 12(5): 601-11, Sep 1994.

Clark CC., Cohen I., Eichstetter I., Cannizzaro LA., McPherson JD., Wasmuth JJ., Iozzo RV.: Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. Genomics 18(2): 249-60, Nov 1993.

Richardson DW., Clark CC.: Effects of short-term cast immobilization on equine articular cartilage. American Journal of Veterinary Research 54(3): 449-53, Mar 1993.

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Last updated: 02/04/2009
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