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Masahiro Iwamoto, Ph.D., D.D.S.

Research Associate Professor of Orthopaedic Surgery
Scientist II, The Children's Hospital of Philadelphia Research Institute
Department: Orthopaedic Surgery

Contact information
The Children's Hospital of Philadelphia
Translational Research Program in Pediatric Orthopaedics
Division of Orthopaedic Surgery
Department of Surgery
3615 Civic Center Boulevard
Abramson Research Center 910A
Philadelphia, PA 19104
Office: 267-425-2072
Fax: 267-426-2215
D.D.S (Dental School)
Tokushima, 1984.
Ph.D (Dentistry)
Osaka University, 1988.
Post-Graduate Training
Clinical Staff, Osaka University Dental Hospital Department of Radiology, 1988-1990.
Postdoctoral Fellow, University of Pennsylvania, School of Dental Medicine Department of Anatomy & Histology, 1990-1993.
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> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Developmental biology of bone and cartilage.
Tissue degeneration of skeletal tissue and muscle.
Microsurgery of small animals.

Selected Publications

Sinha, S., Uchibe, K., Usami, Y., Pacifici, M., Iwamoto, M.: Effectiveness and mode of action of a combination therapy for heterotopic ossification with a retinoid agonist and an anti-inflammatory agent. Bone Feb 2016 Notes: doi: 10.1016/j.bone.2016.02.008.

Zhang, K., Asai, S., Hast, M. W., Liu, M., Usami, Y., Iwamoto, M., Soslowsky, L. J., Enomoto-Iwamoto, M.: Tendon mineralization is progressive and associated with deterioration of tendon biomechanical properties, and requires BMP-Smad signaling in the mouse Achilles tendon injury model. Matrix Biol 2016 Notes: 10.1016/j.matbio.2016.01.015.

Usami, Y., Gunawardena, A. T., Iwamoto, M., Enomoto-Iwamoto, M.: Wnt signaling in cartilage development and diseases: lessons from animal studies. Lab invest 96(2): 186-96, 2016.

Chakkalakal, S. A., Uchibe, K., Convente, M. R., Zhang, D., Economides, A. N., Kaplan, F. S., Pacifici, M., Iwamoto, M., Shore, E. M.: Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1 Fibrodysplasia Ossificans Progressiva (FOP) Mutation. J Bone Miner Res 2016 Notes: 10.1002/jbmr.2820.

Usami Y, Gunawardena AT, Iwamoto M, Enomoto-Iwamoto M.: Wnt signaling in cartilage development and diseases: lessons from animal studies. Lab Invest. Page: doi: 10.1038/labinvest.2015.142 (ePub ahead of print), Dec 2015.

Usami Yu, Gunawardena Aruni T, Iwamoto Masahiro, Enomoto-Iwamoto Motomi: Wnt signaling in cartilage development and diseases: lessons from animal studies. Laboratory investigation; a journal of technical methods and pathology Dec 2015.

Ohta Yoichi, Okabe Takahiro, Larmour Colleen, Di Rocco Agnese, Maijenburg Marijke W, Phillips Amanda, Speck Nancy A, Wakitani Shigeyuki, Nakamura Takashi, Yamada Yoshihiko, Enomoto-Iwamoto Motomi, Pacifici Maurizio, Iwamoto Masahiro: Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg. Arthritis & rheumatology (Hoboken, N.J.) 67(10): 2679-90, Oct 2015.

Di Rocco Agnese, Uchibe Kenta, Larmour Colleen, Berger Rebecca, Liu Min, Barton Elisabeth R, Iwamoto Masahiro: Selective Retinoic Acid Receptor γ Agonists Promote Repair of Injured Skeletal Muscle in Mouse. The American journal of pathology 185(9): 2495-504, Sep 2015.

Nakamura Takashi, Naruse Masahiro, Chiba Yuta, Komori Toshihisa, Sasaki Keiichi, Iwamoto Masahiro, Fukumoto Satoshi: Novel hedgehog agonists promote osteoblast differentiation in mesenchymal stem cells. Journal of cellular physiology 230(4): 922-9, Apr 2015.

Candela Maria Elena, Yasuhara Rika, Iwamoto Masahiro, Enomoto-Iwamoto Motomi: Resident mesenchymal progenitors of articular cartilage. Matrix biology : journal of the International Society for Matrix Biology 39: 44-9, Oct 2014.

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Last updated: 04/08/2016
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