Penn Orthopaedics

Orthopaedic Surgery Faculty

faculty photo

Motomi Enomoto-Iwamoto, D.D.S, Ph.D.

Research Associate Professor of Orthopaedic Surgery
Department: Orthopaedic Surgery

Contact information
The Children's Hospital of Philadelphia
Translational Research Program in Pediatric Orthopaedics
Division of Orthopaedic Surgery
Department of Surgery
3615 Civic Center Boulevard
Abramson Research Center 902A
Philadelphia, PA 19104
Office: 267-425-2071
Fax: 267-426-2215
Osaka University, 1983.
Ph.D. (Biochemistry)
Osaka University , 1987.
Post-Graduate Training
Post-Doctoral Fellow, Osaka University, Japan, 1987-1988.
Post-Doctoral Fellow in Microbiology, University of Pennsylvania, 1989-1992.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Cartilage development and pathology, tendon biology

Selected Publications

Zhang K, Asai S, Yu B, Enomoto-Iwamoto M: IL-1b Irreversibly Inhibits Tenogenic Differentiation and Alters Metabolism In Injured Tendon-Derived Progenitor Cells In Vitro. Biochem Biophys Res Commun 463(4): 667-672, 2015.

Huegel J, Enomoto-Iwamoto M, Sgariglia F, Koyama E, Pacifici M: Heparanase stimulates chondrogenesis and is up-regulated in human ectopic cartilage: a mechanism possibly involved in hereditary multiple exostoses. Am J Pathol 185(6): 1676-1685, 2015.

Usami Y, Gunawardna AF, Iwamoto M and Enomoto-Iwamoto M: Wnt signaling in cartilage development and diseases: Lessons from Animal Studies. Lab Invest, in press 2015.

Ohta Y, Okabe T, Larmour C, Di Rocco A, Maijenburg M, Phillips A, Speck NA, Wakitani S, Nakamura T, Yamada Y, Enomoto-Iwamoto M, Pacifici M, Iwamoto M: Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg. Arthritis Rheumatol 2015.

Maria Elena Candela, Leslie Cantley, Rika Yasuaha, Masahiro Iwamoto, Maurizio Pacifici, and Motomi Enomoto-Iwamoto : Distribution of Slow-Cycling Cells in Epiphyseal Cartilage and Requirement of β-Catenin Signaling for Their Maintenance in Growth Plate. J Orthop Res 32(5): 661-668, 2014.

Asai S, Otsuru S, Cahdela ME, Cantely L, Uchibe K, Hofmann TJ, Zhang K, Wapner KL, Soslwosky L, Horwitz EM and Enomoto-Iwamoto M: Tendon Progenitor cells in injured tendons have a strong chondrogenic potential: The CD105-negative subpopulation induces chondrogenic degeneration. Stem Cells 32(12): 3266-3277, 2014.

Zhang X, Zhu J, Liu F, Li Y, Chandra A, Levin LS, Beier F, Enomoto-Iwamoto M, and Qui L: Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone Research 2, 2014.

Candela EM, Yasuhara R, Iwamoto and Enomoto-Iwamoto M: Resident mesenchymal progenitors of articular cartilage. Matrix Biol 39: 44-49, 2014.

Decker RS, Koyama E, Enomoto-Iwamoto M, Maye P, Rowe D, Zhu S, Schultz PG, Pacifici M: Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin. Dev Biol 395(2): 255-267, 2014.

Sgariglia F, Pedrini E, Bradfield JP, Bhatti TR, D'Adamo P, Dormans JP, Gunawardena AT, Hakonarson H, Hecht JT, Sangiorgi L, Pacifici M, Enomoto-Iwamoto M, Grant SF: The type 2 diabetes associated rs7903146 T allele within TCF7L2 is significantly under-represented in Hereditary Multiple Exostoses: Insights into pathogenesis. Bone 72: 123-127, 2014.

back to top
Last updated: 11/04/2015
The Trustees of the University of Pennsylvania