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My lab’s primary research goals are directed towards understanding the genetic, cellular, and mechanical mechanisms that regulate normal development, disease, and repair of dense connective tissues. I am particularly interested in identifying markers that define resident progenitors vs. mature cell types and the environmental cues (biochemical and biophysical) that regulate their differentiation. I was awarded a K99/R00 grant in 2015 to define the tendon cell lineage and pathways that regulate tenogenesis, which led to our current work investigating the role of hedgehog signaling in tendon-to-bone repair and developing novel drug delivery systems targeting this pathway to improve repair outcomes. My lab also examines how mechanical forces impact the formation and maintenance of dense connective tissues. Ultimately, the long-term goals of my lab are directed towards translating these mechanistic studies to novel therapeutic strategies.
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Selected Publications
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Leiphart RJ, Eekhoff JD, Weiss SN, Betts R, Carlson JA, Paglia-Garcés PL, Dyment NA, Birk DE, Soslowsky LJ.: Collagen V Influences Homeostatic Maintenance of Patellar Tendon Failure Properties in Mature Female Mice. J Orthop Res Aug 2025.
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He Q, Lu J, Liang Q, Yao L, Sun T, Wang H, Duffy M, Jiang X, Lin Y, Lee JH, Ahn J, Dyment NA, Mourkioti F, Boerckel JD, Qin L.: Prg4+ fibroadipogenic progenitors in muscle are crucial for bone fracture repair. Proc Natl Acad Sci U S A 122: e2417806122, Aug 2025.
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Nijsure MP, Tobin B, Jones DL, Lang A, Hallström G, Baitner M, Tanner GI, Kotsaris G, Moharrer Y, Panebianco CJ, Seidl EG, Dyment NA, Szeto GL, Wood L, Boerckel JD.: YAP regulates transcriptional programs for layer-specific periosteal expansion during fracture repair. Sci Adv 11: eadw0126, Aug 2025.
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Mary Kate Evans, Ngoc Hoang, Tonia Tsinnman, Xi Jiang, Ellie Fergurson, Joel Boerckel, Lin Han, Eiki Koyama, Robert Mauck, Nathaniel Dyment: Non-Muscle Myosin Isoforms Differentially Regulate Deltoid Tuberosity Initiation and Maturation. ASME SB3C Summer Bioengineering Conference June 2025.
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Zhang EY, Blanch TE, Ahmed SB, Jiang X, Dyment NA, Heo SC.: Epigenetic regulation and mechanobiological adaptation in tenocytes during maturation. APL Bioeng 9: 026127, Jun 2025.
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Fujino K, Keith S, Kamalitdinov TB, Madi R, Jiang X, Zgonis MH, Miller LM, Kuntz AF, Dyment NA.: Compressive Graft Fit Promotes Tendon-to-Bone Integration After Anterior Cruciate Ligament Reconstruction. Am J Sports Med Jun 2025.
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Meghan Kupratis, Jiaqi Xiang, Kevin Burt, Yuqi Zhang, Bryan Kwok, Sara Tufa, Douglas Keene, Nathaniel Dyment, Lin Han, Eiki Koyama, Robert Mauck: Emergent Cell Subpopulations and Time-Evolving Biophysical Cues in the Developing Porcine Meniscus. ASME SB3C Summer Bioengineering Conference June 2025.
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Li Y, Tress A, Maye P, Edwards K, Findletar A, Dyment NA, Yamaguchi Y, Rowe DW, Le-Chan G, Chan SSK, Lo KW.: Genetic Deficiency of Hyaluronan Synthase 2 in the Developing Limb Mesenchyme Impairs Postnatal Synovial Joint Formation. Biomedicines 13: 1324, May 2025.
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Usami Y, Jiang X, Dyment NA, Kokubun T.: Limb motility and ambulation as mechanical cues in postnatal murine tendon development. Dev Biol 525: 130-138, May 2025.
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Yuqi Zhang, Meghan E. Kupratis, Giorgos Kotsaris, Nathaniel Dyment, Lin Han, Eiki Koyama, Robert L. Mauck: Altered Transcriptional Landscape And Emergent Region-dependent Mechano-response In The Developing Porcine Meniscus. Orthopaedic Research Society Annual Meeting February 2025.
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Last updated: 10/16/2025
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The Trustees of the University of Pennsylvania
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