Department of Otorhinolaryngology

Otorhinolaryngology
faculty photo

Marcia Simpson Brose, MD PhD

Assistant Professor of Otorhinolaryngology: Head and Neck Surgery at the Hospital of the University of Pennsylvania
Member, University of Pennsylvania Center for Research on Reproduction and Women’s Health
Member, Abramson Cancer Center of the University of Pennsylvania
Member, Clinical Trials Scientific Review and Monitoring Committee
Member, Medical Scientist Training Program Admissions Committee
Director, Head and Neck Clinical Trials, Department of Otorhinolaryngology: Head and Neck Surgery
Director, Thyroid Cancer Therapeutics Program, Department of Otorhinolaryngolgy: Head and Neck Surgery
Member, American Cancer Society, Internal Review Group (ACS IRG)
Vice Chair, Clinical Trials Scientific Review and Monitoring Committee (CTSRMC), Abramson Cancer Center
Member, Department of Otorhinolarynglogy: Head and Neck Cancer Scientist Search Committee
Department: Otorhinolaryngology: Head and Neck Surgery

Contact information
Clinical Research Building (CRB), Room 127

415 Curie Blvd.
Philadelphia, PA 19104
Office: 215-615-6519
Fax: 215-898-2136
Lab: 215-898-0337
Graduate Group Affiliations
Education:
B.A. (Biology)
Amherst College, Amherst, MA, 1986.
Ph.D. (Genetics and Developmental Biology)
Rockefeller University, New York, NY, 1994.
M.D. (Medicine)
Cornell University Medical College, New York, NY, 1995.
Post-Graduate Training
Intern in Internal Medicine, Department of Medicine, Hospital of the University of Pennsylvania, 1995-1996.
Resident in Internal Medicine, Department of Medicine, Hospital of the University of Pennsylvania, 1996-1997.
Fellow in Hematology/Oncology, Department of Medicine, Hospital of the University of Pennsylvania, 1997-2001.
Fellow/Trainee, University of Pennsylvania, Patient Oriented Research Training Program , 1998-1999.
Post-doctoral Research in Cancer Genetics, University of Pennsylvania Cancer Center, Laborartory of Barbara Weber MD, 2001-2004.
Certifications
American Board of Internal Medicine, 1998.
Subspecialty Boards in Oncology, 2003.
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Description of Research Expertise

Dr Brose is the director of the Thyroid Cancer Therapuetics Program and is a global leader in the development of the new field of thyroid cancer oncology. Her Phase II clinical trial of sorafenib in patients with advanced thyroid cancer lead to the successful completion of the first Phase III study, in this disease group (RAI refractory thyroid cancer). She was also one of the top accuers and lead site for the Phase III trial of cabozantinib for advance medullary thyroid cancer, which lead to FDA approval of this agent in November of 2012. Requested to speak and teach worldwide on her expience in the the use of novel agents to treat patients with all types of advanced thyroid cancer (Differentiate, Medullary, and Anaplastic), she is a global leader and educator to physicians and patients alike.

Dr. Brose also runs a lab in the field of tranlsational studies in cancer genetics and genomics. Dr. Brose’s basic science research interest involves the identification of genetic abnormalities in the tumors of patients undergoing targeted therapies. Most of her resarech centers on tranlational projects directly related to samples obtained in the course of her clinical trial program. However, occassionally, science leads to leads in other tumor types. She currently has projects underway in thyroid cancer, breast cancer, lung cancer, colon cancer and esophageal cancer. Once identified, she is interested in understanding if these changes may identify tumors that may have or lack resistance to certain compounds. She has experience in the use of mice, drosophila, human tissue culture and clincial tissue samples. Her analytic tools include all types of PCR, RT-PCR, as well as the use of array comparative genomic hybridization (aCGH) and transcription profiling, taqman analysis, Q-RT-PCR and DNA sequencing on a regular basis, and whole and targeted genome sequencing. She also uses high resolution expression and SNP genotyping tetchnologies (Affymetrix and Illumina) to study the genetic basis of cancer. Dr. Brose provides the key correlative science for ongoing phaseI/II/III clinical trials at the University and internationally.

Description of Clinical Expertise

Treatment of Thyroid Cancer, PhaseI/II/III clinical trials, novel drug target discovery, and use of genetic testing in diagnosis, prognostication and prediction of resopnse to the treatment of cancer. Treatment of Rare Cancers of the Head and Neck.

Description of Other Expertise

Dr. Brose regularly instructs and mentors medical students,Internal Medicine and Head and Neck Surgerical residents, fellows (Hematology/Oncology, and Head and Neck Surgery) and post-doctoral PhD fellows who rotate through her lab in Hematology/Oncology and Cell genetics

Selected Publications

Brose,M.S., Frenette,C.T., Keefe, S.M., Stein, S.M.: Management of Sorafenib-Related Adverse Events: A Clinician’s Perspective. Seminars in Oncology 41(1): S1-S16, February 2014.

Schlumberger, M., Brose, M., Elisei,R., Leboulleux, S., Luster, M., Pitoia, F., Pacini, F.: Definition and management of radioactive iodine-refractory differentiated thyroid cancer (published online ahead of print). Lancet Diabetes and Endocrinology January 2014.

Brose,M.S., Nutting,C.M., Jarzab, B., Elisei, R., Siena, S., Bastholt,L., de la Fouchardiere, C., Pacini, F., Paschke, R., Shong, YK, Sherman, SI, Smit, JWA, Chung, J., Kappeler, C., Pena, C., Molnar, I., Schlumberger, M.J., on behalf of the DECISION Investigators*: Sorafenib in locally advanced or metastatic, radioactive iodine-refractory, differentiated thyroid cancer: a randomized, double-blind, phase III trial. The Lancet in press 2014 Notes: in press.

Brose, Marcia S: Thyroid Cancer Update: Conversations with Oncology Investigators: Bridging the Gap Between Research and Patient Care. Research to Practice. Neil Love MD (eds.). 4(1), October 2013 Notes: CME acredited activity/PODcast Distributed to Practicing Medical Oncologist across the US.

Elisei, R, Schlumberger, MJ., Mueller, S, Schöffski, P, Brose, MS, Shah, MH, Licitra, L, Jarzab, B, Medvedev, V, Kreissl, MC, Niederle, B, Cohen, EW, Wirth, LJ, Ali, H, Hessel, C, Yaron, Y, Ball, D, Nelkin, B, Sherman, SI: Cabozantinib in Progressive Medullary Thyroid Cancer. J Clin Oncol 31(29): 3639-46, October 2013.

Smallridge RC, Copland JA, Brose MS, Wadsworth JT, Houvras Y, Menefee ME, Bible KC, Shah MH, Gramza AW, Klopper JP, Marlow LA, Heckman MG, Von Roemeling R. : Efatutazone, an Oral PPAR-γ Agonist, in Combination with Paclitaxel in Anaplastic Thyroid Cancer: Results of a Multicenter Phase 1 Trial. J Clin Endocrinol Metab 98(6): 2392-400, June 2013.

Lockhart*, A.C., Brose*, M.S., Kim*, E.S., Johnson, D.H., Peppercorn, J.F., Michels, D.L., Storm, C.D., Schuchter, L.M., and Rathmell*, W.K. (*Authors contributed equally to this work) : Physician and Stakeholder Perceptions of Conflict of Interest (COI) Policies in Oncology Journal of Clinical Oncology 31(13): 1677-1682, May (ePub Mar 25th) 2013.

Brose, MS, Nutting, C, Jarzab, B, Elisei, R, Siena, S, Bastholt, L, de la Fouchardiere, C, Pacini, F, Paschke, R, Shong, YK, Sherman, SI, Smit, JWA, Chung, J, Siedentop, H, Molnar, I, Schlumberger, M: Sorafenib in locally advanced or metastatic patients with radioactive iodine-refractory differentiated thyroid cancer: The phase 3 DECISION trial (Plenary Presentation). ASCO Annual Meeting, Abstract #4 May 2013.

Sherman, SI, Cohen, EW, Schöffski, P, Elisei, R, Schlumberger, M, Wirth, L Mangeshkar, M, Aftab, DT, Clary, DO, and Brose M: Efficacy of Cabozantinib (Cabo) in Medullary Thyroid Cancer (MTC) Patients with RAS or RET Mutations: Results from a Phase 3 Study (Oral Presentation). American Society of Clinical Oncololgy Annual Meeting May 2013.

Roth BJ, Krilov L, Adams S, Aghajanian CA, Bach P, Braiteh F, Brose MS, Ellis LM, Erba H, George DJ, Gilbert MR, Jacobson JO, Larsen EC, Lichtman SM, Partridge AH, Patel JD, Quinn DI, Robison LL, von Roenn JH, Samlowski W, Schwartz GK, Vogelzang NJ. : Clinical cancer advances 2012: annual report on progress against cancer from the american society of clinical oncology. J Clin Oncol. (eds.). 31(1): 131-161, January (Epub December 2012) 2013.

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Last updated: 03/05/2014
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