Department of Psychiatry
Penn Behavioral Health

Caryn Lerman

faculty photo

Caryn Lerman

Professor of Psychology in Psychiatry
Mary W. Calkins Professor, Annenberg School for Communication, University of Pennsylvania
Deputy Director, Abramson Cancer Center, University of Pennsylvania
Department: Psychiatry
Graduate Group Affiliations

Contact information
Center for Interdisciplinary Research on Nicotine Addiction (CIRNA)
3535 Market Street, Suite 4100
Philadelphia, PA 19104
Office: 215-746-7141
Fax: 215-746-7140
Education:
B.S. (Psychology)
Pennsylvania State University , 1981.
M.S. (Psychology)
University of Southern California , 1982.
Ph.D. (Clinical Psychology)
University of Southern California , 1984.
(Internship in Clinical/Medical Psychology)
Boston Veterans Administration Medical Center , 1985.
Post-Graduate Training
Intern in Clinical/Medical Psychology, Boston Veterans Administration Medical Center, 1984-1985.
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Description of Research Expertise

Dr. Lerman's research targets the translation of findings in neuroscience, pharmacology, and genetics to improve pharmacotherapy for nicotine dependence; human screening of novel medications for nicotine dependence; and large-scale pharmacogenetic clinical trials for smoking cessation treatment.

Selected Publications

Wang Z, Faith M, Patterson F, Tang K, Kerrin K, Wileyto EP, Detre JA, Lerman C.: Neural substrates of abstinence-induced cigarette cravings in chronic smokers. Journal of Neuroscience 27: 14030-14040, 2007.

Loughead J, Wileyto EP, Valdez NJ, Sanborn P, Tang K, Strasser AA, Ruparel K, Ray R, Gur RC, Lerman C.: Effect of abstinence challenge on brain function and cognition in smokers differs by COMT genotype. Molecular Psychiatry 14(8): 820-826, 2009.

Loughead J, Ray R, Wileyto EP, Ruparel K, Sanborn P, Siegel S, Gur RC, Lerman C.: Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers. Biological Psychiatry 67(8): 715-721, 2010.

Schnoll RA, Patterson F, Wileyto EP, Heitjan D, Shields AE, Asch D, Lerman C. : Effectiveness of extended duration transdermal nicotine therapy: a randomized trial. Annals of Internal Medicine 152(3): 144-151, 2010.

Lerman C, Jepson C, Wileyto EP, Patterson F, Schnoll R, Mroziewicz M, Benowitz N, Tyndale RF.: Genetic variation in nicotine metabolism predicts the efficacy of extended duration transdermal nicotine therapy. Clinical Pharmacology & Therapeutics 87(5): 553-557, 2010.

Ray R, Ruparel K, Newberg A, Wileyto EP, Loughead J, Divgi C, Blendy JA, Logan J, Zubieta JK, Lerman C. : Human mu opioid receptor (OPRM1 A118G) polymorphism is associated with brain mu opiod receptor binding potential in smokers. Proceedings of the National Academy of Sciences USA 108(22): 9268-9273, 2011.

Mrazek DA, Lerman C. : Pharmacogenomics: facilitating clinical implementation. Journal of the American Medical Association 306(3): 304-305, 2011.

Perkins KA, Lerman C. : Early human screening of medications to treat drug addiction: novel paradigms and the relevance of pharmacogenetics. Clinical Pharmacology and Therapeutics 89(3), 2011.

Gold AB, Wileyto EP, Lori A, Conti D, Cubells JF, Lerman C. : Pharmacogenetic association of the Galanin Receptor (GALR1) SNP rs2717162 with smoking cessation. Neuropsychopharmacology 37(7): 1683-1688, 2012.

Falcone M, Gold A, Wileyto EP, Ray R, Ruparel K, Newberg A, Dubroff J, Logan J, Zubieta J-K, Blendy J, Lerman C.: µ-opioid receptor availability in the amygdala is associated with smoking for negative affect relief. Psychopharmacology 222(4): 701-708, 2012.

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Last updated: 10/01/2013
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