Sangwon F Kim
Center for Neurobiology and Behavior
Department of Psychiatry, Perelman School of Medicine
University of Pennsylvania
Philadelphia, PA 19104
Iowa State University, Ames, IA, 1996.
PhD (Experimental Medicine)
McGill University, Montreal, Canada, 2001.
Postdoctoral Fellow, Department of Physiology, McGill University, Montreal, Canada, 2001-2002.
Postdoctoral Fellow, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 2002-2008.
Description of Research ExpertiseSangwon Kim, PhD is a member of the Center for Neurobiology and Behavior in the department of Psychiatry and his laboratory is located in the Translational Research Laboratories.
Research Interest/Key words;
Neurobiology of obesity, Diabetes and Metabolic syndromes
Oxidative stress and neurodegeneration, Metal in the brain, Aging
Neural Circuit, Behavior
There are various exciting projects that I would be happy to discuss in person.
Please check out the lab website for the most updated research interest.
Selected PublicationsChen, Y., Bang, S., Shi, H., Park, S., Kim, S.F.: Acyl-CoA Binding Domain Containing 3 Modulates NAD+ Metabolism through Activating Poly(ADP-ribose) Polymerase 1.; Lipid pathway modulates PARP1. Biochemical Journal 469(2): 189-198, May 2015.
Chen, Y., Mathias, L., Falero-Perez, JM., and Kim, SF.: PKA-mediated phosphorylation of Dexras1 suppresses iron trafficking by inhibiting S-nitrosylation. Federation of European Biochemical Societies (FEBS) Letters In Press 2015.
Carlson, GC., Lin, RE., Chen, Y., Brookshire, BR., White, RS., Lucki, I., Siegel, SJ., and Kim, SF.: Dexras1 a unique ras-GTPase interacts with NMDA receptor activity and provides a novel disassociation between anxiety, working memory and sensory gating. Neuroscience In Press 2015.
Yarchoan, M., Talbot, K., Toledo, JB., Lee, EB., Arvanitakis, Z., Kazi, H., Han, LY., Lee, V.M-Y., Kim, SF., Trojanowski, J., and Arnold, SE: Abnormal serine phosphorylation of insulin receptor substrate-1 is associated with tau pathology in Alzheimer's disease and tauopathies. Acta Neuropathologica 128(5): 679-689, November 2014.
White, RS., Bhattacharya, A., Chen, Y., Carlson, GC, and Kim, SF.: Robust and novel modulation of synaptic excitability in the hippocampus via endogenous free iron. Society for Neuroscience, Washington, DC November 2014 Notes: Poster Presentation.
Bhattacharya, A., Carlson, GC., and Kim, SF.: Intracellular neuronal iron plays a crucial role regulating NMDA excitability in area CA1 of the hippocampus. American Physician Scientists Association North East Regional Meeting, Philadelphia, PA November 2014 Notes: Poster Presentation.
Jochems, J., Teegarden, SL., Chen, Y., Boulden, J., Challis, C., Ben-Dor, GA., Kim, SF., Berton, O.: Enhancement of Stress Resilience Through Histone Deacetylase 6-Mediated Regulation of Glucocorticoid Receptor Chaperone Dynamics. Biological Psychiatry(14), August 2014 Notes: (In Press. epublication ahead of print).
Bhattacharya, A., Carlson, GC., and Kim, SF: Evidence for endogenous iron modulation of NMDA receptor dependent excitability in area CA1 of the hippocampus. The American Medical Student Association National Convention, New Orleans, LA March 2014 Notes: Poster Presentation.
Arnold, SE., Lucki, I., Brookshire, BR., Carlson, GC., Browne, CA., Kazi, H., Bang, S., Choi, BR., Chen, Y., McMullen, MF., and Kim, SF: High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice. Neurobiology of Disease 67: 79-87, 2014.
Bang, S., Chen, Y., Ahima, RS., Kim, SF.: Convergence of IPMK and LKB1/AMPK signaling pathways on metformin action. Molecular Endocrinology 28(7): 1186-1193, 2014.