Anatomical and molecular analyses of mammalian neuronal systems, quantitative microscopy, postmortem immunohistochemical and biochemical studies, insulin signaling in Alzheimer disease, dysbindin abnormalities in schizophrenia, and correlative molecular and behavioral studies on animal models of genetic factors in schizophrenia.
Selected Publications
Fairless, A.H., Dow, H.C., Toledo, M.M., Malkus, K.A., Edelmann, M., Talbot, K., Arnold, S.E., and Brodkin, E.S.: Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain. Brain Research 1230: 211-217, September 2008.
Talbot, K., Cho, D.-S., Ong, W.-Y., Benson, M.A., Han, L.-Y., Kazi, H.A., Hahn, C.-G., Blake, D.J., and Arnold, S.E.: Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin. Human Molecular Genetics 15(20): 3041-3054, October 2006.
Hahn, C.-G., Wang, H.-Y., Cho, D.-S., Talbot, K., Gur, R.E., Berrettini, W.H., Bakshi, K., Kamins, J., Borgmann-Winter, K.E., Siegel, S.J., and Arnold, S.E.: Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nature Medicine 12(7): 824-828, June 2006.
Arnold, S.E., Talbot, K., and Hahn, C.-G: Neurodevelopment, neuroplasticity, and new genes for schizophrenia. Progress in Brain Research 147: 319-345, April 2005.
Talbot, K., Eidem, W., Tinsley, C.L., Benson, M.A., Thompson, E.W., Smith, R.J., Hahn, C.-G., Siegel, S.J., Trojanowski, J.Q., Gur, R.E., Blake, D.J., and Arnold, S.E.: Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. Journal of Clinical Investigation 113(9): 1353-1363, March 2004.
Uryu, K., Giasson, B.I., Longhi, L., Martinez, D., Murray, I., Conte, V., Nakamura, M., Saatman, K., Talbot, K., Horiguchi, T., McIntosh, T., Lee, V. M.-Y., and Trojanowski, J.Q.: Age dependent synuclein pathology following traumatic brain injury in mice. Experimental Neurology 184(1): 214-224, November 2003.
Talbot, K. and Arnold, S.A.: The parahippocampal region in schizophrenia. The Parahippocampal Region, Organization and Role in Cognitive Function. M. Witter and F. Wouterlood (eds.). Oxford University Press, Page: 297-320, November 2002 Notes: Book chapter.
Talbot, K. Young, R.A., Jolly-Tornetta, C., Lee, V. M.-Y., Trojanowski, J.Q., and Wolf, B.A. : A frontal variant of Alzheimer’s disease exhibits decreased calcium-independent phospholipase A2 activity in the prefrontal cortex. Neurochemistry International 37(1): 17-31, July 2000.
Young, R.A., Talbot, K., Gao, Z.-Y., Trojanowski, J.Q., and Wolf, B.A. : Phospholipase pathway in Alzheimer’s disease brains: decrease in Gαi in dorsolateral prefrontal cortex. Molecular Brain Research 66(1-2): 188-190, March 1999.
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Last updated: 09/04/2008
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