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Rahim R. Rizi, Ph.D.

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Professor of Radiology
Department: Radiology

Contact information
Department of Radiology
1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104-6100
Office: 215-573-0891
Fax: 215-349-5115
Graduate Group Affiliations
B.S. (Chemistry)
University of Isfahan, Iran, 1976.
M.S. (Physical Chemistry)
Western Illinois University, 1978.
Ph.D. (Physical Chemistry)
University of Iowa , 1983.
M.S. (Computer Science)
University of Pennsylvania , 1987.
Post-Graduate Training
Postdoctoral Fellow, Radiology, University of Penn School of Medicine, 1994-1998.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

The primary mission of the Functional and Metabolic Imaging Group (FMIG) is the development and application of novel hyperpolarized MRI techniques to the diagnosis of various pulmonary and metabolic disorders. Hyperpolarization, the process of drastically increasing the population difference between nuclear spin states, provides a platform for imaging lung physiology and metabolic activity with spatial and temporal resolution unattainable with conventional MRI techniques, thus offering the potential for the earlier diagnosis of disease states and the precise monitoring of a patient’s response to medical treatment. This core research theme is executed with an eye toward several ultimate goals: the identification of changes in pulmonary structure and function associated with disease, a more complete understanding of pathogenesis, and the establishment of a more sensitive testing environment to develop treatments for lung disease. To date, significant contributions in these areas include new imagining techniques for the comprehensive description of lung physiology and structure, accurate imaging of the regional pulmonary partial pressure of oxygen in both humans and large and small animals, highly developed imaging of regional ventilation, and a state-of-the-art mechanical ventilation device. Specifically, our research activities at FMIG is divided into four general branches: 1) The development of novel imaging techniques for the quantitative assessment of pulmonary structure and function: 2)The development of novel methods for real-time metabolic imaging: 3)The construction of novel polarization apparatuses: 4) The development and implementation of rapid imaging pulse sequences.

Selected Publications

Drachman Nicholas, Kadlecek Stephen, Pourfathi Mehrdad, Xin Yi, Profka Harilla, Rizi Rahim: In vivo pH mapping of injured lungs using hyperpolarized [1-(13) C]pyruvate. Magnetic resonance in medicine Oct 2016.

Hamedani Hooman, Kadlecek Stephen, Xin Yi, Siddiqui Sarmad, Gatens Heather, Naji Joseph, Ishii Masaru, Cereda Maurizio, Rossman Milton, Rizi Rahim: A hybrid multibreath wash-in wash-out lung function quantification scheme in human subjects using hyperpolarized (3) He MRI for simultaneous assessment of specific ventilation, alveolar oxygen tension, oxygen uptake, and air trapping. Magnetic resonance in medicine Oct 2016.

Siddiqui Sarmad, Kadlecek Stephen, Pourfathi Mehrdad, Xin Yi, Mannherz William, Hamedani Hooman, Drachman Nicholas, Ruppert Kai, Clapp Justin, Rizi Rahim: The use of hyperpolarized carbon-13 magnetic resonance for molecular imaging. Advanced drug delivery reviews Sep 2016.

Xu He N, Kadlececk Stephen, Shaghaghi Hoora, Zhao Huaqing, Profka Harilla, Pourfathi Mehrdad, Rizi Rahim, Li Lin Z: Differentiating inflamed and normal lungs by the apparent reaction rate constants of lactate dehydrogenase probed by hyperpolarized (13)C labeled pyruvate. Quantitative imaging in medicine and surgery 6(1): 57-66, Feb 2016.

Hamedani Hooman, Clapp Justin T, Kadlecek Stephen J, Emami Kiarash, Ishii Masaru, Gefter Warren B, Xin Yi, Cereda Maurizio, Shaghaghi Hoora, Siddiqui Sarmad, Rossman Milton D, Rizi Rahim R: Regional Fractional Ventilation by Using Multibreath Wash-in (3)He MR Imaging. Radiology 279(3): 150495, Jan 2016.

Cereda Maurizio, Xin Yi, Hamedani Hooman, Clapp Justin, Kadlecek Stephen, Meeder Natalie, Zeng Johnathan, Profka Harrilla, Kavanagh Brian P, Rizi Rahim R: Mild Loss of Lung Aeration Augments Stretch in Healthy Lung Regions. Journal of applied physiology (Bethesda, Md. : 1985) 120(4): jap.00734.2015, Dec 2015.

Cereda Maurizio, Xin Yi, Meeder Natalie, Zeng Johnathan, Jiang YunQing, Hamedani Hooman, Profka Harrilla, Kadlecek Stephen, Clapp Justin, Deshpande Charuhas G, Wu Jue, Gee James C, Kavanagh Brian P, Rizi Rahim R: Visualizing the Propagation of Acute Lung Injury. Anesthesiology 124(1): 121-31, Nov 2015.

Clapp Justin, Hamedani Hooman, Kadlecek Stephen, Xin Yi, Shaghaghi Hoora, Siddiqui Sarmad, Rossman Milton D, Rizi Rahim R: Multibreath alveolar oxygen tension imaging. Magnetic resonance in medicine 76(4): 1092-101, Oct 2015.

Pourfathi Mehrdad, Clapp Justin, Kadlecek Stephen J, Keenan Caroline D, Ghosh Rajat K, Kuzma Nicholas N, Rizi Rahim R: Low-temperature dynamic nuclear polarization of gases in Frozen mixtures. Magnetic resonance in medicine 76(3): 1007-14, Oct 2015.

Shaghaghi Hoora, Kadlecek Stephen, Siddiqui Sarmad, Pourfathi Mehrdad, Hamedani Hooman, Clapp Justin, Profka Harrilla, Rizi Rahim: Ascorbic acid prolongs the viability and stability of isolated perfused lungs: A mechanistic study using (31)P and hyperpolarized (13)C NMR. Free radical biology & medicine 89: 62-71, Jul 2015.

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Last updated: 10/18/2016
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