Department of Radiology | Penn Medicine

Faculty & Staff

Felix Werner Wehrli, Ph.D.

Professor of Radiology

Director, Laboratory for Structural NMR Imaging

Department: Radiology

Contact information

University of Pennsylvania
Department of Radiology
1 Founders Pavilion
MRI Education Center
3400 Spruce Street
Philadelphia, PA 19104

Office: (215) 662-7951
Fax: (215) 662-7263

Email:
wehrli@mail.med.upenn.edu

Graduate Group Affiliations

Biochemistry and Molecular Biophysics

Publications

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Links
Search PubMed for articles
Department of Radiology, Laboratory for Structural NMR Imaging
BMB Graduate Group

Education:
M.S. (Chemistry)
Swiss Federal Institute of Technology , 1967.
Ph.D. (Chemistry)
Swiss Federal Institute of Technology, 1970.

Permanent link

> School of Medicine > Faculty > Details

Description of Research Expertise

Research of the Laboratory is aimed at quantitatively characterizing tissue microarchitecture and its relationship to physiology and function by means of spatially resolved nuclear magnetic resonance in animals and humans. The current focus of the Laboratory is on the development of new methods for the quantitative assessment of metabolic bone disease by means of the MR-based "virtual bone biopsy", and new methods for the study of tissue mineralization. A second line of research focuses on the quantification of carotid artery disease and its implications on brain perfusion. Additional projects deal with ultrahigh-resolution microscopy of neuronal architecture in spinal cord injury models as well as methods for indirect assessment of tissue microstructure by means of diffusion diffraction, anisotropic dipolar relaxation and multiple quantum coherence imaging.

Selected Publications

Rajapakse CS, Magland J, Zhang XH, Liu XS, Wehrli SL, Guo XE, Wehrli FW: Implications of noise and resolution on mechanical properties of trabecular bone estimated by image-based finite-element analysis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society Mar 2009.

Langham Michael C, Magland Jeremy F, Epstein Charles L, Floyd Thomas F, Wehrli Felix W: Accuracy and precision of MR blood oximetry based on the long paramagnetic cylinder approximation of large vessels. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 62(2): 333-40, Aug 2009.

Techawiboonwong Aranee, Song Hee Kwon, Leonard Mary B, Wehrli Felix W: Cortical bone water: in vivo quantification with ultrashort echo-time MR imaging. Radiology 248(3): 824-33, Sep 2008.

Magland Jeremy F, Wehrli Felix W: Trabecular bone structure analysis in the limited spatial resolution regime of in vivo MRI. Academic radiology 15(12): 1482-93, Dec 2008.

Wehrli Felix W, Ladinsky Glenn A, Jones Catherine, Benito Maria, Magland Jeremy, Vasilic Branimir, Popescu Andra M, Zemel Babette, Cucchiara Andrew J, Wright Alexander C, Song Hee K, Saha Punam K, Peachey Helen, Snyder Peter J: In vivo magnetic resonance detects rapid remodeling changes in the topology of the trabecular bone network after menopause and the protective effect of estradiol. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 23(5): 730-40, May 2008.

Anumula S, Magland J, Wehrli S L, Ong H, Song H K, Wehrli F W: Multi-modality study of the compositional and mechanical implications of hypomineralization in a rabbit model of osteomalacia. Bone 42(2): 405-13, Feb 2008.

Jones CE., Wolf RL., Detre JA., Das B., Saha PK., Wang J., Zhang Y., Song HK., Wright AC., Mohler EM 3rd., Fairman RM., Zager EL., Velazquez OC., Golden MA., Carpenter JP., Wehrli FW.: Structural MRI of carotid artery atherosclerotic lesion burden and characterization of hemispheric cerebral blood flow before and after carotid endarterectomy. NMR in Biomedicine 19(2): 198-208, Apr 2006.

Fernandez-Seara MA., Techawiboonwong A., Detre JA., Wehrli FW.: MR susceptometry for measuring global brain oxygen extraction. Magnetic Resonance in Medicine 55(5): 967-73, May 2006.

Wehrli FW., Fernandez-Seara MA.: Nuclear magnetic resonance studies of bone water. [Review] [49 refs] Annals of Biomedical Engineering 33(1): 79-86, Jan 2005.

Benito M. Vasilic B. Wehrli FW. Bunker B. Wald M. Gomberg B. Wright AC. Zemel B. Cucchiara A. Snyder PJ.: Effect of testosterone replacement on trabecular architecture in hypogonadal men. Journal of Bone & Mineral Research. 20(10): 1787-91, October 2005.

Saha PK., Wehrli FW.: Measurement of trabecular bone thickness in the limited resolution regime of in vivo MRI by fuzzy distance transform. IEEE Transactions on Medical Imaging 23(1): 53-62, Jan 2004.

Fernandez-Seara MA. Wehrli SL. Wehrli FW. : Multipoint mapping for imaging of semi-solid materials. Journal of Magnetic Resonance. 160(2): 144-50, February 2003.

Fernandez-Seara MA., Wehrli SL., Wehrli FW.: Diffusion of exchangeable water in cortical bone studied by nuclear magnetic resonance. Biophysical Journal 82(1 Pt 1): 522-9, Jan 2002.

Wehrli FW., Gomberg BR., Saha PK., Song HK., Hwang SN., Snyder PJ.: Digital topological analysis of in vivo magnetic resonance microimages of trabecular bone reveals structural implications of osteoporosis. Journal of Bone & Mineral Research 16(8): 1520-31, Aug 2001.