Faculty & Staff

Gang Zheng, Ph.D.

faculty photo
Adjunct Professor of Radiology
Department: Radiology

Contact information
University of Toronto
Toronto Medical Discovery Tower
5th Flr. Rm. 363
101 College Street
Toronto, Ontario, M5G 1L7
Office: 416-581-7668
Fax: 416-581-7667
Education:
B.S. (Chemistry)
Hangzhou University, 1988.
M.S. (Organic Chemistry)
Hampton University , 1995.
Ph.D. (Medicinal Chemistry)
State University of New York at Buffalo, 1999.
Post-Graduate Training
Postdoctoral Fellow, Photogynamic Therapy , Roswell Park Cancer Institute, Photogynamic Therapy Center, Buffalo, New York, 1999-2000.
Research Associate, Radiology, University of Pennsylvania, Department of Radiology, Philadelphia, PA, 2000-2001.
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Description of Research Expertise

1) Molecular Imaging Chemistry
a) Novel targeting strategy of contrast agents (optical, MRI and MRS) for cancer detection
b) Novel activation strategy of photodynamic therapy agents
c) Novel Delivery strategy using multifunctional lipoproptein-based nanoplatform (LBNP)
2) Porphyrin Chemistry

Selected Publications

Li H, Marotta D, Kim SK, Busch TM, Wileyto EP, Zheng G*: High Payload Delivery of Optical Imaging and Photodynamic Therapy Agents to Tumors Using Phthalocyanine-Reconstituted LDL Nanoparticles. J. Biomed. Optics 2005 Notes: * Corresponding author.

Zheng G, Li H, Marotta D, Kim S, Sunar U, Glickson J: Supersized low-density lipoprotein nanoparticles for high payload and target-specific delivery of contrast agents. Mole. Imaging and Biol. 7: 109, 2005.

Wu SP, Lee I, Ghoroghchian PP, Frail PR, Zheng G, Glickson JD, Therien MJ: Near-Infrared Optical Imaging of B16 Melanoma Cells via Low-Density Lipoprotein-Mediated Uptake and Delivery of High Emission Dipole Strength Tris[(porphinato)zinc(II)] Fluorophores. Bioconjugate Chem. 16: 542-550, 2005.

Zheng G, Chen J, Stefflova K, Niedre M, Wilson B: Near-infrared fluorescence imaging guided therapy: molecular beacon-based photosensitizers triggered by c-raf-1 mRNA. Proceedings of Era of Hope Department of Defense Breast Cancer Research Program Meeting June 2005.

Zheng G, Chen J, Li H, Glickson JD: Redirecting Lipoproteins to Selected Alternate Receptors: A Biocompatible Nanoplatform for Targeted Delivery of Diverse Imaging and Therapeutic Agents 4th Annaul Meeting of the Society for the Molecular Imaging 2005.

Stefflova K, Chen J, Li H, Marotta D, Zheng G: Targeted PDT Agent with Built-in Apoptosis Reporter Designed for Assessing Therapeutic Outcome In Vivo 4th Annual Meeting of the Society for the Molecular Imaging 2005.

Zheng G*, Chen J, Li H, Glickson JD: Rerouting Conjugated Lipoproteins to Selected Alternate Receptors: A Biocompatible Nanoplatform for Delivery of Diverse Diagnostic and Therapeutic Agents Proc. Natl. Acad. Sci. USA Page: Accepted, 2005 Notes: Corresponding author.

Li H, Zhang ZH, Blessington D, Nelson DS, Zhou R, Lund-Katz, S, Chance B, Glickson JD and Zheng G*: Optical Imaging of Tumors Using Carbocyanine Labeled LDL. Acad. Rad. 11: 669-677, 2004 Notes: * Corresponding author.

Zhang ZH, Blessington D, Busch TM, Glickson JD, Luo QM, Chance B and Zheng G* : Redox ratio of mitochondria as an indicator for the response of Photodynamic Therapy. J. Biomed. Optics 9: 772-778, 2004 Notes: * Corresponding author.

Zhang ZH, Li H, Liu Q, Zhou LL, Zhang M, Luo QM, Glickson JD, Chance B and Zheng G*: Metabolic Imaging of Tumors Using Intrinsic and Extrinsic Fluorescent Markers. Biosensors and Bioelectronics 20: 643-650, 2004 Notes: * Corresponding author.

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Last updated: 08/15/2013
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