Dr. Song is a biomedical engineer with a strong background in MRI physics and expertise in various areas of MRI engineering. Dr. Song has extensive experience in developing novel dynamic imaging strategies in MRI. For over a decade, his research has focused on the development of dynamic contrast-enhanced (DCE-) MRI strategies based on novel radial data acquisition and reconstruction methods that allow ultra-rapid dynamic imaging at both high spatial and high temporal resolutions. Utilizing the golden angle radial acquisition strategy, Dr. Song also developed and implemented effective strategies to retrospectively compensate for respiratory motion in DCE-MRI. The technique also permits the reconstruction of the dynamic series to be highly flexible, allowing many of the decisions regarding spatial/temporal resolution to be made retrospectively and optimally. These strategies are currently being utilized for the assessment of treatment effects in various tumors, including lung, liver, breast, kidney and ovarian/fallopian tube. The methods he has developed have also been utilized in other areas of research, including rapid non-contrast enhanced dynamic MRA and fast tissue T1 mapping. Dr. Song collaborates with clinicians in various departments within Penn’s School of Medicine and other institutions, including the Departments of Medicine, Obstetrics and Gynecology, Neurology, and Radiation Oncology. The scope of training under Dr. Song’s guidance includes understanding the various tumor perfusion models, MRI physics, MRI pulse sequence programming and image post-processing.
Zhang Ning, Magland Jeremy F, Song Hee Kwon, Wehrli Felix W: Registration-based autofocusing technique for automatic correction of motion artifacts in time-series studies of high-resolution bone MRI. Journal of magnetic resonance imaging : JMRI 41(4): 954-63, Apr 2015.
Wang Ping, Xue Yiqun, Zhao Xia, Yu Jiangsheng, Rosen Mark, Song Hee Kwon: Effects of flip angle uncertainty and noise on the accuracy of DCE-MRI metrics: comparison between standard concentration-based and signal difference methods. Magnetic resonance imaging 33(1): 166-73, Jan 2015.
Song Hee Kwon, Yan Lirong, Smith Robert X, Xue Yiqun, Rapacchi Stanislas, Srinivasan Subashini, Ennis Daniel B, Hu Peng, Pouratian Nader, Wang Danny J J: Noncontrast enhanced four-dimensional dynamic MRA with golden angle radial acquisition and K-space weighted image contrast (KWIC) reconstruction. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 72(6): 1541-51, Dec 2014.
Ciunci Christine A, Perini Rodolfo F, Avadhani Anjali N, Kang Hyunseon C, Sun Weijing, Redlinger Maryann, Harlacker Kathleen, Flaherty Keith T, Giantonio Bruce J, Rosen Mark A, Divgi Chaitanya R, Song Hee Kwon, Englander Sarah, Troxel Andrea, Schnall Mitchell, O'Dwyer Peter J: Phase 1 and pharmacodynamic trial of everolimus in combination with cetuximab in patients with advanced cancer. Cancer 120(1): 77-85, Jan 2014.
Li Cheng, Magland Jeremy F, Rad Hamidreza Saligheh, Song Hee Kwon, Wehrli Felix W: Comparison of optimized soft-tissue suppression schemes for ultrashort echo time MRI. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 68(3): 680-9, Sep 2012.
Xue Yiqun, Yu Jiangsheng, Kang Hyun Seon, Englander Sarah, Rosen Mark A, Song Hee Kwon: Automatic coil selection for streak artifact reduction in radial MRI. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 67(2): 470-6, Feb 2012.
Bhagat Yusuf A, Rajapakse Chamith S, Magland Jeremy F, Wald Michael J, Song Hee Kwon, Leonard Mary B, Wehrli Felix W: On the significance of motion degradation in high-resolution 3D μMRI of trabecular bone. Academic radiology 18(10): 1205-16, Oct 2011.
Rad Hamidreza Saligheh, Lam Shing Chun Benny, Magland Jeremy F, Ong Henry, Li Cheng, Song Hee Kwon, Love James, Wehrli Felix W: Quantifying cortical bone water in vivo by three-dimensional ultra-short echo-time MRI. NMR in biomedicine 24(7): 855-64, Aug 2011.
Yu Jiangsheng, Xue Yiqun, Song Hee Kwon: Comparison of lung T2* during free-breathing at 1.5 T and 3.0 T with ultrashort echo time imaging. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 66(1): 248-54, Jul 2011.
Wright Alexander C, Lemdiasov Rostislav, Connick Thomas J, Bhagat Yusuf A, Magland Jeremy F, Song Hee Kwon, Toddes Steven P, Ludwig Reinhold, Wehrli Felix W: Helmholtz-pair transmit coil with integrated receive array for high-resolution MRI of trabecular bone in the distal tibia at 7T. Journal of magnetic resonance (San Diego, Calif. : 1997) 210(1): 113-22, May 2011.
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Last updated: 05/14/2015
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