Research Interest Summary:
The main interest of this group is the non invasive detection of metabolic changes that occur during tumor development and in response to anticancer drugs in models of human breast cancer. We employ a number of imaging modalities that include near infrared fluorescence optical imaging, MRI and MRS, PET and Cerenkov imaging. We have an active program in the design, synthesis and characterization of NIR optical contrast agents for the detection of phospholipase and choline kinase expression and activity in tumors and for the detection of pH and redox changes in the tumor microenvironment. Changes in lipid metabolite levels are monitored using MRS to determine potential biochemical markers for the detection of tumors and their early response to therapy and correlated with near-infrared optical imaging using enzyme-activated fluorescent contrast agents to detect enzyme activity in situ. We are pioneering the development of Cerenkov imaging by creating novel radiolabeled probes suitable for determining both location and function using dual PET and optical imaging.
MR spectroscopy, MR imaging, NIR optical imaging, Cerenkov imaging, contrast agent design, anticancer drugs, lipid metabolism, cancer pharmacology
Kalogiannis, M., Delikatny, E.J. and Jeitner, T.M.: Serotonin as a putative scavenger of hypohalous acid in the brain. Biochimica Biophysica Acta - Molecular Basis of Disease 1862(4): 651-661, Apr 2016.
Karunamuni, R., Naha, P.C., Lau, K.C., Al-Zaki, A., Popov, A.V., Delikatny, E.J., Tsourkas, A.T., Cormode, D.A., and Maidment, A.D.A.: Development of silica-encapsulated silver nanoparticles as contrast agents intended for dual-energy mammography. European Radiology in press 2016 Notes: DOI 10.1007/s00330-015-4152-y.
Chiorazzo, M.G., Bloch, N.B., Popov, A.V. and Delikatny, E.J.: Synthesis and evaluation of cytosolic phospholipase A2 activatable fluorophores for cancer imaging. Bioconjugate Chemistry 26(12): 2360-2370, Dec 2015 Notes: DOI: 10.1021/acs.bioconjchem.5b00417.
Judy, R.P., Keating, J.J., DeJesus, E.M., Jiang, J.X., Okusanya, O.T., Nie, S., Holt, D.E., Arlauckas, S.P., Low, P.S., Delikatny, E.J. and Singhal, S.: Quantification of tumor fluorescence during intraoperative optical cancer imaging. Scientific Reports 5: 16208, Nov 2015.
Kachur, A.V., Arroyo, A.D., Popov, A.V., Saylor, S.J. and Delikatny, E.J.: Synthesis of F-18 labeled resazurin by direct electrophilic fluorination Journal of Fluorine Chemistry 178: 136-141, Oct 2015.
Gao, Q., Yan, L., Chiorazzo, M., Delikatny, E.J., Tsourkas, A. and Cheng, Z.: PLA2-responsive and SPIO-loaded phospholipid micelles. Chemical Communications 51(61): 12313-12315, Aug 2015.
Jeitner, T.M., Kalogiannis, M., Patrick, P.A., Gomolin, I., Palaia, T., Ragolia, L., Brand, D. and Delikatny, E.J.: Inflaming the diseased brain: A role for tainted melanins. Biochimica Biophysica Acta - Molecular Basis of Disease 1852(5): 937-950, May 2015.
Kumar, M., Arlauckas, S.P., Saksena, S., Verma, G., Ittyerah, R., Pickup, S., Popov, A.V., Delikatny, E.J. and Poptani, H.: Magnetic resonance spectroscopy for detection of choline kinase inhibition in the treatment of brain tumors. Molecular Cancer Therapeutics 14(4): 899-908, Apr 2015.
Czupryna, J., Kachur, A.V., Blankemeyer, E., Popov A.V., Arroyo, A.D., Karp, J.S. and Delikatny, E.J.: Cerenkov-specific contrast agents for detection of pH in vivo. Journal of Nuclear Medicine 56(3): 483-488, Mar 2015.
Verma, G., Hariharan, H., Nagarajan, R., Nanga, R.P., Delikatny, E.J., Thomas, M.A. and Poptani, H.: Implementation of 2D L-COSY at 7T: An investigation of reproducibility in human brain. Journal of Magnetic Resonance Imaging 40(6): 1319-27, Dec 2014.
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Last updated: 08/26/2016
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