Faculty & Staff

Ravinder Reddy, PhD

faculty photo
Professor of Radiology
Department: Radiology

Contact information
B1 Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104-6100
Office: (215) 898-5708
Fax: (215) 573-2113
Lab: (215) 898-9357
Graduate Group Affiliations
Education:
B.Sc. (Math, Physics, and Chemistry)
Osmania University , 1979.
M.Sc. (Chemistry)
Kakatiya University , 1982.
Ph.D. (Chemistry)
Indian Institute of Technology, 1989.
Post-Graduate Training
Research Assistant, Indian Institute of Technology, 1988-1989.
Post Doctoral Fellow, University of Pennsylvania, 1989-1991.
Research Associate, University of Pennsylvania, 1991-1993.
Certifications
German Language Proficiency Certificate, .
Hindi Visharada Certificate , .
Permanent link
 
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Description of Research Expertise

My research interests are in developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for the early diagnosis and quantification of physiological and functional aberrations in pathologies such as arthritis, stroke, cancer and Alzheimer’s disease. Our pulse sequence developmental approaches exploit quadrupolar spin-dynamics, polarization transfer, multiple quantum coherences, indirect detection via chemical exchange and spin-locking T1ρ MRI for studying molecular dynamics in biological tissues in vivo.

Specifically, T1ρ and Sodium MRI techniques are designed to map proteoglycan molecules (e.g. aggrecan) in cartilage as a biomarker for early arthritis in vivo. T1ρ MRI is also targeted to impart novel contrast in various tissue types (brain, connective tissues and tumors), and to detect metabolically produced H217O for studying cerebral blood flow and cerebral oxidative metabolism.

Recent developmental work on chemical exchange saturation transfer (CEST) based MRI methods is focused on measuring endogenous but low concentration metabolites in the brain, such as glutamate, myoinositol and creatine to address central nervous system disorders. In addition, a creatine CEST method is currently being explored to measure high-energy phosphate metabolism in the myocardium in heart disease.

- See more at: http://cmroi.med.upenn.edu/personnel/ravinder-reddy-ph-d/#sthash.qFNreUgo.dpuf

Selected Publications

Cai K, Singh A, Poptani H, Li W, Yang S, Lu Y, Hariharan H, Zhou XJ, Reddy R. : CEST signal at 2ppm (CEST@2ppm) from Z-spectral fitting correlates with creatine distribution in brain tumor. NMR Biomed. 28((1)): 1, Jan 2015.

Crescenzi R, DeBrosse C, Nanga RP, Reddy S, Haris M, Hariharan H, Iba M, Lee VM, Detre JA, Borthakur A, Reddy R: In vivo measurement of glutamate loss is associated with synapse loss in a mouse model of tauopathy. Neuroimage 101: 185, Nov 2014.

Cai K, Xu HN, Singh A, Moon L, Haris M, Reddy R, Li L.: Breast Cancer Redox Heterogeneity Detectable with Chemical Exchange Saturation Transfer (CEST) MRI. Mol Imaging Biol 16(5): 670, Oct 2014.

Kogan F, Haris M, Debrosse C, Singh A, Nanga RP, Cai K, Hariharan H, Reddy R.: In vivo chemical exchange saturation transfer imaging of creatine (CrCEST) in skeletal muscle at 3T. J Magn Reson Imaging 40(3): 596, Sep 2014.

Haris M, Singh A, Mohammed I, Ittyerah R, Nath K, Nanga RP, Debrosse C, Kogan F, Cai K, Poptani H, Reddy D, Hariharan H, Reddy R: In vivo magnetic resonance imaging of tumor protease activity. Sci Rep 4: 6081, Aug 2014.

Haris M, Singh A, Cai K, Nath K, Verma G, Nanga RP, Hariharan H, Detre JA, Epperson N, Reddy R: High resolution mapping of modafinil induced changes in glutamate level in rat brain. PLoS One 9(7): e103154, Jul 2014.

Nanga RP, DeBrosse C, Singh A, D'Aquilla K, Hariharan H, Reddy R: Glutaminase catalyzes reaction of glutamate to GABA. Biochem Biophys Res Commun 448(4): 361, Jun 2014.

Singh A, Haris M, Cai K, Kogan F, Hariharan H, Reddy R: High Resolution T1ρ Mapping of In Vivo Human Knee Cartilage at 7T. PLOS ONE 9(5): e97486, May 2014.

Haris M, Singh A, Cai K, Kogan F, McGarvey J, DeBrosse C, Zsido GA, Walter RT Witschey WRT, Koomalsingh K, Pilla JJ, Chirinos JA, Ferrari VA, Gorman JH, Hariharan H, Robert Gorman RC, Reddy R. : A Technique for In Vivo Mapping of Myocardial Creatine Kinase Metabolism. Nature Medicine 20(2): 209, Feb 2014.

Cai K, Singh A, Rolf D, Nanga RP, Haris M, Hariharan H, Gur R, Reddy R.: Mapping glutamate in subcortical brain structures using high-resolution GluCEST MRI NMR in Biomed. 10: 1278, October 2013.

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Last updated: 05/12/2015
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