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Ravinder Reddy, PhD

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Professor of Radiology
Department: Radiology

Contact information
B1 Stellar-Chance Laboratories
422 Curie Blvd.
Philadelphia, PA 19104-6100
Office: (215) 898-5708
Fax: (215) 573-2113
Lab: (215) 898-9357
Graduate Group Affiliations
B.Sc. (Math, Physics, and Chemistry)
Osmania University , 1979.
M.Sc. (Chemistry)
Kakatiya University , 1982.
Ph.D. (Chemistry)
Indian Institute of Technology, 1989.
Post-Graduate Training
Research Assistant, Indian Institute of Technology, 1988-1989.
Post Doctoral Fellow, University of Pennsylvania, 1989-1991.
Research Associate, University of Pennsylvania, 1991-1993.
German Language Proficiency Certificate, .
Hindi Visharada Certificate , .
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Description of Research Expertise

My research interests are in developing novel, multinuclear (23Na, 17O, 13C and 1H) magnetic resonance imaging and spectroscopic techniques for the early diagnosis and quantification of physiological and functional aberrations in pathologies such as arthritis, stroke, cancer and Alzheimer’s disease. Our pulse sequence developmental approaches exploit quadrupolar spin-dynamics, polarization transfer, multiple quantum coherences, indirect detection via chemical exchange and spin-locking T1ρ MRI for studying molecular dynamics in biological tissues in vivo.

Specifically, T1ρ and Sodium MRI techniques are designed to map proteoglycan molecules (e.g. aggrecan) in cartilage as a biomarker for early arthritis in vivo. T1ρ MRI is also targeted to impart novel contrast in various tissue types (brain, connective tissues and tumors), and to detect metabolically produced H217O for studying cerebral blood flow and cerebral oxidative metabolism.

Recent developmental work on chemical exchange saturation transfer (CEST) based MRI methods is focused on measuring endogenous but low concentration metabolites in the brain, such as glutamate, myoinositol and creatine to address central nervous system disorders. In addition, a creatine CEST method is currently being explored to measure high-energy phosphate metabolism in the myocardium in heart disease.

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Selected Publications

Bagga P, Crescenzi R, Krishnamoorthy G, Verma G, Nanga RP, Reddy D, Greenberg J, Detre JA, Hariharan H, Reddy R. : Mapping the alterations in glutamate with GluCEST MRI in a mouse model of dopamine deficiency. J Neurochem. 139((3)): 432, Nov 2016.

Saxena V, D'Aquilla K, Marcoon S, Krishnamoorthy G, Gordon JA, Carey JL, Borthakur A, Kneeland JB, Kelly JD 4th, Reddy R, Sennett BJ: T1ρ Magnetic Resonance Imaging to Assess Cartilage Damage After Primary Shoulder Dislocation. Am J Sports Med. 44(11): 2800-2806, Nov 2016.

Kogan F, Stafford RB, Englund EK, Gold GE, Hariharan H, Detre JA, Reddy R.: Perfusion has no effect on the in vivo CEST effect from Cr (CrCEST) in skeletal muscle. NMR Biomed. Page: doi: 10.1002/nbm.3673, Nov 2016.

DeBrosse C, Nanga RP, Wilson N, D'Aquilla K, Elliott M, Hariharan H, Yan F, Wade K, Nguyen S, Worsley D, Parris-Skeete C, McCormick E, Xiao R, Cunningham ZZ, Fishbein L, Nathanson KL, Lynch DR, Stallings VA, Yudkoff M, Falk MJ, Reddy R, McCormack SE: Muscle oxidative phosphorylation quantitation using creatine chemical exchange saturation transfer (CrCEST) MRI in mitochondrial disorders JCI Insight 3(1(18)): e88207, Nov 2016.

Shanmugan S, Loughead J, Nanga RP, Elliott M, Hariharan H, Appleby D, Kim D, Ruparel K, Reddy R, Brown TE, Epperson CN: Lisdexamfetamine Effects on Executive Activation and Neurochemistry in Menopausal Women with Executive Function Difficulties Neuropsychopharmacology Page: doi: 10.1038/npp.2016.162, Sep 2016.

Cai K, Tain RW, Zhou XJ, Damen FC, Scotti AM, Hariharan H, Poptani H, Reddy R: Creatine CEST MRI for Differentiating Gliomas with Different Degrees of Aggressiveness Mol Imaging Biol. Aug 2016.

Nanga RP, Hariharan H, Reddy R: Fully automated macromolecule suppressed single voxel glutamate spectroscopy (FAMOUS SVGS). J Transl Med. 14(1): 220, Jul 2016.

Wilson NE, D’Aquilla K, Debrosse C, Hariharan H, Reddy R. : Localized, gradient reversed ultrafast z-spectroscopy in vivo at 7T Magn. Reson. Med. Page: doi: 10.1002/mrm.26314, July 2016.

Krishnamoorthy G, Nanga RP, Bagga P, Hariharan H, Reddy R. : High quality three-dimensional gagCEST imaging of in vivo human knee cartilage at 7 tesla. Magn Reson Med. May 2016.

Haris M, Singh A, Reddy S, Bagga P, Kneeland JB, Tjoumakaris FP, Hariharan H, Marincola FM, Reddy R. : Characterization of viscosupplementation formulations using chemical exchange saturation transfer (ViscoCEST) J. Transl. Med. Page: doi: 10.1186/s12967-016-0850-8. April 2016.

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Last updated: 02/03/2017
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