Faculty & Staff
Lewis A. Chodosh, MD, PhD
J. Samuel Staub, M.D. Professor of Cancer Biology
Member
Attending Staff Physician
Associate Professor
Member
Associate Investigator
Associate Professor
Vice Chair
Co-Director
Director
Director
Director
Executive Committee
Executive Committee
Program Leader
Chair
Department: Cancer Biology
Contact information
612 BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104
421 Curie Blvd.
Philadelphia, PA 19104
Office: (215) 898-0006
Fax: (215) 573-6725
Fax: (215) 573-6725
Email:
chodosh@mail.med.upenn.edu
chodosh@mail.med.upenn.edu
Graduate Group Affiliations
Publications
Links
Search PubMed for articles
Abramson Family Cancer Research Institute
Cell and Molecular Biology graduate group faculty webpage.
Search PubMed for articles
Abramson Family Cancer Research Institute
Cell and Molecular Biology graduate group faculty webpage.
Education:
B.S. (Molecular Biophysics & Biochemistry)
Yale University, 1981.
Ph.D. (Biochemistry)
Massachusetts Institute of Technology, 1988.
M.D.
Harvard Medical School, 1989.
B.S. (Molecular Biophysics & Biochemistry)
Yale University, 1981.
Ph.D. (Biochemistry)
Massachusetts Institute of Technology, 1988.
M.D.
Harvard Medical School, 1989.
Post-Graduate Training
Intern in Medicine, Massachusetts General Hospital, Boston, MA, 1989-1990.
Resident in Medicine, Massachusetts General Hospital, Boston, MA, 1990-1991.
Clinical Fellow in Medicine, Harvard Medical School, Boston, MA, 1991-1994.
Clinical Fellow in Endocrinology, Endocrine Division, Massachusetts General Hospital, Boston, MA, 1991-1994.
Research Fellow in Endocrinology, Endocrine Division, Massachusetts General Hospital, Boston, MA, 1992-1994.
Research Fellow in Medicine, Harvard Medical School, Boston, MA, 1992-1994.
Postdoctoral Research Fellowship, Department of Genetics, Harvard Medical School, Boston, MA, Laboratory of Dr. Philip Leder, 1992-1994.
Intern in Medicine, Massachusetts General Hospital, Boston, MA, 1989-1990.
Resident in Medicine, Massachusetts General Hospital, Boston, MA, 1990-1991.
Clinical Fellow in Medicine, Harvard Medical School, Boston, MA, 1991-1994.
Clinical Fellow in Endocrinology, Endocrine Division, Massachusetts General Hospital, Boston, MA, 1991-1994.
Research Fellow in Endocrinology, Endocrine Division, Massachusetts General Hospital, Boston, MA, 1992-1994.
Research Fellow in Medicine, Harvard Medical School, Boston, MA, 1992-1994.
Postdoctoral Research Fellowship, Department of Genetics, Harvard Medical School, Boston, MA, Laboratory of Dr. Philip Leder, 1992-1994.
Certifications
Diplomate in Internal Medicine, American Board of Internal Medicine, 1992.
Diplomate in Endocrinology and Metabolism, American Board of Internal Medicine, 1997.
Permanent linkDiplomate in Internal Medicine, American Board of Internal Medicine, 1992.
Diplomate in Endocrinology and Metabolism, American Board of Internal Medicine, 1997.
Description of Research Expertise
Research InterestsGenetically engineered mouse models for breast cancer initiation, metastasis, and recurrence.
Normal developmental biology of the mammary gland.
Tumor dormancy.
Stem cells in breast cancer and mammary development.
Oncogenes and tumor suppressors in breast cancer.
Genomics and computational biology.
Non-invasive imaging.
Key words: Mouse models, cancer, oncogenes, targeted therapy, development, genomics, computational biology, stem cells, imaging.
Description of Research
Breast cancer is the most common cancer as well as the leading cause of death from cancer among women worldwide. The Chodosh laboratory uses genetically engineered mouse models to study the genes and mechanisms that cause breast cancer and that regulate normal mammary gland development. Particular areas of interest include: the function of oncogenes and tumor suppressor genes in breast cancer, metastasis, tumor dormancy and recurrence; the role of stem cells in cancer and the normal development of the mammary gland; the use of genomics and computational approaches to understand genetic programs in mammary development and breast cancer; the mechanisms by which pregnancy protects against breast cancer; and the use of non-invasive imaging approaches such as PET, MRI, and bioluminescence to study tumor biology. These approaches employ a broad array of molecular, cellular, animal, human, and in silico model systems to study the function of key regulatory molecules in mammary gland and tumor biology.
Rotation Projects for 2009-2010
Rotation projects are available in each of the main areas of the lab.
Lab personnel:
James V. Alvarez, Ph.D. - Research Project Manager
Daniel Abravanel - Graduate Student
Chien-Chung Chen, Ph.D. - Research Project Manager
Samantha Eberle - Graduate Student
Yi Feng, Ph.D. - Postdoctoral Fellow
Ann Vernon Grey, Ph.D. - Postdoctoral Fellow
Jason Jung - Graduate Student
Zhandong Liu - Graduate Student
Heather Martin, Ph.D. - Postdoctoral Fellow
Denise Perez, Ph.D. - Research Associate
Lauren Smith - Graduate Student
Elizabeth Yeh, Ph.D. - Postdoctoral Fellow
Selected Publications
Wertheim GB, Yang TW, Pan TC, Ramne A, Liu Z, Gardner HP, Dugan KD, Kristel P, Kreike B, van de Vijver MJ, Cardiff RD, Reynolds C, Chodosh LA.: The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis. Proc Natl Acad Sci U S A 106(37): 15855-15860, 2009.Fiore F, Estebe B, Gibier P, Orsoni JC, Courbard JR, Chodosh LA, Birnbaum D, Delapeyrière O: Abnormal mammary gland development in MMTV-CBLC transgenic mouse. In Vivo 23(2): 225-229, 2009.
Debies MT, Gestl SA, Mathers JL, Mikse O, Leonard TL, Moody SE, Chodosh LA, Cardiff RD, and Gunther EJ: Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss. Journal of Clinical Investigation 118: 51-63, 2008.
Oakes SR, Naylor MJ, Asselin-Labat ML, Blazek DK, Gardiner-Garden M, Hilton HN, Kazlauskas M, Pritchard MA, Chodosh LA, Pfeffer PL, Lindeman GJ, Visvader JE, and Ormandy CJ: The Ets transcription factor Elf5 specifies alveolar cell fate. Genes & Development 22: 581-586, 2008.
Liu Z, Wang M, Alvarez JV, Bonney ME, Chen CC, D'Cruz C, Pan TC, Tadesse MG, Chodosh LA: Singular value decomposition-based regression identifies activation of endogenous signaling pathways in vivo. Genome Biology 9: R180, 2008.
Orwig KE, Ryu BY, Master S, Phillips BT, Mack M, Avarbock MR, Chodosh LA, and Brinster RL: Genes involved in post-transcriptional regulation are overrepresented in stem/progenitor spermatogonia of cryptorchid mouse testes. Stem Cells 26: 927-938, 2008.
Shen Q, Uray IP, Li Y, Zhang Y, Hill J, Xu XC, Young MR, Gunther EJ, Hilsenbeck SG, Colburn NH, Chodosh LA, Brown PH: Targeting the activator protein 1 transcription factor for the prevention of estrogen receptor-negative mammary tumors. Cancer Prevention Research 1(1): 45-55, 2008.
Sarkisian CJ, Keister BA, Stairs DB, Boxer RB, Moody SE, and Chodosh LA: Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nature Cell Biology 9: 493-505, 2007.
Jones RA, Campbell CI, Gunther EJ, Chodosh LA, Petrik JJ, Khokha R Moorehead RA: Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation Oncogene 26: 1636-1644, 2007.
Vernon AE, Bakewell SJ, and Chodosh LA: Deciphering the molecular basis of breast cancer metastasis with mouse models. Reviews in Endocrine and Metabolic Disorders 8: 199-213, 2007.
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