Faculty & Staff
Lewis A. Chodosh, MD, PhD
J. Samuel Staub, M.D. Professor of Cancer Biology
Member , Abramson Cancer Center, University of Pennsylvania School of Medicine
Attending Staff Physician, Hospital of the University of Pennsylvania
Associate Professor , Dept of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania
Member, Center for Developmental Biology, University of Pennsylvania School of Medicine
Associate Investigator, The Leonard and Madlyn Abramson Family Cancer Research Institute at the University of Pennsylvania
Associate Professor, Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine
Vice Chair, Department of Cancer Biology, University of Pennsylvania School of Medicine
Co-Director , University of Pennsylvania Small Animal Imaging Facility
Director, NCI-UPENN Mouse Models for Human Cancers Consortium
Director, Cancer Genetics, Abramson Family Cancer Research Institute
Director, UPENN DOD Breast Cancer Center of Excellence
Executive Committee, Abramson Cancer Center
Executive Committee , Abramson Family Cancer Research Institute
Program Leader , Breast Cancer Program, Abramson Cancer Center
Chair, Department of Cancer Biology, University of Pennsylvania School of Medicine
Department: Cancer Biology
Contact information
612 BRB II/III
421 Curie Blvd.
Philadelphia, PA 19104
421 Curie Blvd.
Philadelphia, PA 19104
Office: (215) 898-0006
Fax: (215) 573-6725
Fax: (215) 573-6725
Email:
chodosh@mail.med.upenn.edu
chodosh@mail.med.upenn.edu
Graduate Group Affiliations
Publications
Links
Search PubMed for articles
Cell and Molecular Biology graduate group faculty webpage.
Abramson Family Cancer Research Institute
Department of Cancer Biology
Search PubMed for articles
Cell and Molecular Biology graduate group faculty webpage.
Abramson Family Cancer Research Institute
Department of Cancer Biology
Education:
B.S. (Molecular Biophysics & Biochemistry)
Yale University, 1981.
Ph.D. (Biochemistry)
Massachusetts Institute of Technology, 1988.
M.D.
Harvard Medical School, 1989.
B.S. (Molecular Biophysics & Biochemistry)
Yale University, 1981.
Ph.D. (Biochemistry)
Massachusetts Institute of Technology, 1988.
M.D.
Harvard Medical School, 1989.
Post-Graduate Training
Intern in Medicine, Massachusetts General Hospital, Boston, MA, 1989-1990.
Resident in Medicine, Massachusetts General Hospital, Boston, MA, 1990-1991.
Clinical Fellow in Endocrinology, Endocrine Division, Massachusetts General Hospital, Boston, MA, 1991-1994.
Clinical Fellow in Medicine, Harvard Medical School, Boston, MA, 1991-1994.
Research Fellow in Endocrinology, Endocrine Division, Massachusetts General Hospital, Boston, MA, 1992-1994.
Postdoctoral Research Fellowship, Department of Genetics, Harvard Medical School, Boston, MA, Laboratory of Dr. Philip Leder, 1992-1994.
Research Fellow in Medicine, Harvard Medical School, Boston, MA, 1992-1994.
Intern in Medicine, Massachusetts General Hospital, Boston, MA, 1989-1990.
Resident in Medicine, Massachusetts General Hospital, Boston, MA, 1990-1991.
Clinical Fellow in Endocrinology, Endocrine Division, Massachusetts General Hospital, Boston, MA, 1991-1994.
Clinical Fellow in Medicine, Harvard Medical School, Boston, MA, 1991-1994.
Research Fellow in Endocrinology, Endocrine Division, Massachusetts General Hospital, Boston, MA, 1992-1994.
Postdoctoral Research Fellowship, Department of Genetics, Harvard Medical School, Boston, MA, Laboratory of Dr. Philip Leder, 1992-1994.
Research Fellow in Medicine, Harvard Medical School, Boston, MA, 1992-1994.
Certifications
Diplomate in Internal Medicine, American Board of Internal Medicine, 1992.
Diplomate in Endocrinology and Metabolism, American Board of Internal Medicine, 1997.
Permanent linkDiplomate in Internal Medicine, American Board of Internal Medicine, 1992.
Diplomate in Endocrinology and Metabolism, American Board of Internal Medicine, 1997.
Description of Research Expertise
Research InterestsGenetically engineered mouse models for breast cancer initiation, metastasis, and recurrence.
Normal developmental biology of the mammary gland.
Tumor dormancy.
Stem cells in breast cancer and mammary development.
Oncogenes and tumor suppressors in breast cancer.
Genomics and computational biology.
Non-invasive imaging.
Key words: Mouse models, cancer, oncogenes, targeted therapy, development, genomics, computational biology, stem cells, imaging.
Description of Research
Breast cancer is the most common cancer as well as the leading cause of death from cancer among women worldwide. The Chodosh laboratory uses genetically engineered mouse models to study the genes and mechanisms that cause breast cancer and that regulate normal mammary gland development. Particular areas of interest include: the function of oncogenes and tumor suppressor genes in breast cancer, metastasis, tumor dormancy and recurrence; the role of stem cells in cancer and the normal development of the mammary gland; the use of genomics and computational approaches to understand genetic programs in mammary development and breast cancer; the mechanisms by which pregnancy protects against breast cancer; and the use of non-invasive imaging approaches such as PET, MRI, and bioluminescence to study tumor biology. These approaches employ a broad array of molecular, cellular, animal, human, and in silico model systems to study the function of key regulatory molecules in mammary gland and tumor biology.
Rotation Projects for 2011-2012
Rotation projects are available in each of the main areas of the lab.
Lab personnel:
James V. Alvarez, Ph.D. - Research Project Manager
Daniel Abravanel - Graduate Student
Chien-Chung Chen, Ph.D. - Research Project Manager
Dania Daye - Graduate Student
Samantha Eberle - Graduate Student
Yi Feng, Ph.D. - Postdoctoral Fellow
Samuel Getchell - Graduate Student
Ann Vernon Grey, Ph.D. - Postdoctoral Fellow
Jason Jung - Graduate Student
Heather Martin, Ph.D. - Postdoctoral Fellow
Jason Ruth - Graduate Student
Lauren Smith - Graduate Student
Ania Warczyk - Graduate Student
Elizabeth Yeh, Ph.D. - Postdoctoral Fellow
Selected Publications
Schoenherr R, Kelly-Spratt K, Lin C, Whiteaker J, Liu T, Holzman T, Coleman I, Feng LC, Lorentzen T, Krasnoselsky A, Wang P, Liu Y, Gurley K, Amon L, Schepmoes A, Moore R, Camp D, Chodosh L, Smith R, Nelson P, McIntosh M, Kemp C, Paulovich A: Proteome and transcriptome profiles of a Her2/Neu-driven mouse model of breast cancer. Proteomics Clinical Applications 5(3-4): 179-88, 2011.Pitteri SJ, Kelly-Spratt KS, Gurley KE, Kennedy J, Busald Buson T, Chin A, Wang H, Zhang Q, Wong CH, Chodosh LA, Nelson PS, Hanash SM, Kemp CJ: Tumor Microenvironment-Derived Proteins Dominate the Plasma Proteome Response During Breast Cancer Induction and Progression. Cancer Research Epub ahead of print, 2011.
Yori JL, Seachrist DD, Johnson E, Lozada KL, Abdul-Karim FW, Chodosh LA, Schiemann WP, Keri RA: Krüppel-like Factor 4 Inhibits Tumorigenic Progression and Metastasis in a Mouse Model of Breast Cancer. Neoplasia 13(7): 601-10, 2011.
Brown RL, Reinke LM, Damerow MS, Perez D, Chodosh LA, Yang J, Cheng C: CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. Journal of Clinical Investigation 121(3): 1064-74, 2011.
Whiteaker JR, Lin C, Kennedy J, Hou L, Trute M, Sokal I, Yan P, Schoenherr RM, Zhao L, Voytovich UJ, Kelly-Spratt KS, Krasnoselsky A, Gafken PR, Hogan JM, Jones LA, Wang P, Amon L, Chodosh LA, Nelson PS, McIntosh MW, Kemp CJ, Paulovich AG: A targeted proteomics-based pipeline for verification of biomarkers in plasma. Nature Biotechnology 29(7): 625-34, 2011.
Zeng X, Shaikh FY, Harrison MK, Adon AM, Trimboli AJ, Carroll KA, Sharma N, Timmers C, Chodosh LA, Leone G, Saavedra HI: The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2. Oncogene 29(36): 5103-12, 2010.
McHenry PR, Sears JC, Herrick MP, Chang P, Heckman-Stoddard BM, Rybarczyk M, Chodosh LA, Gunther EJ, Hilsenbeck SG, Rosen JM, & Vargo-Gogola T: P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis. Breast Cancer Research 12(5): R73, 2010.
Chen CC, Boxer RB, Stairs DB, Portocarrero CP, Horton RH, Alvarez JV, Birnbaum MJ, Chodosh LA: Akt is required for Stat5 activation and mammary differentiation. Breast Cancer Research 12(5): R72, 2010.
Mazumdar J, Hickey MM, Pant DK, Durham AC, Sweet-Cordero A, Vachani A, Jacks T, Chodosh LA, Kissil JL, Simon MC, Keith B: HIF-2{alpha} deletion promotes Kras-driven lung tumor development. Proceedings of the National Academy of Sciences USA 107: 14182-14187, 2010.
Connelly L, Barham W, Pigg R, Saint-Jean L, Sherrill T, Cheng D-S, Chodosh LA, Blackwell TS, Yull FE: Activation of nuclear factor-kappa B in mammary epithelium promotes milk loss during mammary development and infection. Journal of Cell Physiology 221: 73-81, 2010.
