Faculty & Staff

Brian B. Avants, Ph.D.

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Research Assistant Professor of Radiology
Research Associate, University of Pennsylvania, Department of Radiology
Department: Radiology

Contact information
Penn Image Computing and Science Lab
3600 Market St. Suite 370
Philadelphia, PA 19104
Office: (215) 870 0787
B.A. (Physics)
New College of Florida, 1997.
M.S. (Applied Physics)
Columbia University, 1999.
M.S. (Computer Science)
University of Pennsylvania, 2002.
Ph.D. (Bioengineering)
University of Pennsylvania, 2005.
Post-Graduate Training
Research Fellow, University of Pennsylvania, 2006-2010.
Human Subjects Research Training University of Pennsylvania, 2013.
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Description of Research Expertise

Medical Image Registration

Image-Based Analysis of Pediatric Brain Development

Imaging and Clinical Effects of Frontotemporal Dementia and variants

Imaging and Clinical Effects in Traumatic Brain Injury

Lesion Analysis in the Brain

Cortical Thickness Analysis

Statistical Image Analysis

Visualization and Computation

Numerical Methods


Description of Other Expertise

Software: PipeDream - Pipedream encodes “best practice” cross-sectional and longitudinal neuroimaging studies of cortical thickness, jacobian-based morphometry and diffusion tensor imaging in a generic Pipelining infrastructure.

Software: Insight Surface Analysis and Normalization Environment (InSane, available by request): Cortical surface analysis tools for visualization, curve-guided normalization and flattening based analyses of functional and anatomical brain imagery.

Software: Advanced Normalization Tools (ANTS, http://sourceforge.net/projects/advants) : Top-Rated normalization toolkit, designed for DT and T1 MRI of the brain. Dr. Avants is the lead theoretician, designer and developer of this toolkit.

Selected Publications

Hopkins William D, Avants Brian B: Regional and hemispheric variation in cortical thickness in chimpanzees (Pan troglodytes). The Journal of neuroscience : the official journal of the Society for Neuroscience 33(12): 5241-8, Mar 2013.

McMillan Corey T, Irwin David J, Avants Brian B, Powers John, Cook Philip A, Toledo Jon B, McCarty Wood Elisabeth, Van Deerlin Vivianna M, Lee Virginia M-Y, Trojanowski John Q, Grossman Murray: White matter imaging helps dissociate tau from TDP-43 in frontotemporal lobar degeneration. Journal of neurology, neurosurgery, and psychiatry Mar 2013.

McMillan Corey T, Avants Brian, Irwin David J, Toledo Jon B, Wolk David A, Van Deerlin Vivianna M, Shaw Leslie M, Trojanoswki John Q, Grossman Murray: Can MRI screen for CSF biomarkers in neurodegenerative disease? Neurology 80(2): 132-8, Jan 2013.

Kim Junghoon, Avants Brian, Whyte John, Gee James C: Methodological considerations in longitudinal morphometry of traumatic brain injury. Frontiers in human neuroscience 7: 52, 2013.

Tustison Nicholas J, Avants Brian B, Cook Philip A, Kim Junghoon, Whyte John, Gee James C, Stone James R: Logical circularity in voxel-based analysis: Normalization strategy may induce statistical bias. Human brain mapping Nov 2012.

Badea Alexandra, Gewalt Sally, Avants Brian B, Cook James J, Johnson G Allan: Quantitative mouse brain phenotyping based on single and multispectral MR protocols. NeuroImage 63(3): 1633-45, Nov 2012.

Libon David J, McMillan Corey, Avants Brian, Boller Ashley, Morgan Brianna, Burkholder Lisa, Chandrasekaran Keerthi, Elman Lauren, McCluskey Leo, Grossman Murray: Deficits in concept formation in amyotrophic lateral sclerosis. Neuropsychology 26(4): 422-9, Jul 2012.

Hanson Jamie L, Chung Moo K, Avants Brian B, Rudolph Karen D, Shirtcliff Elizabeth A, Gee James C, Davidson Richard J, Pollak Seth D: Structural variations in prefrontal cortex mediate the relationship between early childhood stress and spatial working memory. The Journal of neuroscience : the official journal of the Society for Neuroscience 32(23): 7917-25, Jun 2012.

Jain Varsha, Duda Jeffrey, Avants Brian, Giannetta Mariel, Xie Sharon X, Roberts Timothy, Detre John A, Hurt Hallam, Wehrli Felix W, Wang Danny J J: Longitudinal reproducibility and accuracy of pseudo-continuous arterial spin-labeled perfusion MR imaging in typically developing children. Radiology 263(2): 527-36, May 2012.

Das Sandhitsu R, Avants Brian B, Pluta John, Wang Hongzhi, Suh Jung W, Weiner Michael W, Mueller Susanne G, Yushkevich Paul A: Measuring longitudinal change in the hippocampal formation from in vivo high-resolution T2-weighted MRI. NeuroImage 60(2): 1266-79, Apr 2012.

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Last updated: 05/28/2013
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