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Paul A. Yushkevich, Ph.D.

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Associate Professor of Radiology
Department: Radiology

Contact information
Penn Image Computing and Science Laboratory
Richards Building, 6th Floor, D605
3700 Hamilton Walk
Philadelphia, PA 19104
Office: 215-746-6924
Education:
B.S. (Computer Science and Mathematics)
University of North Carolina at Charlotte, 1996.
M.S. (Computer Science)
University of North Carolina Chapel Hill, 2000.
Ph.D. (Computer Science)
University of North Carolina Chapel Hill, 2003.
Post-Graduate Training
Research Fellow, Radiology, University of Pennsylvania, 2003-2006.
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Description of Research Expertise

My research portfolio combines theoretical work on statistical shape characterization using a symmetry-based representation of shape with applied and translational research in multiple areas of biomedical image analysis. I am particularly interested in analysis techniques that are tailored to specific anatomical structures. My key work in this area involves automatic segmentation and morphometry of the hippocampal formation (HF) in magnetic resonance imaging (MRI). The HF plays a central role in memory function and is a site of early neurodegeneration in Alzheimer’s disease. In a broad effort to develop more detailed imaging-based biomarkers for Alzheimer’s disease, my team has developed a first of its kind detailed computational atlas of the HF from postmortem MRI microscopy. With NIH R01 funding, we are now integrating this atlas with histology, leveraging it for the analysis of the HF and its subfields in in vivo MRI, and evaluating MRI-derived subfield-specific as alternative imaging biomarkers in dementia. We recently published a pioneering technique for automatic segmentation of HF subfields in high-resolution, HF-focused T2-weighted in vivo MRI, showing excellent agreement with manual segmentation. Concurrently, we developed and evaluated a strategy for improving the accuracy of general-purpose segmentation techniques using machine learning as a corrective wrapper method. Other recent publications include a surface-based tract-specific strategy for diffusion MRI analysis, for which open-source software is currently being developed, and an automatic cardiac MRI segmentation method with an explicit prior on heart wall thickness.

Selected Publications

Pecheva Diliana, Yushkevich Paul, Batalle Dafnis, Hughes Emer, Aljabar Paul, Wurie Julia, Hajnal Joseph V, Edwards A David, Alexander Daniel C, Counsell Serena J, Zhang Hui: A tract-specific approach to assessing white matter in preterm infants. NeuroImage 157: 675-694, Apr 2017.

Wisse Laura E M, Daugherty Ana M, Olsen Rosanna K, Berron David, Carr Valerie A, Stark Craig E L, Amaral Robert S C, Amunts Katrin, Augustinack Jean C, Bender Andrew R, Bernstein Jeffrey D, Boccardi Marina, Bocchetta Martina, Burggren Alison, Chakravarty M Mallar, Chupin Marie, Ekstrom Arne, de Flores Robin, Insausti Ricardo, Kanel Prabesh, Kedo Olga, Kennedy Kristen M, Kerchner Geoffrey A, LaRocque Karen F, Liu Xiuwen, Maass Anne, Malykhin Nicolai, Mueller Susanne G, Ofen Noa, Palombo Daniela J, Parekh Mansi B, Pluta John B, Pruessner Jens C, Raz Naftali, Rodrigue Karen M, Schoemaker Dorothee, Shafer Andrea T, Steve Trevor A, Suthana Nanthia, Wang Lei, Winterburn Julie L, Yassa Michael A, Yushkevich Paul A, la Joie Renaud: A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals? Hippocampus 27(1): 3-11, Jan 2017.

Xie Long, Pluta John B, Das Sandhitsu R, Wisse Laura E M, Wang Hongzhi, Mancuso Lauren, Kliot Dasha, Avants Brian B, Ding Song-Lin, Manjón José V, Wolk David A, Yushkevich Paul A: Multi-template analysis of human perirhinal cortex in brain MRI: Explicitly accounting for anatomical variability. NeuroImage 144(Pt A): 183-202, Jan 2017.

Wolk David A, Das Sandhitsu R, Mueller Susanne G, Weiner Michael W, Yushkevich Paul A: Medial temporal lobe subregional morphometry using high resolution MRI in Alzheimer's disease. Neurobiology of aging 49: 204-213, Jan 2017.

Win Khaing T, Pluta John, Yushkevich Paul, Irwin David J, McMillan Corey T, Rascovsky Katya, Wolk David, Grossman Murray: Neural Correlates of Verbal Episodic Memory and Lexical Retrieval in Logopenic Variant Primary Progressive Aphasia. Frontiers in neuroscience 11: 330, 2017.

Berron D, Vieweg P, Hochkeppler A, Pluta J B, Ding S-L, Maass A, Luther A, Xie L, Das S R, Wolk D A, Wolbers T, Yushkevich P A, Düzel E, Wisse L E M: A protocol for manual segmentation of medial temporal lobe subregions in 7 Tesla MRI. NeuroImage. Clinical 15: 466-482, 2017.

Gertje Eske Christiane, Pluta John, Das Sandhitsu, Mancuso Lauren, Kliot Dasha, Yushkevich Paul, Wolk David: Clinical Application of Automatic Segmentation of Medial Temporal Lobe Subregions in Prodromal and Dementia-Level Alzheimer's Disease. Journal of Alzheimer's disease : JAD 54(3): 1027-1037, Oct 2016.

Oguz Ipek, Kashyap Satyananda, Wang Hongzhi, Yushkevich Paul, Sonka Milan: Globally Optimal Label Fusion with Shape Priors. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention 9901: 538-546, Oct 2016.

Xie Long, Wisse Laura E M, Das Sandhitsu R, Wang Hongzhi, Wolk David A, Manjón Jose V, Yushkevich Paul A: Accounting for the Confound of Meninges in Segmenting Entorhinal and Perirhinal Cortices in T1-Weighted MRI. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention 9901: 564-571, Oct 2016.

Wijdh-den Hamer Inez J, Bouma Wobbe, Lai Eric K, Levack Melissa M, Shang Eric K, Pouch Alison M, Eperjesi Thomas J, Plappert Theodore J, Yushkevich Paul A, Hung Judy, Mariani Massimo A, Khabbaz Kamal R, Gleason Thomas G, Mahmood Feroze, Acker Michael A, Woo Y Joseph, Cheung Albert T, Gillespie Matthew J, Jackson Benjamin M, Gorman Joseph H, Gorman Robert C: The value of preoperative 3-dimensional over 2-dimensional valve analysis in predicting recurrent ischemic mitral regurgitation after mitral annuloplasty. The Journal of thoracic and cardiovascular surgery 152(3): 847-59, Sep 2016.

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Last updated: 08/08/2017
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