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David A Mankoff, MD, PhD

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Gerd Muehllehner Professor of Radiology
Attending Physician, University of Pennsylvania Health System
PET Center Director, University of Pennsylvania
Vice-Chair of Research, Department of Radiology, University of Pennsylvania
Department: Radiology

Contact information
Division of Nuclear Medicine
Department of Radiology
Perelman School of Medicine
116 Donner, HUP
3400 Spruce Street
Philadephia, PA 19104
Office: 215-615-3687
Fax: 215-349-5843
B.S. (Physics)
Yale University, 1981.
M.D. (Medicine)
University of Pennsylvania, 1988.
Ph.D (Bioengineering)
University of Pennsylvania, 1988.
Post-Graduate Training
Research Associate, Nuclear Medicine Section (part-time), University of Pennsylvania, 1988-1990.
Resident, Department of Internal Medicine, University of Washington Affiliated Hospitals, Seattle, WA , 1990-1992.
Resident, Division of Nuclear Medicine, University of Washington Affiliated Hospitals, Seattle, WA , 1992-1995.
Completed NMBE Examinations (Parts I-III) , 1991.
American Board of Internal Medicine, Certification for General Internal Medicine, 1993.
American Board of Nuclear Medicine, Certification for Nuclear Medicine (re-certification 2005, 2007), 1995.
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Description of Clinical Expertise

Nuclear Medicine
Radionuclide Therapy
Thyroid Cancer

Description of Research Expertise

Molecular Imaging
Breast Cancer
Quantitative Cancer Imaging
Clinical Trials

Selected Publications

Makvandi Mehran, Lieberman Brian P, LeGeyt Ben, Hou Catherine, Mankoff David A, Mach Robert H, Pryma Daniel A: The pre-clinical characterization of an alpha-emitting sigma-2 receptor targeted radiotherapeutic. Nuclear medicine and biology 43(1): 35-41, Jan 2016.

Murrey Douglas A, Hall Nathan C, Wright Chadwick L, Mankoff David A: Precise Localization of Occult Gastrointestinal Hemorrhage Using Dynamic SPECT/CT. Clinical nuclear medicine 41(1): 46-9, Jan 2016.

Kostakoglu Lale, Duan Fenghai, Idowu Michael O, Jolles Paul R, Bear Harry D, Muzi Mark, Cormack Jean, Muzi John P, Pryma Daniel A, Specht Jennifer M, Hovanessian-Larsen Linda, Miliziano John, Mallett Sharon, Shields Anthony F, Mankoff David A: A Phase II Study of 3'-Deoxy-3'-18F-Fluorothymidine PET in the Assessment of Early Response of Breast Cancer to Neoadjuvant Chemotherapy: Results from ACRIN 6688. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 56(11): 1681-9, Nov 2015.

Liu Li, Collier Ann C, Link Jeanne M, Domino Karen B, Mankoff David A, Eary Janet F, Spiekerman Charles F, Hsiao Peng, Deo Anand K, Unadkat Jashvant D: Modulation of P-glycoprotein at the Human Blood-Brain Barrier by Quinidine or Rifampin Treatment: A Positron Emission Tomography Imaging Study. Drug metabolism and disposition: the biological fate of chemicals 43(11): 1795-804, Nov 2015.

Kurland Brenda F, Muzi Mark, Peterson Lanell M, Doot Robert K, Wangerin Kristen A, Mankoff David A, Linden Hannah M, Kinahan Paul E: Multicenter clinical trials using 18F-FDG PET to measure early oncology therapy response: Effects of injection-to-acquisition time variability on required sample size. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 57(2): 226-30, Oct 2015.

Nayate A P, Dubroff J G, Schmitt J E, Nasrallah I, Kishore R, Mankoff D, Pryma D A: Use of Standardized Uptake Value Ratios Decreases Interreader Variability of [18F] Florbetapir PET Brain Scan Interpretation. AJNR. American journal of neuroradiology 36(7): 1237-44, Jul 2015.

Harrison RL, Elston BF, Doot RK, Lewellen TK, Mankoff DA, Kinahan PE.: A virtual clinical trial of FDG-PET imaging of breast cancer: effect of variability on response assessment. Transl Oncol 7:138-146, 2014. Transl Oncol 7:138-146 2014.

Peterson LM, Kurland BF, Schubert EK, Link JM, Gadi VK, Specht JM, Eary JF, Porter P, Shankar LK, Mankoff DA, Linden HM.: A phase 2 study of 16α-[18F]-fluoro-17β-estradiol positron emission tomography (FES-PET) as a marker of hormone sensitivity in metastatic breast cancer (MBC). Mol Imaging Biol 16: 431-470 2014.

Deo AK, Borson S, Link JM, Domino K, Eary JF, Ke B, Richards TL, Mankoff DA, Minoshima S, O'Sullivan F, Eyal S, Hsiao P, Maravilla K, Unadkat JD. : Activity of P-glycoprotein, a β-amyloid transporter at the blood-brain barrier, is compromised in patients with mild Alzheimer disease. J Nucl Med 55:1106-1111 2014.

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Last updated: 10/27/2016
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