Faculty & Staff

David A Mankoff, MD, PhD

faculty photo
Gerd Muehllehner Professor of Radiology
Attending Physician, University of Pennsylvania Health System
Department: Radiology

Contact information
Division of Nuclear Medicine
Department of Radiology
Perelman School of Medicine
116 Donner, HUP
3400 Spruce Street
Philadephia, PA 19104
Office: 215-615-3687
Fax: 215-349-5843
Education:
B.S. (Physics)
Yale University, 1981.
Ph.D (Bioengineering)
University of Pennsylvania, 1988.
M.D. (Medicine)
University of Pennsylvania, 1988.
Post-Graduate Training
Research Associate, Nuclear Medicine Section, University of Pennsylvania, 1988-1990.
Director of Engineering, UGM Medical Systems, Philadelphia, PA, 1989-1990.
Research Scientist , UGM Medical Systems , 1989-1990.
Resident, Department of Internal Medicine, University of Washington Affiliated Hospitals, Seattle, WA , 1990-1992.
Resident, Division of Nuclear Medicine, University of Washington Affiliated Hospitals, Seattle, WA , 1992-1995.
Certifications
Completed NMBE Examinations (Parts I-III) , 1991.
American Board of Internal Medicine, Certification for General Internal Medicine, 1993.
American Board of Nuclear Medicine, Certification for Nuclear Medicine (re-certification 2005, 2007), 1995.
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Description of Clinical Expertise

Nuclear Medicine
Radionuclide Therapy
Thyroid Cancer

Description of Research Expertise

Molecular Imaging
Breast Cancer
Quantitative Cancer Imaging
Clinical Trials

Selected Publications

Eckelman WC, Mankoff DA: Choosing a single target as a biomarker or therapeutic using radioactive probes. Nucl Med Biol e-pub, 2015.

Yu EY, Duan F, Muzi M, Deng X, Chin BB, Alumkal JJ, Taplin ME, Taub JM, Herman B, Higano CS, Doot RK, Hartfeil D, Febbo PG, Mankoff DA: Castration-Resistant Prostate Cancer Bone Metastasis Response Measured by 18F-Fluoride PET After Treatment with Dasatinib and Correlation with Progression-Free Survival: Results from American College of Radiology Imaging Network 6687. J Nucl Med 56: 354 - 360, 2015.

Doot RK, McDonald ES, Mankoff DA. : Role of PET quantitation in the monitoring of cancer response to treatment: Review of approaches and human clinical trials. Clin Transl Imaging 2(4):295-303 2014.

Farwell MD, Pryma DA, Mankoff DA.: PET/CT imaging in cancer: Current applications and future directions. Cancer 20(22):3433-45 2014.

Peterson LM, Kurland BF, Schubert EK, Link JM, Gadi VK, Specht JM, Eary JF, Porter P, Shankar LK, Mankoff DA, Linden HM.: A phase 2 study of 16α-[18F]-fluoro-17β-estradiol positron emission tomography (FES-PET) as a marker of hormone sensitivity in metastatic breast cancer (MBC). Mol Imaging Biol 16: 431-470 2014.

Clark AS, McDonald E, Lynch MC, Mankoff D. : Using nuclear medicine imaging in clinical practice: update on PET to guide treatment of patients with metastatic breast cancer. Oncology 28(5):424-30 2014.

Mankoff DA, Pryma DA, Clark AS: Molecular imaging biomarkers for oncology clinical trials. J Nucl Med 55:525,-528 2014.

Deo AK, Borson S, Link JM, Domino K, Eary JF, Ke B, Richards TL, Mankoff DA, Minoshima S, O'Sullivan F, Eyal S, Hsiao P, Maravilla K, Unadkat JD. : Activity of P-glycoprotein, a β-amyloid transporter at the blood-brain barrier, is compromised in patients with mild Alzheimer disease. J Nucl Med 55:1106-1111 2014.

Harrison RL, Elston BF, Doot RK, Lewellen TK, Mankoff DA, Kinahan PE.: A virtual clinical trial of FDG-PET imaging of breast cancer: effect of variability on response assessment. Transl Oncol 7:138-146, 2014. Transl Oncol 7:138-146 2014.

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Last updated: 05/29/2015
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