Faculty & Staff

David A Mankoff, MD, PhD

faculty photo
Gerd Muehllehner Professor of Radiology
Attending Physician, University of Pennsylvania Health System
Department: Radiology

Contact information
Division of Nuclear Medicine
Department of Radiology
Perelman School of Medicine
116 Donner, HUP
3400 Spruce Street
Philadephia, PA 19104
Office: 215-615-3687
Fax: 215-349-5843
Education:
B.S. (Physics)
Yale University, 1981.
Ph.D (Bioengineering)
University of Pennsylvania, 1988.
M.D. (Medicine)
University of Pennsylvania, 1988.
Post-Graduate Training
Research Associate, Nuclear Medicine Section, University of Pennsylvania, 1988-1990.
Director of Engineering, UGM Medical Systems, Philadelphia, PA, 1989-1990.
Research Scientist , UGM Medical Systems , 1989-1990.
Resident, Department of Internal Medicine, University of Washington Affiliated Hospitals, Seattle, WA , 1990-1992.
Resident, Division of Nuclear Medicine, University of Washington Affiliated Hospitals, Seattle, WA , 1992-1995.
Certifications
Completed NMBE Examinations (Parts I-III) , 1991.
American Board of Internal Medicine, Certification for General Internal Medicine, 1993.
American Board of Nuclear Medicine, Certification for Nuclear Medicine (re-certification 2005, 2007), 1995.
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Description of Clinical Expertise

Nuclear Medicine
Radionuclide Therapy
Thyroid Cancer

Description of Research Expertise

Molecular Imaging
Breast Cancer
Quantitative Cancer Imaging
Clinical Trials

Selected Publications

Eckelman WC, Mankoff DA: Choosing a single target as a biomarker or therapeutic using radioactive probes. Nucl Med Biol e-pub, 2015.

A.P. Nayate, J.G. Dubroff, J.E. Schmitt, I. Nasrallah, R. Kishore, D.Mankoff, and D.A. Pryma: "Use of Standardized Uptake Value Ratios Decreases Interreader Variability of [18F] Florbetapir PET Brain Scan Interpretation" AJNR 2015.

Yu EY, Duan F, Muzi M, Deng X, Chin BB, Alumkal JJ, Taplin ME, Taub JM, Herman B, Higano CS, Doot RK, Hartfeil D, Febbo PG, Mankoff DA: Castration-Resistant Prostate Cancer Bone Metastasis Response Measured by 18F-Fluoride PET After Treatment with Dasatinib and Correlation with Progression-Free Survival: Results from American College of Radiology Imaging Network 6687. J Nucl Med 56: 354 - 360, 2015.

Doot RK, McDonald ES, Mankoff DA. : Role of PET quantitation in the monitoring of cancer response to treatment: Review of approaches and human clinical trials. Clin Transl Imaging 2(4):295-303 2014.

Farwell MD, Pryma DA, Mankoff DA.: PET/CT imaging in cancer: Current applications and future directions. Cancer 20(22):3433-45 2014.

Peterson LM, Kurland BF, Schubert EK, Link JM, Gadi VK, Specht JM, Eary JF, Porter P, Shankar LK, Mankoff DA, Linden HM.: A phase 2 study of 16α-[18F]-fluoro-17β-estradiol positron emission tomography (FES-PET) as a marker of hormone sensitivity in metastatic breast cancer (MBC). Mol Imaging Biol 16: 431-470 2014.

Clark AS, McDonald E, Lynch MC, Mankoff D. : Using nuclear medicine imaging in clinical practice: update on PET to guide treatment of patients with metastatic breast cancer. Oncology 28(5):424-30 2014.

Mankoff DA, Pryma DA, Clark AS: Molecular imaging biomarkers for oncology clinical trials. J Nucl Med 55:525,-528 2014.

Deo AK, Borson S, Link JM, Domino K, Eary JF, Ke B, Richards TL, Mankoff DA, Minoshima S, O'Sullivan F, Eyal S, Hsiao P, Maravilla K, Unadkat JD. : Activity of P-glycoprotein, a β-amyloid transporter at the blood-brain barrier, is compromised in patients with mild Alzheimer disease. J Nucl Med 55:1106-1111 2014.

Harrison RL, Elston BF, Doot RK, Lewellen TK, Mankoff DA, Kinahan PE.: A virtual clinical trial of FDG-PET imaging of breast cancer: effect of variability on response assessment. Transl Oncol 7:138-146, 2014. Transl Oncol 7:138-146 2014.

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Last updated: 05/29/2015
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