Faculty & Staff

Despina Kontos, Ph.D.

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Assistant Professor of Radiology
Department: Radiology

Contact information
Computational Breast Imaging Group (CBIG)
University of Pennsylvania, Department of Radiology
Rm D702 Richards Bldg., 3700 Hamilton Walk
Philadelphia, PA 19104
Office: 215-746-4064
Lab: 215-746-4060
B.Eng. (Computer Engineering and Informatics )
University of Patras, Greece, 2000.
M.Sc. (Computer and Information Sciences )
Temple University, Philadelphia PA , 2003.
Ph.D. (Computer and Information Sciences )
Temple University, Philadelphia PA , 2006.
Post-Graduate Training
Fellow in Basic Radiologic Sciences, Radiological Society of North America (RSNA), Department of Radiology, University of Pennsylvania, Philadelphia PA (Research Fellowship) , 2006-2007.
Fellow in Basic Radiologic Sciences, Radiological Society of North America (RSNA), Department of Radiology, University of Pennsylvania, Philadelphia PA (Research Fellowship) , 2007-2008.
Fellow in Radiology-Physics and Breast Imaging, Susan G. Komen for the Cure Foundation, Department of Radiology, University of Pennsylvania, Philadelphia PA (Research Fellowship), 2008-2010.
Clinical Research Certificate, Center for Clinical Epidemiology and Biostatistics (CCEB) University of Pennsylvania, Philadelphia PA, 2009.
Total Leadership Program, an innovative program developed by Dr. Stewart Friedman at Wharton School of the University of Pennsylvania, offered as part of an NIH study to promote women’s success in Academic Medicine, Philadelphia PA., 2010.
Research Mentor Training, a Course Series of six two-hour Case-Based training sessions designed to enhance specific skills in being an effective Mentor, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. , 2014.
Interpersonal Dynamics Training, office of Organization Effectiveness on personality styles and group dynamics using the Myers-Briggs Type Indicator, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA., 2014.
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Description of Research Expertise

Biomedical image analysis; Quantitative imaging biomarkers; Pattern recognition; Identification, characterization and validation of imaging biomarkers; Evaluation of genotype to phenotype associations via imaging; Integrated diagnostics; Risk prediction; Personalized screening, prognostication and treatment of breast cancer.

Selected Publications

B.M. Keller, J. Chen, D. Daye, E.F. Conant, D. Kontos: Preliminary evaluation of the publicly available Laboratory for Breast Radiodensity Assessment (LIBRA) software tool: Comparison of fully-automated area and volumetric density measures in a case-control study with digital mammography. Breast Cancer Research 17(1): 117; doi: 10.1186/s13058-015-0626-8. Aug 2015.

AM. McCarthy, D. Kontos, M. Synnestvedt, K. Tan, D.F. Heitjan, M. Schnall, E.F. Conant: Screening Outcomes Following Implementation of Digital Breast Tomosynthesis in a General-Population Screening Program. Journal of the National Cancer Institute (JNCI) 106(11): dju316, Oct 2014.

S. Wu, S.P. Weinstein, M.J. Deleo, E.F. Conant, J. Chen, S.M. Domchek, D. Kontos : Quantitative assessment of Background Parenchymal Enhancement in breast MRI predicts response to Risk-Reducing Salpingo-Oophorectomy: Preliminary evaluation in a cohort of BRCA1/2 mutation carriers. Breast Cancer Research 17(67): doi: 10.1186/s13058-015-0577-0, May 2015.

Y. Ou, SP. Weinstein, E.F. Conant, S. Englander, X. Da, B. Gaonkar, M-K. Hsieh, M. Rosen, A. DeMichele, C. Davatzikos, D. Kontos: Deformable registration for quantifying longitudinal tumor changes during neoadjuvant chemotherapy. Magnetic Resonance in Medicine (MRM) 73(6): 2343-56, Jun 2015.

A.B. Ashraf, D. Daye, S. Gavenonis, C. Mies, M. Feldman, M. Rosen, D. Kontos: Identification of intrinsic radio-phenotypes for breast cancer tumors: Preliminary associations with gene expression profiles. Radiology 272(2): 374-84, Aug 2014.

A.M. McCarthy, B. Keller, D. Kontos, L. Boghossian, E. McGuire, M. Bristol, J. Chen, S.M. Domchek, K. Armstrong: The use of the Gail Model, body mass index (BMI), and SNPs, to predict breast cancer among women with abnormal (BI-RADS 4) mammograms. Breast Cancer Research 17(1): doi: 10.1186/s13058-014-0509-4, Jan 2015.

S.Wu, S.P. Weinstein, E.F. Conant, D. Kontos: Automated fibroglandular tissue segmentation and volumetric density estimation in breast MRI using an atlas-aided fuzzy C-means method Medical Physics 40(12): 122302, Dec 2013.

A. Ashraf, S. Gavenonis, D. Daye, C. Mies, M. Feldman, M.A. Rosen, and D. Kontos: A Multichannel Markov Random Field Framework for Tumor Segmentation with an Application to Classification of Gene Expression-based Breast Cancer Recurrence Risk. IEEE Transactions on Medical Imaging 32(4): 637-48, Apr 2013.

B.M. Keller, D.L. Nathan, Y. Wang, Y. Zheng, J.C. Gee, E.F. Conant, D. Kontos: Estimation of Breast Percent Density in Raw and Processed Full Field Digital Mammography Images via Adaptive Fuzzy C-means Clustering and Support Vector Machine Segmentation. Medical Physics 39(8): 4903-17, Aug 2012.

D. Kontos, L. Ikejimba, P.R. Bakic, A.B. Troxel,E.F. Conant, A.D.A. Maidment: Digital Breast Tomosynthesis Parenchymal Texture Analysis: Comparison with Digital Mammography and Implications for Cancer Risk Assessment. Radiology 261(1): 80-91, Oct 2011

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Last updated: 05/05/2016
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