Faculty & Staff

Eric Wickstrom, Ph.D.

faculty photo
Adjunct Professor of Radiology
Department: Radiology

Contact information
Laboratory of Molecular Design, Department of Biochemistry & Molecular Biology, Thomas Jefferson University, Bluemle Life Sciences Bldg 219, 233 S. 10th St.
Philadelphia, PA 19107-5441
Office: 215-955-4578
Fax: 215-955-4580
Lab: 215-955-4579
BS Honors (Biology)
California Institute of Technology, 1968.
Ph.D. (Chemistry)
University of California, Berkeley, 1972.
Post-Graduate Training
Research Associate, Chemistry, and Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, 1973-1974.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

nucleic acid chemistry, biophysical properties, functional interactions
oncogene mRNAs
neurological mRNAs

Selected Publications

Yuan-Yuan Jin, Jade Andrade, and Eric Wickstrom: Non-specific blocking of miR-17-5p guide strand in triple negative breast cancer cells by amplifying passenger strand activity. Public Library of Science 10(11): accepted for publication, November 2015.

Wickstrom Eric: DNA and RNA derivatives to optimize distribution and delivery. Advanced drug delivery reviews 87: 25-34, Jun 2015.

Sonar Mahesh V, Wampole Matthew E, Jin Yuan-Yuan, Chen Chang-Po, Thakur Mathew L, Wickstrom Eric: Fluorescence detection of KRAS2 mRNA hybridization in lung cancer cells with PNA-peptides containing an internal thiazole orange. Bioconjugate chemistry 25(9): 1697-708, Sep 2014.

Jin Lianjin, Lim Meng, Zhao Shuping, Sano Yuri, Simone Brittany A, Savage Jason E, Wickstrom Eric, Camphausen Kevin, Pestell Richard G, Simone Nicole L: The metastatic potential of triple-negative breast cancer is decreased via caloric restriction-mediated reduction of the miR-17~92 cluster. Breast cancer research and treatment 146(1): 41-50, Jul 2014.

Wampole, M.E., Kairys, J. C., Mitchell, E. P., Ankeny, M. L., Thakur, M. L., and Wickstrom, E.: Consistent surgeon evaluations of three-dimensional rendering of PET/CT scans of the abdomen of a patient with a ductal pancreatic mass. PLoS One 9: Epub ahead of print, Sept 2013.

Paudyal, B., Zhang, K., Chen, C.-P., Mehta, N., Wampole, M. E., Mitchell, E. P., Gray, B. D., Mattis, J. A., Pak, K.-Y., Thakur, M. L., and Wickstrom, E. : Determining efficacy of breast cancer therapy by PET imaging of HER2 mRNA. Nuclear Medicine and Biology 40: Epub ahead of print, Sept 2013.

Sanders JM, Wampole ME, Chen C, Sethi DD, Singh A, Dupradeau FY, Wang F, Gray BD, Thakur ML, Wickstrom E.: Effects of Hypoxanthine Substitution in Peptide Nucleic Acids Targeting KRAS2 Oncogenic mRNA Molecules: Theory and Experiment. J Phys Chem B. American Chemical Society, 117: Epub ahead of print, August 2013.

Thakur Mathew L, Zhang Kaijun, Berger Adam, Cavanaugh Barbara, Kim Sung, Channappa Chaitra, Frangos Andrea J, Wickstrom Eric, Intenzo Charles M: VPAC1 Receptors for Imaging Breast Cancer: A Feasibility Study. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 54(7): 1019-25, Jul 2013.

Opitz Armin W, Czymmek Kirk J, Wickstrom Eric, Wagner Norman J: Uptake, efflux, and mass transfer coefficient of fluorescent PAMAM dendrimers into pancreatic cancer cells. Biochimica et biophysica acta 1828(2): 294-301, Feb 2013.

Sanders Jeffrey M, Wampole Matthew E, Thakur Mathew L, Wickstrom Eric: Molecular determinants of epidermal growth factor binding: a molecular dynamics study. PloS one 8(1): e54136, Jan 2013.

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Last updated: 10/31/2015
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