Faculty & Staff

Kavindra Nath, PhD

faculty photo
Research Assistant Professor of Radiology
Department: Radiology

Contact information
B6 Blockley Hall
423 Guardian Drive
Perelman School of Medicine
Department of Radiology
University of Pennsylvania
Philadelphia, PA 19104
Education:
M.Sc. (Biochemistry)
Dr. Ram Manohar Lohia Avadh University, Faizabad, UP, India, 2002.
Ph.D. (Life Sciences; Magnetic Resonance Imaging)
Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow UP, India, 2008.
Post-Graduate Training
Post Doc Fellow, Department of Imaging, Moffitt Cancer Center, Tampa, Florida, USA, 2008-2009.
Post Doc Fellow, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA , 2009-2013.
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Description of Research Expertise

Selective acidification and de-energization of cancers by inhibition of monocarboxylate transporters (MCTs),mitochondrial pyruvate carrier (MPC)
Development of a safe and reproducible method to selectively acidify the human melanoma xenografts and other cancers. Specifically, we seek to employ the natural tendency of melanomas and other tumors to convert glucose to lactate as a method for selective intracellular acidification of the tumor, which is known to potentiate tumor response to radiation therapy, hyperthermia as well as to chemotherapy with platinum, N-mustard and anthracyclines alkylating agents such as cisplatin, cyclophosphamide, melphalan and doxorubicin. In vivo 31Phosphorus Magnetic Resonance Spectroscopy demonstrated that human melanoma xenografts and other cancers such as breast, prostate and ovarian in immunosuppressed mice treated with the MCT and MPC inhibitor lonidamine (100 mg/kg, intraperitoneal) exhibit a sustained and tumor-selective decrease in pH, bioenergetics and subsequent sensitization with melphalan and doxorubicin in combination with lonidamine.
Expertise
Xenografts development (melanoma, breast, prostate, ovarian, lymphoma etc.) in nude mice, cell culture and drug delivery.
Surface coil development compatible to animal scanner.
Proton, Phosphorus, Carbon Spectroscopy, Dynamic Contrast Enhanced (DCE) MRI, T-1, T-2 and Diffusion weighted MRI, for mice with subcutaneous tumor on 9.4 Tesla horizontal varion animal scanner.
Diffusion tensor imaging and proton magnetic resonance spectroscopy in patients with brain abscess, brain tumor, meningitis, neurocysticercosis and liver failure on GE clinical scanner.
Measurement of test-retest reproducibility of SUV (Subsidized Uptake Value) on PET under clinical practice conditions in cancer patients.

Selected Publications

Guo L, Shestov AA, Worth AJ, Nath K, Nelson DS, Leeper DB, Glickson JD, Blair IA. : Inhibition of mitochondrial complex II by the anti-cancer agent lonidamine. J Biol Chem. 291(1): 42-57, 2016.

Nancolas B, Guo L, Zhou R, Nath K, Nelson DS, Leeper DB, Blair IA, Glickson JD, Halestrap AP.: The anti-tumour agent lonidamine is a potent inhibitor of the mitochondrial pyruvate carrier and plasma membrane monocarboxylate transporters. Biochem J. 473(7): 929-36, 2016.

De Brosse K, Nanga R, Bagga P, Nath K, Haris M, Marincola F, Schnall M, Hariharan H, Reddy R: Lactate Chemical Exchange Saturation Transfer (LATEST) Imaging in vivo: A Biomarker for LDH Activity. Sci Rep. 6: 19517, 2016.

Nath Kavindra, Nelson David S, Heitjan Daniel F, Leeper Dennis B, Zhou Rong, Glickson Jerry D: Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin. NMR in Biomedicine 28(3): 281-290, 2015.

Nath Kavindra, Nelson David S, Heitjan Daniel F, Zhou Rong, Leeper Dennis B, Glickson Jerry D. : Effects of hyperglycemia on lonidamine-induced acidification and de-energization of human melanoma xenografts and sensitization to melphalan. NMR in Biomedicine 28(3): 395-403, 2015.

Ting Liu, Kavindra Nath, Weixia Liu, Rong Zhou, I-Wei Chen: A study of the relationship of metabolic MR parameters to estrogen dependence in breast cancer xenografts. NMR in Biomedicine 28(9): 1087-96, 2015.

Haris Mohammad, Singh Anup, Mohammed Imran, Ittyerah Ranjit, Nath Kavindra, Nanga Ravi Prakash Reddy, Debrosse Catherine, Kogan Feliks, Cai Kejia, Poptani Harish, Reddy Damodar, Hariharan Hari, Reddy Ravinder: In vivo magnetic resonance imaging of tumor protease activity. Scientific Reports 4: 6081, 2014.

Haris Mohammad, Singh Anup, Cai Kejia, Nath Kavindra, Verma Gaurav, Nanga Ravi Prakash Reddy, Hariharan Hari, Detre John A, Epperson Neill, Reddy Ravinder: High resolution mapping of modafinil induced changes in glutamate level in rat brain. PloS One 9(7): e103154, 2014.

Kumar Virendra, Nath Kavindra, Berman Claudia G, Kim Jongphil, Tanvetyanon Tawee, Chiappori Alberto A, Gatenby Robert A, Gillies Robert J, Eikman Edward A: Variance of SUVs for FDG-PET/CT is greater in clinical practice than under ideal study settings. Clinical Nuclear Medicine 38(3): 175-82, 2013.

Nath Kavindra, Nelson David S, Ho Andrew M, Lee Seung-Cheol, Darpolor Moses M, Pickup Stephen, Zhou Rong, Heitjan Daniel F, Leeper Dennis B, Glickson Jerry D: (31) P and (1) H MRS of DB-1 melanoma xenografts: lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan. NMR in Biomedicine 26(1): 98-105, 2013.

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Last updated: 04/19/2016
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