Faculty & Staff

Kavindra Nath, PhD

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Research Associate of Radiology
Department: Radiology

Contact information
B6 Blockley Hall
423 Guardian Drive
Perelman School of Medicine
Department of Radiology
University of Pennsylvania
Philadelphia, PA 19104
Education:
MSc (Biochemistry)
Dr. Ram Manohar Lohia Avadh University, Faizabad, UP, India, 2002.
PhD (Life Sciences (Magnetic Resonance Imaging))
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP, India/CSJM University Kanpur, 2008.
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Description of Research Expertise

Selective Acidification of cancers by inhibition of monocarboxylic acid transporters
Development of a safe and reproducible method to selectively acidify the human melanoma xenografts and other cancers. Specifically, we seek to employ the natural tendency of melanomas and other tumors to convert glucose to lactate as a method for selective intracellular acidification of the tumor, which is known to potentiate tumor response to hyperthermia as well as to chemotherapy with platinum, N-mustard and anthracyclines alkylating agents such as cisplatin, cyclophosphamide, melphalan and doxorubicin. In vivo 31Phosphorus Magnetic Resonance Spectroscopy demonstrated that human melanoma xenografts and other cancers such as breast, prostate and ovarian in immunosuppressed mice treated with the monocarboxylate transport (MCT) inhibitor lonidamine (100 mg/kg, intraperitoneal) exhibit a sustained and tumor-selective decrease in pH, bioenergetics and subequent sensitization with melphalan and doxorubicin in combination with lonidamine.

Selected Publications

Kumar V, Nath K, Berman CG, Kim J, Tanvetyanon T, Chiappori AA, Gatenby RA, Gillies RJ, Eikman EA: Variance of standardized Uptake Values for FDG-PET/CT Greater in Clinical Practice than Under Ideal Study Settings. Clin Nucl Med. 2013.

Nath K, Nelson DS, Ho A, Lee SC, Darpolor M, Pickup S, Zhou R, Leeper DB, Glickson JD: 31P and 1H MRS of DB-1 Melanoma Xenografts: Lonidamine Selectively Decreases Tumor Intracellular pH and Energy Status and Sensitizes Tumors to Melphalan. NMR Biomed 26(1), 2013.

Haris M, Nath K, Cai K, Singh A, Crescenzi R, Kogan F, Verma G, Reddy S, Hariharan H, Melhem ER, Reddy R: Imaging of glutamate neurotransmitter alterations in Alzheimer's disease. NMR Biomed 2012.

Haris M, Singh A, Cai K, Nath K, Crescenzi R, Kogan F, Hariharan H, Reddy R: MICEST: A Potential Tool for Non-invasive Detection of Molecular Changes in Alzheimer's Disease. J Neurosci Methods 2012.

Nath K, Ramola M, Husain M, Kumar M, Prasad KN, Gupta RK: Assessment of Therapeutic Response in Patients with Brain Abscess using Diffusion Tensor Imaging World Neurosurg 2010.

Prasad A, Prasad KN, Gupta RK, Nath K, Pradhan S, Tripathi M, Pandey CM: Neurocysticercosis in Patients with Active Epilepsy from a Pig Farming Community. Trans R Soc Trop Med Hyg 2009.

Nath K, Agarwal M, Ramola M, Husain M, Prasad KN, Rathore RKS, Pandey CM, Gupta RK: Role of diffusion tensor imaging (DTI) and in vivo proton MR Spectroscopy (PMRS) in the differential diagnosis of cystic intracranial mass lesions. Magn Reson Imaging 2009.

Yadav A, Malik GK, Trivedi R, Prasad A, Nath K, Prasad KN, Rathore RKS, Tripathi RP, Gupta RK: Correlation of Neuroinflammatory molecules (NMs) quantified from CSF with fractional anisotropy in the neonatal meningitis. Magn Reson Imaging 2009.

Saraswat VA, Saksena S, Nath K, Mandal P, Singh J, Thomas MA, Rathore RKS, Gupta RK: Evaluation of Mannitol Effect in Patients with Fulminant Hepatic Failure and Acute-on-Chronic Liver Failure using Conventional MRI, Diffusion Tensor Imaging and In-vivo Proton MR Spectroscopy. World J Gastroenterol 2008.

Nath K, Saraswat VA, Yellapu R K, Thomas MA, Rathore RKS, Pandey CM, Gupta RK: Quantification of Cerebral Edema on Diffusion Tensor Imaging in Acute-on-Chronic Liver Failure. NMR in Biomedicine 2008.

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Last updated: 05/12/2013
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