Faculty & Staff

Kavindra Nath, PhD

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Research Associate of Radiology
Research Associate, Department of Radiology
Department: Radiology

Contact information
B6 Blockley Hall
423 Guardian Drive
Perelman School of Medicine
Department of Radiology
University of Pennsylvania
Philadelphia, PA 19104
M.Sc. (Biochemistry)
Dr. Ram Manohar Lohia Avadh University, Faizabad, UP, India, 2002.
Ph.D. (Life Sciences (Magnetic Resonance Imaging))
Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow UP, India, 2008.
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Description of Clinical Expertise

Diffusion tensor imaging and proton magnetic resonance spectroscopy in patients with brain abscess, brain tumor, meningitis, neurocysticercosis and liver failure on GE scanner.
Measurement of test-retest reproducibility of SUV (Subsidized Uptake Value) on PET under clinical practice conditions in cancer patients.

Description of Research Expertise

Selective Acidification of cancers by inhibition of monocarboxylate transporters (MCTs)
Development of a safe and reproducible method to selectively acidify the human melanoma xenografts and other cancers. Specifically, we seek to employ the natural tendency of melanomas and other tumors to convert glucose to lactate as a method for selective intracellular acidification of the tumor, which is known to potentiate tumor response to hyperthermia as well as to chemotherapy with platinum, N-mustard and anthracyclines alkylating agents such as cisplatin, cyclophosphamide, melphalan and doxorubicin. In vivo 31Phosphorus Magnetic Resonance Spectroscopy demonstrated that human melanoma xenografts and other cancers such as breast, prostate and ovarian in immunosuppressed mice treated with the MCT inhibitor lonidamine (100 mg/kg, intraperitoneal) exhibit a sustained and tumor-selective decrease in pH, bioenergetics and subsequent sensitization with melphalan and doxorubicin in combination with lonidamine.
Xenografts development (melanoma, breast, prostate, ovarian, lymphoma etc.) in nude mice, cell culture and drug delivery.
Solenoidal surface coil development compatible to 9.4 Tesla horizontal animal scanner.
Proton, Phosphorus, Carbon Spectroscopy, Dynamic Contrast Enhanced (DCE) MRI, T-1, T-2 and Diffusion weighted MRI, in mice with subcutaneous tumor on 9.4 Tesla horizontal animal scanner.

Selected Publications

Nath Kavindra, Nelson David S, Heitjan Daniel F, Leeper Dennis B, Zhou Rong, Glickson Jerry D: Lonidamine induces intracellular tumor acidification and ATP depletion in breast, prostate and ovarian cancer xenografts and potentiates response to doxorubicin. NMR in Biomedicine 28(3): 281-290, 2015.

Nath Kavindra, Nelson David S, Heitjan Daniel F, Zhou Rong, Leeper Dennis B, Glickson Jerry D. : Effects of hyperglycemia on lonidamine-induced acidification and de-energization of human melanoma xenografts and sensitization to melphalan. NMR in Biomedicine 28(3): 395-403, 2015.

Ting Liu, Kavindra Nath, Weixia Liu, Rong Zhou, I-Wei Chen: A study of the relationship of metabolic MR parameters to estrogen dependence in breast cancer xenografts. NMR in Biomedicine 28(9): 1087-96, 2015.

Haris Mohammad, Singh Anup, Mohammed Imran, Ittyerah Ranjit, Nath Kavindra, Nanga Ravi Prakash Reddy, Debrosse Catherine, Kogan Feliks, Cai Kejia, Poptani Harish, Reddy Damodar, Hariharan Hari, Reddy Ravinder: In vivo magnetic resonance imaging of tumor protease activity. Scientific Reports 4: 6081, 2014.

Haris Mohammad, Singh Anup, Cai Kejia, Nath Kavindra, Verma Gaurav, Nanga Ravi Prakash Reddy, Hariharan Hari, Detre John A, Epperson Neill, Reddy Ravinder: High resolution mapping of modafinil induced changes in glutamate level in rat brain. PloS One 9(7): e103154, 2014.

Kumar Virendra, Nath Kavindra, Berman Claudia G, Kim Jongphil, Tanvetyanon Tawee, Chiappori Alberto A, Gatenby Robert A, Gillies Robert J, Eikman Edward A: Variance of SUVs for FDG-PET/CT is greater in clinical practice than under ideal study settings. Clinical Nuclear Medicine 38(3): 175-82, 2013.

Haris Mohammad, Nath Kavindra, Cai Kejia, Singh Anup, Crescenzi Rachelle, Kogan Feliks, Verma Gaurav, Reddy Sanjana, Hariharan Hari, Melhem Elias R, Reddy Ravinder: Imaging of glutamate neurotransmitter alterations in Alzheimer's disease. NMR in Biomedicine 26(4): 386-91, 2013.

Haris Mohammad, Singh Anup, Cai Kejia, Nath Kavindra, Crescenzi Rachelle, Kogan Feliks, Hariharan Hari, Reddy Ravinder: MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer's disease. Journal of Neuroscience Methods 212(1): 87-93, 2013.

Nath Kavindra, Nelson David S, Ho Andrew M, Lee Seung-Cheol, Darpolor Moses M, Pickup Stephen, Zhou Rong, Heitjan Daniel F, Leeper Dennis B, Glickson Jerry D: (31) P and (1) H MRS of DB-1 melanoma xenografts: lonidamine selectively decreases tumor intracellular pH and energy status and sensitizes tumors to melphalan. NMR in Biomedicine 26(1): 98-105, 2013.

Nath Kavindra, Ramola Mahesh, Husain Mazhar, Kumar Manoj, Prasad Kashi, Gupta Rakesh: Assessment of therapeutic response in patients with brain abscess using diffusion tensor imaging. World Neurosurgery 73(1): 63-8; discussion e6, 2010.

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Last updated: 10/16/2015
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