Faculty & Staff
John A. Detre
Professor of Neurology
Director, Center for Functional Neuroimaging
Department: Neurology
Contact information
3 W Gates Building
3400 Spruce Street
Office: 517 Goddard Labs
Philadelphia, PA 19104
3400 Spruce Street
Office: 517 Goddard Labs
Philadelphia, PA 19104
Office: (215) 349-8465
Fax: (215) 614-1927
Lab: (215) 574-8487
Fax: (215) 614-1927
Lab: (215) 574-8487
Email:
DETRE@MAIL.MED.UPENN.EDU
DETRE@MAIL.MED.UPENN.EDU
Graduate Group Affiliations
Publications
Education:
B.S. (Chemistry)
Yale University , 1981.
M.D.
Yale University, 1986.
B.S. (Chemistry)
Yale University , 1981.
M.D.
Yale University, 1986.
Post-Graduate Training
Intern in Medicine, University Health Ctr. of Pittsburgh, PA, 1986-1987.
Research Fellow, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, 1987-1989.
Research Fellow, Department of Biochemistry/Biophysics, University of Pennsylvania, Philadelphia, PA, 1989-1990.
Resident in Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, 1990-1993.
Intern in Medicine, University Health Ctr. of Pittsburgh, PA, 1986-1987.
Research Fellow, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, 1987-1989.
Research Fellow, Department of Biochemistry/Biophysics, University of Pennsylvania, Philadelphia, PA, 1989-1990.
Resident in Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA, 1990-1993.
Certifications
American Board of Neurology and Psychiatry, 1994.
Permanent linkAmerican Board of Neurology and Psychiatry, 1994.
Description of Research Expertise
KEY WORDS:magnetic resonance, brain mapping, cerebral blood flow, brain injury
RESEARCH INTERESTS
Physiology and pathophysiology of functional activation. Clinical and translational neuroimaging. Imaging in stroke. Imaging in epilepsy. Imaging of recovery of function. Imaging in sleep research.
RESEARCH TECHNIQUES
Magnetic resonance imaging and spectroscopy with an emphasis on magnetic resonance techniques used to image brain function in addition to brain structure. Optical spectroscopy and imaging.
RESEARCH SUMMARY
Overall research focuses on cerebral blood flow and metabolism under normal and conditions and in response to brain injury. Specific conditions under investigation include functional activation of human brain in response to cognitive and sensorimotor tasks, epilepsy, cerebrovascular disease, and strokes. This research primarily utilizes magnetic resonance techniques including functional imaging techniques and spectroscopy, often correlated with other methods. There is a large component of data analysis and processing using statistical parametric mapping and other computational methods. In addition, the physiological basis and pathophysiological influences on functional activation are studied using a rat model. The research is carried out in collaboration with investigators from Radiology Research, the Cerebrovascular Research Center, Cognitive Neurology, and the Epilepsy Center.
