Faculty & Staff
Moses Morakortoi Darpolor, Ph.D.
Research Associate of Radiology
Department: Radiology
Contact information
University of Pennsylvania
Department of Radiology
B-6 Blockley Hall - 6021
423 Guardian Drive
Philadelphia, PA 19104
Department of Radiology
B-6 Blockley Hall - 6021
423 Guardian Drive
Philadelphia, PA 19104
Office: (215)746-7387
Email:
darpolor@mail.med.upenn.edu
darpolor@mail.med.upenn.edu
Education:
A.S. (Biological Sciences)
Midland College, 1997.
B.S. (Chemistry & Mathematics)
Angelo State University, 1999.
Post-B.S. (Biomedical Engineering)
Milwaukee School of Engineering, 2001.
Ph.D. (Biomedical Engineering (Functional Imaging))
Marquette University & Medical College of Wisconsin, 2006.
A.S. (Biological Sciences)
Midland College, 1997.
B.S. (Chemistry & Mathematics)
Angelo State University, 1999.
Post-B.S. (Biomedical Engineering)
Milwaukee School of Engineering, 2001.
Ph.D. (Biomedical Engineering (Functional Imaging))
Marquette University & Medical College of Wisconsin, 2006.
Post-Graduate Training
Medical Physics, Memorial Sloan-Kettering Cancer Center, 2006-2008.
Radiology, Stanford University Medical Center, 2008-2010.
Radiology, University of Pennsylvania, 2010-2011.
Permanent linkMedical Physics, Memorial Sloan-Kettering Cancer Center, 2006-2008.
Radiology, Stanford University Medical Center, 2008-2010.
Radiology, University of Pennsylvania, 2010-2011.
Description of Research Expertise
Research interests involve the investigation of crucial metabolic signatures, bioenergetic status, and functional perfusion of cancer in vivo. The studies are performed with the utility of hyperpolarized [1-13C]pyruvate magnetic resonance spectroscopic imaging (MRSI), 1H-decoupled 31P MRSI, and Dynamic Contrast-Susceptibility (DSC) MRI. Preclinical models studied are 9L gliasarcoma, HCT-116, Morris hepatoma, follicular lymphoma (WSU-FSCCL). The utility of hollow-fiber bioreactor perfusion system is implemented to investigate the mechanisms of action of new target agents or novel combination therapy.Selected Publications
Darpolor Moses M, Molthen Robert C, Schmainda Kathleen M: Multimodality imaging of abnormal vascular perfusion and morphology in preclinical 9L gliosarcoma model. PloS one 6(1): e16621, Jan 2011.Darpolor Moses M, Yen Yi-Fen, Chua Mei-Sze, Xing Lei, Clarke-Katzenberg Regina H, Shi Wenfang, Mayer Dirk, Josan Sonal, Hurd Ralph E, Pfefferbaum Adolf, Senadheera Lasitha, So Samuel, Hofmann Lawrence V, Glazer Gary M, Spielman Daniel M: In vivo MRSI of hyperpolarized [1-(13)C]pyruvate metabolism in rat hepatocellular carcinoma. NMR in biomedicine Dec 2010.
Moses M. Darpolor, Peter T. Kennealey, H. Carl Le, Kristen L. Zakian, Ellen Ackerstaff, Asif Rizwan, Jin-Hong Chen, Elliot B. Sambol, Gary K. Schwartz, Samuel Singer and Jason A. Koutcher: Preclinical study of treatment response in HCT-116 cells and xenografts with 1H-decoupled 31P MRS. NMR in biomedicine Dec 2010.
Wu Hsiang-En, Sun Han-Sen, Darpolar Moses, Leitermann Randy J, Kampine John P, Tseng Leon F: Dynorphinergic mechanism mediating endomorphin-2-induced antianalgesia in the mouse spinal cord. The Journal of pharmacology and experimental therapeutics 307(3): 1135-41, Dec 2003.
Wu Hsiang-En, Darpolor Moses, Nagase Hiroshi, Tseng Leon F: Acute antinociceptive tolerance and partial cross-tolerance to endomorphin-1 and endomorphin-2 given intrathecally in the mouse. Neuroscience letters 348(3): 139-42, Sep 2003.
Wu Hsiang-en, Sun Han-Sen, Darpolar Moses, Dunn William, Tseng Leon F: Antinociceptive properties of oxymorphazole in the mouse. European journal of pharmacology 473(2-3): 143-8, Jul 2003.
