Dr. Cormode's research focuses on the development of novel and multifunctional nanoparticle contrast agents for medical imaging applications. A current major area is the development of gold and bismuth nanoparticles as contrast agents for computed tomography (CT). The nanoparticles can be further modified to have a variety of additional functional properties, such as fluorescence, MRI contrast or therapeutic effects. Related areas of interest are novel computed tomography-based imaging methods, such as dual energy CT, spectral CT and iterative image reconstruction. These technologies are being applied for structural imaging and molecular imaging of the levels of specific cell types and proteins in vivo. These approaches provide enhanced characterization of cardiovascular diseases and cancers, which should allow improved selection of therapies and monitoring of response to treatments.
Undergraduates and master's students, as well as prospective graduate students and postdoctoral fellows are encouraged to email Dr. Cormode if interested in working in our lab.
Naha, Pratap C.; Lau, Kristen C.; Hsu, Jessica, C.; Hajfathalian, Maryam; Mian, Shaameen; Chhour, Peter; Uppulari, Lahari; MacDonald, Elizabeth S.; Maidment, Andrew D. A.; Cormode, David P.: Gold silver alloy nanoparticles (GSAN): an imaging probe for breast cancer screening with dual-energy mammography or computed tomography. Nanoscale 8: 13740–13754, September 2016.
Cheheltani, Rabee; Ezzibdeh, Rami M.; Chhour, Peter; Chandrika, Kumudini; Jurcova, Martina; Blundell, Cassidy; Litt, Harold I.; Ferrari, Victor A.; Allcock, Harry A.; Sehgal, Chandra M.; Cormode, David P. : Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging. Biomaterials 102: 87-97, September 2016.
Bernstein, Ally L.; Dhanantwari, Amar; Jurcova, Martina; Cheheltani, Rabe’e; Naha, Pratap C.; Ivanc, Thomas; Shefer, Efrat; Cormode, David P.: Effect of iterative model-based reconstruction on the sensitivity of computed tomography towards iodine and gold nanoparticle contrast agents. Scientific Reports 6: 26177, May 2016.
Chhour, Peter; Naha, Pratap C.; O’Neill, Sean M.; Litt, Harold I.; Reilly, Muredach P.; Ferrari, Victor A.; Cormode, David P.: Labeling monocytes with gold nanoparticles to track their recruitment in atherosclerosis with computed tomography. Biomaterials 82: 93-103, May 2016.
Naha, Pratap C.; Chhour, Peter; Cormode, David P.: Systematic in vitro toxicological screening of gold nanoparticles designed for nanomedicine applications. Toxicology in Vitro 29: 1445-1453, October 2015.
Naha, Pratap C.; Al-Zaki, Ajlan; Hecht, Elizabeth; Chorny, Michael; Chhour, Peter; Blankemeyer, Erik; Yates, Douglas M.; Witschey, Walter W. T.; Litt, Harold I.; Tsourkas, Andrew; Cormode, David P.: Dextran coated bismuth-iron oxide nanohybrid contrast agents for computed tomography and magnetic resonance imaging. J. Mater. Chem. B 2(46): 8239-8248, November 2014.
Chhour, Peter; Gallo, Nicolas; Cheheltani, Rabe’e; Williams, Dewight; Al-Zaki, Ajlan; Nichol, Jessica L.; Tian, Zhicheng; Paik, Taejong; Naha, Pratap C.; Witschey, Walter W. T.; Allcock, Harry R.; Murray, Chris B.; Tsourkas, Andrew; Cormode, David P.: Nano-disco balls: Control over surface versus core loading of diagnostically active nanocrystals into polymer nanoparticles. ACS Nano 8(9): 9143-9153, September 2014.
Brown, Anna L.; Naha, Pratap C.; Litt, Harold I.; Goforth, Andrea M. Cormode, David P.: Synthesis, X-ray Opacity, and Biological Compatibility of Ultra-High Payload Elemental Bismuth Nanoparticle X-ray Contrast Agents. Chemistry of Materials 26: 2266-2274, April 2014.
Allijn, Iris E.; Leong, Wei; Tang, Jun; Gianella, Anita; Mieszawska, Aneta J.; Fay, Francois; Ma, Ge; Russell, Stewart; Callo, Catherine B.; Gordon, Ronald E.; Korkmaz, Emine; Post, Jan Andries; Zhao, Yiming M.; Gerritsen, Hans C.; Thran, Axel; Proksa, Roland; Daerr, Heiner; Storm, Gert; Fuster, Valentin; Fisher, Edward A.; Fayad, Zahi A.; Mulder, Willem J.M.; Cormode, David P.: Gold nanocrystal labeled low density lipoprotein allows lipoprotein imaging from the macroscopic to subcellular level. ACS Nano 7(11): 9761-9770, November 2013.
Mieszawska, Aneta J.; Mulder, Willem J. M.; Fayad, Zahi A.; Cormode, David P.: Multifunctional gold nanoparticles for diagnosis and therapy of disease. Molecular Pharmaceutics 10: 831-847, 2013.
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Last updated: 08/05/2016
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