Faculty & Staff

David Peter Cormode, PhD

faculty photo
Assistant Professor of Radiology
Member, Institute for Translational Medicine and Therapeutics
Member, Center for Translational Targeted Therapeutics and Nanomedicine
Member, Center of Excellence in Environmental Toxicology
Member, Penn Institute for Immunology
Member, Nano/Bio Interface Center
Member, Penn Center for Musculoskeletal Disorders
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
3400 Spruce Street, 1 Silverstein
Philadelphia, PA 19104
Office: 215-615-4656
Education:
BA/MS (Chemistry)
St. Edmund Hall, University of Oxford, 2002.
PhD (Chemistry)
Balliol College, University of Oxford, 2006.
Post-Graduate Training
Postdoctoral Fellow , Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, 2006-2009.
Postdoctoral Fellow, American Heart Association Fellow, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, 2009-2010.
Postdoctoral Fellow, NIH ‘Pathway to independence’ K99 fellow, Translational and Molecular Imaging Institute, Mount Sinai School of Medicine , 2010-2012.
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Description of Research Expertise

Dr. Cormode's research focuses on the development of novel and multifunctional nanoparticle contrast agents for medical imaging applications. A current major area is the development of gold and bismuth nanoparticles as contrast agents for computed tomography (CT). The nanoparticles can be further modified to have a variety of additional functional properties, such as fluorescence, MRI contrast or therapeutic effects. Related areas of interest are novel computed tomography-based imaging methods, such as dual energy CT, spectral CT and iterative image reconstruction. These technologies are being applied for structural imaging and molecular imaging of the levels of specific cell types and proteins in vivo. These approaches provide enhanced characterization of cardiovascular diseases and cancers, which should allow improved selection of therapies and monitoring of response to treatments.

Undergraduates and master's students, as well as prospective graduate students and postdoctoral fellows are encouraged to email Dr. Cormode if interested in working in our lab.

Selected Publications

Naha, Pratap C.; Al-Zaki, Ajlan; Hecht, Elizabeth; Chorny, Michael; Chhour, Peter; Blankemeyer, Erik; Yates, Douglas M.; Witschey, Walter W. T.; Litt, Harold I.; Tsourkas, Andrew; Cormode, David P.: Dextran coated bismuth-iron oxide nanohybrid contrast agents for computed tomography and magnetic resonance imaging. J. Mater. Chem. B 2(46): 8239-8248, November 2014.

Swy, Eric R.; Schwartz-Duval, Aaron S.; Shuboni, Dorela D.; Latourette, Matthew T.; Mallet, Christiane L.; Parys, Maciej; Cormode, David P.; Shapiro. Erik M.: Dual-modality, fluorescent, PLGA encapsulated bismuth nanoparticles for molecular and cellular fluorescence imaging and computed tomography. Nanoscale 6(21): 13104-12, October 2014.

Chhour, Peter; Gallo, Nicolas; Cheheltani, Rabe’e; Williams, Dewight; Al-Zaki, Ajlan; Nichol, Jessica L.; Tian, Zhicheng; Paik, Taejong; Naha, Pratap C.; Witschey, Walter W. T.; Allcock, Harry R.; Murray, Chris B.; Tsourkas, Andrew; Cormode, David P.: Nano-disco balls: Control over surface versus core loading of diagnostically active nanocrystals into polymer nanoparticles. ACS Nano 8(9): 9143-9153, September 2014.

Brown, Anna L.; Naha, Pratap C.; Litt, Harold I.; Goforth, Andrea M. Cormode, David P.: Synthesis, X-ray Opacity, and Biological Compatibility of Ultra-High Payload Elemental Bismuth Nanoparticle X-ray Contrast Agents. Chemistry of Materials 26: 2266-2274, April 2014.

Chen, Lihong; Yang, Guangrui; Monslow, James; Hopper, Leslie; Cormode, David P.;Tang, Jun; Grant, Gregory R.; Tang, Soon Yew; Lawson, John A.; Pure, Ellen; FitzGerald, Garret A.: Myeloid cell microsomal PGE synthase-1 fosters atherogenesis in mice. Proceedings of the National Academy of Sciences of the USA 111(18): 6828-6833, May 2014.

Duivenvoorden, Raphael; Tang, Jun; Cormode, David P.; Mieszawska, Aneta J.; Izquierdo- Garcia, D.; Ozcan, Canturk; Otten, Maarten J.; Zaidi, Neeha; Lobatto, Mark E.; van Rijs, Sarian M.; Priem, Bram; Kuan, Emma L.; Martel, Catherine; Hewing, Bernd; Sager, Hendrik; Nahrendorf, Matthias; Randolph, Gwendalyn J.; Stroes, Erik S. G.; Fuster, Valentin; Fisher, Edward A.; Fayad, Zahi A.; Mulder, Willem J. M.: A statin-loaded reconstituted high-density lipoprotein nanoparticle as a targeted therapy for atherosclerotic plaque inflammation. Nature Communications 5: 3065, January 2014.

Allijn, Iris E.; Leong, Wei; Tang, Jun; Gianella, Anita; Mieszawska, Aneta J.; Fay, Francois; Ma, Ge; Russell, Stewart; Callo, Catherine B.; Gordon, Ronald E.; Korkmaz, Emine; Post, Jan Andries; Zhao, Yiming M.; Gerritsen, Hans C.; Thran, Axel; Proksa, Roland; Daerr, Heiner; Storm, Gert; Fuster, Valentin; Fisher, Edward A.; Fayad, Zahi A.; Mulder, Willem J.M.; Cormode, David P.: Gold nanocrystal labeled low density lipoprotein allows lipoprotein imaging from the macroscopic to subcellular level. ACS Nano 7(11): 9761-9770, 2013.

Mieszawska, Aneta J.; Mulder, Willem J. M.; Fayad, Zahi A.; Cormode, David P. : Multifunctional gold nanoparticles for diagnosis and therapy of disease. Molecular Pharmaceutics 10: 831-847, 2013.

Cormode, David P.; Roessl, Ewald; Thran, Axel; Skajaa, Torjus; Gordon, Ronald E.; Schlomka, Jens-Peter; Fuster, Valentin; Fisher, Edward A.; Mulder, Willem J. M.; Proksa, Roland; Fayad, Zahi A.: Multicolor computed tomography and targeted gold nanoparticles for analysis of atherosclerotic plaque composition. Radiology 256: 675-676, 2010.

Cormode, David P.; Skajaa, Torjus; van Schooneveld, Matti M.; Koole, Rolf; Jarzyna, Peter; Lobatto, Mark E.; Calcagno, Claudia; Barazza, Alessandra; Gordon, Ronald E.; Zanzonico, Pat; Fisher, Edward A.; Fayad, Zahi A. Mulder, Willem J. M.: Nanocrystal core high-density lipoproteins: A multimodal molecular imaging contrast agent platform. Nano Letters 8(11): 3715-3723, 2008.

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Last updated: 12/12/2014
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