Faculty & Staff

Robert H Mach, Ph.D.

faculty photo
Britton Chance Professor of Radiology
Director, Radiochemistry Research, Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania
Department: Radiology

Contact information
Department of Radiology
Chemistry Building
231 S. 34th Street
Philadelphia, PA 19104
Office: 215-746-8233
Graduate Group Affiliations
B.A. (Chemistry)
State University of New York, College at Potsdam, 1978.
Ph.D. (Medical Chemistry)
State University of New York at Buffalo, Buffalo, NY, 1985.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Chen DL, Zhou D, Chu W, Herrbirch P, Engle JT, Griffin E, Jones LA, Rothfuss JM, Geraci M, Hotchkiss RS, Mach RH: Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody. Nuclear Medicine and Biology 39: 137-144, 2012.

Lee H, Chen, DL, Rothfuss JM, Welch MJ, Gropler RJ, Mach RH: Synthesis and evaluation of 18F-labeled PPARγ antagonists. Nuclear Medicine and Biology 39: 77-87, 2012.

Wang Y, Xu J, Xia X, Yang M, Vangveravong S, Chen J, Mach RH, Xia Y: SV119-gold nanocage conjugates: a new platform for targeting cancer cells via sigma-2 receptors Nanoscale 4: 421-424, 2012.

Luedtke RR, Mishra Y, Wang Q, Griffin SA, Bell-Horner C, Taylor M, Vangveravong S, Dillon GH, Huang R-Q, Reichert DE, Mach RH: Comparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds. ACS Chemical Neuroscience 2012 Notes: in press.

Solingapuram Sai KK, Kil KE, Tu Z, Finck BN, Rothfuss JM, Shoghi KI, Welch MJ, Gropler RJ, Mach RH: Synthesis, radiolabeling and initial in vivo evaluation of [11C]KSM-01 for imaging PPAR-α receptors. Bioorganic & Medicinal Chemistry Letters 22: 6233-6236, 2012.

Zhou Dong, Chu Wenhua, Dence Carmen S, Mach Robert H, Welch Michael J: Highly efficient click labeling using 2-[¹⁸F]fluoroethyl azide and synthesis of an ¹⁸FN-hydroxysuccinimide ester as conjugation agent. Nuclear medicine and biology 39(8): 1175-81, Nov 2012.

Mach RH and Wheeler KT: Development of Radiotracers and Fluorescent Probes for Imaging Sigma-2 Receptors In Vitro and In Vivo. Targeted Molecular Imaging. Taylor & Francis,(13), 2012.

Dehdashti F, Laforest R, Gao F, Shoghi SI, Aft RL, Nussenbaum B, Kreisel FH, Bartlett NL, Cashen A, Wagner-Johnson N, Mach RH: Assessment of cellular proliferation in tumors by positron emission tomography using [18F]ISO-1. Journal of Nuclear Medicine 2012 Notes: in press.

Luedtke RR, Perez E, Yang S-H, Liu R, Vangveravong S, Tu Z, Mach RH, Simpkins JW: Neuroprotective effects of high affinity sigma-2 receptor selective compounds. Brain Research 1441: 17-26, 2012.

Zeng C, Rothfuss J, Zhang J, Chu W, Vangveravong S, Tu Z, Pan F, Chang KC, Hotchkiss R, Mach RH: Sigma-2 ligands induce tumor cell death by multiple signaling pathways British Journal of Cancer 106: 693-701, 2012.

back to top
Last updated: 08/25/2016
The Trustees of the University of Pennsylvania