Faculty & Staff

Chenbo Zeng, PhD

faculty photo
Research Assistant Professor of Radiology
Research Associate, University of Pennsylvania Perelman School of Medicine, Department of Radiology
Department: Radiology

Contact information
Department of Radiology
University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-746-2511
B.A. (Biochemistry)
Jilin University, Changchun, P.R. China, 1985.
M.S. (Biochemistry)
Jilin University, Changchun, P.R. China, 1988.
Ph.D (Biochemistry)
Iowa State University, Ames, Iowa, 1996.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Studying the biological functions of the sigma-2 receptor in breast cancer and in the central nervous system

Selected Publications

Zeng, C.,Rothfuss, J.M., Zhang, J., Vangveravong, S., Chu, W.,Li, S., Tu, Z., Xu, J., Mach, R.H.: Functional assays to define agonists and antagonists of the sigma-2 receptor. Anal Biochem. 448C:68-74, 2014.

Zeng, C., Vangveravong, S., McDunn, J.E., Hawkins, W. G., Mach, R.H.: Sigma-2 receptor ligand as a novel method for delivering a SMAC mimetic drug for treating ovarian cancer. Br J Cancer 109:2368-2377, 2013.

Mach, R.H., Zeng, C., Hawkins, W. G.: A novel protein for the imaging and treatment of cancer. J Med Chem. 56:7137-7160, 2013.

Spitzer, D., Simon, PO Jr, Kashiwagi, H., Xu, J., Zeng, C., Vangveravong, S., Zhou, D., Chang, K., McDunn, J.E., Hornick, J.R., Goedegebuure, P., Hotchkiss, R.S., Mach, R.H., Hawkins, W.G.: Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling. Cancer Res. 72:201-209, 2012.

Zeng, C., Rothfuss, J., Zhang,J., Chu, W., Vangveravong, S., Tu, Z., Pan, F., Chang, K.C., Hotchkiss, R., Mach, R.H. : Sigma-2 ligands induce tumor cell death by multiple signaling pathways. Br J Cancer 106:693-701, 2012.

Zeng, C., Vangveravong, S., Jones, L.A., Hyrc, K., Chang, K.C., Xu, J., Rothfuss, J.M., Mark P. Goldberg, M.P., Hotchkiss, R.S., and Robert H. Mach, R.H.: Characterization and evaluation of two novel fluorescent sigma-2 receptor ligands as proliferation probes. Molecular Imaging 10, 420-433, 2011.

Xu, J., Zeng, C., Chu, W., Pan, F., Rothfuss, J., Zhang, F., Tu, Z., Zhou, D., Zeng, D., Vangveravong, S., Johnston, F., Spitzer, D., Chang, K. C., Hotchkiss, R. S., Hawkins, W. G., Wheeler, K. T., and Mach, R. H.: Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun 2, 380, 2011.

Haller, J.L., Panyutin, I., Chaudhry, A., Zeng, C., Mach, R.H., Frank, J.A. : Sigma-2 receptor as potential indicator of stem cell differentiation. Mol Imaging Biol. 14:325-335, 2011.

Zeng, C., Pan,F., Jones, L.A., Lim, M.M., Griffin, E.A., Sheline, Y.I., Mintun, M.A., Holtzman, D.M., Mach, R.H.: Evaluation of 5-ethynyl-2’-deoxyruidine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system. Brain Res 1319, 21-32, 2010.

Mach, R.H., Zeng, C., Tu, Z., Jones, L.A., & Wheeler, K.T.: Molecular probes for imaging the sigma-2 receptor: A receptor-based biomarker of cell proliferation. Recent Advances of Bioconjugation Chemistry in Molecular Xiaoyuan Chen (eds.). Kerala, India: Research Signpost, 261-282, 2008.

back to top
Last updated: 03/10/2015
The Trustees of the University of Pennsylvania