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Chenbo Zeng, PhD

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Research Assistant Professor of Radiology
Department: Radiology

Contact information
Department of Radiology
University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-746-2511
B.A. (Biochemistry)
Jilin University, Changchun, P.R. China, 1985.
M.S. (Biochemistry)
Jilin University, Changchun, P.R. China, 1988.
Ph.D (Biochemistry)
Iowa State University, Ames, Iowa, 1996.
Post-Graduate Training
research associate, Division of Molecular Oncology, Washington University School of Medicine, St. Louis, MO, 1997-1999.
Research Associate, Renal Division, Washington University School of Medicine, St. Louis, MO, 1999-2001.
Research Associate , Department of Neurology, Washington University School of Medicine, St. Louis, MO, 2002-2004.
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Description of Research Expertise

Studying the biological functions of the sigma-2 receptor in breast cancer and in the central nervous system

Selected Publications

Edmonds CE, Makvandi M, Lieberman BP, Xu K, Zeng C, Li S, Hou C, Lee H, Greenberg RA, Mankoff DA, Mach RH.: [(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer. Am J Nucl Med Mol Imaging. 6: 94-101, 2016.

Makvandi M, Xu K, Lieberman BP, Anderson RC, Effron SS, Winters HD, Zeng C, McDonald ES, Pryma DA, Greenberg RA, Mach RH.: A Radiotracer Strategy to Quantify PARP-1 Expression In Vivo Provides a Biomarker That Can Enable Patient Selection for PARP Inhibitor Therapy. Cancer Res. 76(15): 4516-24, 2016.

Zeng C, Garg N, Mach RH.: The PGRMC1 Protein Level Correlates with the Binding Activity of a Sigma-2 Fluorescent Probe (SW120) in Rat Brain Cells. Mol Imaging Biol. 18: 172-9, 2016.

Makvandi M, Tilahun ED, Lieberman BP, Anderson RC, Zeng C, Xu K, Hou C, McDonald ES, Pryma DA, Mach RH.: The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer. Biochem Biophys Res Commun 467: 1070-5, 2015

Elizabeth S. McDonald, Chenbo Zeng, David A Mankoff, Andrew Kossenkov, Robert H Mach: PGRMC1 expression is significantly up-regulated in triple negative breast cancer in vivo with associated activation of cyclin D1 target genes: Analysis of 1019 invasive breast cancers in the TCGA database. 2015 Annual Meeting American Association for Cancer Research 2015.

Chenbo Zeng, Julia Mankoff and Rober H. Mach: Sigma-2 ligands sensitize triple negative breast cancer cells to PARP inhibitor treatment 2015 Annual Meeting American Association for Cancer Research 2015.

Zeng, C.,Rothfuss, J.M., Zhang, J., Vangveravong, S., Chu, W.,Li, S., Tu, Z., Xu, J., Mach, R.H.: Functional assays to define agonists and antagonists of the sigma-2 receptor. Anal Biochem. 448C:68-74, 2014.

Garg G, Vangveravong S, Zeng C, Collins L, Hornick M, Hashim Y, Piwnica-Worms D, Powell MA, Mutch DG, Mach RH, Hawkins WG1, Spitzer D.: Conjugation to a SMAC mimetic potentiates sigma-2 ligand induced tumor cell death in ovarian cancer. Mol Cancer 2014.

Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, Mach RH, Craven R, Head E, LeVine H 3rd, Spires-Jones TL, Catalano SM.: Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. PLoS One 9, 2014.

Bai S, Li S, Xu J, Peng X, Sai K, Chu W, Tu Z, Zeng C, Mach RH.: Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands. J Med Chem. 57(10): 4239-51, 2014.

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Last updated: 08/26/2016
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