Faculty & Staff

Alexander Shestov, Ph.D.

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Adjunct Assistant Professor of Radiology
Senior Research Investigator, University of Pennsylvania, Department of Radiology
Department: Radiology

Contact information
The University of Pennsylvania, Perelman School of Medicine
Department of Radiology, Molecular Imaging Section, Computational Biology
B6 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: 215-898-1805
Lab: 215-898-1805
B.S, M.S. (Biochemistry/Physical Chemistry)
Novosibirsk State University (Russia), 1980.
Ph. D. (Physical Chemistry/Chem.Eng.)
Boreskov Institute of Catalysis Russian Academy of Sciences, 1993.
B.S, M.S. (Mathematics)
Kemerovo State University, Institute of Mathematics RAS (Russia), 1994.
Post-Graduate Training
Visiting Fellow, Isotope Kinetics and Modeling, Institute of Isotopes of the Hungarian Academy of Sciences, Budapest, Hungary , 1988-1988.
Max-Plank-Society Fellow, Physical Chemistry, Max-Plank Institute, Mulheim-Ruhr, Germany , 1995-1996.
Royal Society-NATO Fellow, Math.Modeling, Isotope Kinetics, The University of Reading, Reading, UK , 1998-1999.
Academic Fellow, Mathematical Modeling, The Universities of Reading and Belfast, UK, 1999-2000.
SABIT Fellow, Computer Science, Modeling, The University of Michigan, Dep. of Computer Science, USA, 2001-2001.
Research Fellow, Molecular Dynamics and Quantum Chemistry, The Catholic University of America, DC, USA, 2002-2002.
Research Fellow, Brain Metabolism and Metabolic Modeling, University of Minnesota, USA, 2004-2005.
NIH, "Isotope Tracer Techniques to Study Metabolism In Vivo", 2005.
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Description of Research Expertise

Metabolic modeling, Metabolic Network Analysis, computational systems biology, quantitative cancer metabolism, brain metabolism, Metabolic Flux Analysis, metabolomics, fluxomics, bioinformatics, Metabolic Control Analysis, 13C MRS, LC-MS, catalysis, chemical kinetics, chemical engineering

Selected Publications

Brice Tiret, Alexander A. Shestov, Julien Valette, Pierre-Gilles Henry: Metabolic modeling of dynamic 13C NMR isotopomer data in the brain in vivo: Fast screening of metabolic models using automated generation of differential equations. Neurochem Res 2015.

Seung-Cheol Lee, Jeffrey Roman, Kavindra Nath, David Nelson, Kevin Muriuki, Alexander Shestov, and Jerry Glickson: 13C NMR studies of lymphoma and melanoma cells in the perfusion bioreactor and in vivo xenografts for flux calculation. Abstract Book, ISMRM 2015, Toronto, Canada. ISMRM, 2015.

Alexander A. Shestov, Anthony Mancuso, Pierre-Gilles Henry, Dennis B. Leeper, Jerry D. Glickson: 13C MRS/Bioreactor Technique to Study Melanoma: Quantifying Glutaminolysis and de novo Lipogenesis. Abstract Book, ISMRM 2015, Toronto, Canada. ISMRM, 2015.

Liu X, Shestov A.A., Locasale J.W. : Characterizing Human colon cancer cell lines: mass-isotopomer analysis. The 62nd American Society for Mass Spectrometry Conference, June 15-19, 2014, Baltimore, MD, USA ASMS, 2014.

Mehrmohamadi M, Liu X, Shestov AA, Locasale J.W. : Characterization of the usage of the serine metabolic network in human cancer. Cell Reports, 9(4), 1507-19 Page: 1507-19, 2014.

Shestov A.A, Liu X., Ser Z., Cluntun A., Hung Y.P., Huang L., Kim D., Le A., Yellen G., Albeck J.G., Locasale J.W. : Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. eLife, Jul 9;3 2014.

Shestov A.A., Mancuso A., Locasale J.W., Glickson J.D. : Human melanoma metabolic network analysis with combined 13C NMR/bioreactor technique: testing the Warburg effect. Experimental Biology Annual Meeting, April 24-28, 2013, Boston, MA, USA. FASEB, 2013.

Jeffrey F.M., Marin-Valencia I, Good L., Shestov A.A., Pascual J., Henry P-G., Malloy C.R. : Modeling of Brain Metabolism and Pyruvate Compartmentation Using 13C NMR In Vivo: Caution Required. J Cereb Blood Flow Metab. 2013 Aug, 33(8), 1160-7 2013.

Shestov A.A., Mancuso A., Locasale J.W., Glickson J.D. : Human melanoma 13C metabolic network analysis: quantifying the Warburg effect. The 3rd Translational Research in Mitochondria, Aging and Disease Symposium, October 2013, Philadelphia, USA 2013.

Simões R.V., Ackerstaff E., Shestov A.A., Serganova I., Kruchevsky N., Sukenick G., Blasberg R.G., and Koutcher J.A. : Metastatic breast cancer cells have higher mitochondrial function than isogenic non-metastatic cells. 21th ISMRM Scientific Meeting and Exhibition, April 2013, Salt Lake City, USA ISMRM (eds.). 2013.

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Last updated: 06/17/2015
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