Faculty & Staff

Alexander Shestov, Ph.D.

faculty photo
Adjunct Assistant Professor of Radiology
Senior Research Investigator, University of Pennsylvania, Department of Radiology
Department: Radiology

Contact information
The University of Pennsylvania, Perelman School of Medicine
Department of Radiology, Molecular Imaging Section, Computational Biology
B6 Blockley Hall
423 Guardian Drive
Philadelphia, PA 19104
Office: 215-898-1805
Lab: 215-898-1805
Education:
B.S, M.S. (Biochemistry/Physical Chemistry)
Novosibirsk State University (Russia), 1980.
Ph. D. (Physical Chemistry/Chem.Eng.)
Boreskov Institute of Catalysis Russian Academy of Sciences, 1993.
B.S, M.S. (Mathematics)
Kemerovo State University, Institute of Mathematics RAS (Russia), 1994.
Post-Graduate Training
Visiting Fellow, Isotope Kinetics and Modeling, Institute of Isotopes of the Hungarian Academy of Sciences, Budapest, Hungary , 1988-1988.
Max-Plank-Society Fellow, Physical Chemistry, Max-Plank Institute, Mulheim-Ruhr, Germany , 1995-1996.
Royal Society-NATO Fellow, Math.Modeling, Isotope Kinetics, The University of Reading, Reading, UK , 1998-1999.
Academic Fellow, Mathematical Modeling, The Universities of Reading and Belfast, UK, 1999-2000.
SABIT Fellow, Computer Science, Modeling, The University of Michigan, Dep. of Computer Science, USA, 2001-2001.
Research Fellow, Molecular Dynamics and Quantum Chemistry, The Catholic University of America, DC, USA, 2002-2002.
Research Fellow, Brain Metabolism and Metabolic Modeling, University of Minnesota, USA, 2004-2005.
Certifications
NIH, "Isotope Tracer Techniques to Study Metabolism In Vivo", 2005.
Permanent link
 
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Description of Research Expertise

Metabolic modeling, Metabolic Network Analysis, computational systems biology, quantitative cancer metabolism, brain metabolism, Metabolic Flux Analysis, metabolomics, fluxomics, bioinformatics, Metabolic Control Analysis, 13C MRS, LC-MS, catalysis, chemical kinetics, chemical engineering

Selected Publications

Brice Tiret, Alexander A. Shestov, Julien Valette, Pierre-Gilles Henry: Metabolic modeling of dynamic 13C NMR isotopomer data in the brain in vivo: Fast screening of metabolic models using automated generation of differential equations. Neurochem Res 2015.

Shestov A.A, Liu X., Ser Z., Cluntun A., Hung Y.P., Huang L., Kim D., Le A., Yellen G., Albeck J.G., Locasale J.W. : Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step. eLife 2014.

Mehrmohamadi M, Liu X, Shestov AA, Locasale J.W. : Characterization of the usage of the serine metabolic network in human cancer. Cell Reports 2014.

Jeffrey F.M., Marin-Valencia I, Good L., Shestov A.A., Pascual J., Henry P-G., Malloy C.R. : Modeling of Brain Metabolism and Pyruvate Compartmentation Using 13C NMR In Vivo: Caution Required. J Cereb Blood Flow Metab. 2013 Aug, 33(8), 1160-7 2013.

Tzika A.A., Fontes-Oliveira C.C., Shestov A.A., Constantinou C., Psychogios N., Righi V., Mintzopoulos D., Busquets S., Lopez-Soriano F.J., Milot S., Lepine F., Mindrinos M.N., Rahme L.G. and Argiles J.M. : Skeletal muscle mitochondrial uncoupling in a murine cancer cachexia model. Int J Oncol. 2013.

Shestov AA, Mancuso A, Leeper DB, Glickson JD.: Metabolic network analysis of DB1 melanoma cells: how much energy is derived from aerobic glycolysis? Adv Exp Med Biol. 2013;765:265-71 2013.

Shestov A.A., Barker B., Gu Z., and Locasale J.W. : Computational Approaches for Understanding Energy Metabolism. Wiley Interdiscip Rev Syst Biol Med. 2013, 5,733-50 2013.

Shestov AA, Valette J, Deelchand DK, Ugurbil K, Henry P-G: Metabolic Modeling of Dynamic Brain 13C NMR Multiplet Data: Concepts and Simulations with a Two-Compartment Neuronal-Glial Model. Neurochem Res 2012,37, 2388 2012.

van de Ven KC, de Galan BE, van der Graaf M, Shestov AA, Henry PG, Tack CJ, Heerschap A.: Effect of acute hypoglycemia on human cerebral glucose metabolism measured by 13C magnetic resonance spectroscopy. Diabetes. 2011 May;60(5):1467-73. 2011.

Shestov AA, Emir UE, Kumar A, Henry PG, Seaquist ER, Öz G.: Simultaneous measurement of glucose transport and utilization in the human brain. Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E1040-9. 2011.

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Last updated: 05/19/2015
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