Penn Medicine
Help | Search | Site Map | Contact   
faculty photo

Bonnie Ky, MD, MSCE

Assistant Professor of Medicine
Department: Medicine

Contact information
Hospital of the University of Pennsylvania
11-105 Smilow Center for Translational Research
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-573-6606
Fax: 215-746-7415
Education:
BS (Chemical Engineering )
Massachusetts Institute of Technology, 1995.
MD (Medicine)
University of Pennsylvania, 2001.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 2009.
Post-Graduate Training
Intern in Medicine, Hospital of the University of Pennsylvania, Philadelphia, 2001-2002.
Resident in Medicine, Hospital of the University of Pennsylvania, Philadelphia, 2002-2004.
Fellowship in Cardiology, Hospital of the University of Pennsylvania, Philadelphia, 2004-2007.
Fellowship, Cardiology Noninvasive Research, Hospital of the University of Pennsylvania, Philadelphia, 2007-2008.
Certifications
Internal Medicine, American Board of Internal Medicine, 2004.
Level II Nuclear Cardiology, Certification Board of Nuclear Cardiology, 2007.
Cardiovascular Medicine, American Board of Internal Medicine, 2007.
Level III Echocardiography, National Board of Echocardiography, 2007.
Permanent link
 
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

My clinical expertise is in noninvasive imaging by echocardiography and the care of patients in cardio-oncology.

Description of Research Expertise

My research interests are in translational cardiovascular epidemiology with a focus on the study of novel signaling pathways and mechanisms in human heart failure, cardiac remodeling, and cancer therapy cardiotoxicity. Current areas of research include:

1) Neuregulin Signaling:
We are interested in defining the relevance of circulating neuregulin as it relates to human heart failure and cardiac remodeling. I am the principal investigator of a longitudinal study determining the association between circulating neuregulin levels and cardiac remodeling and clinical outcomes in the Penn Heart Failure Study and the Chronic Renal Insufficiency Cohort.


2) Mechanistic Biomarker Studies in Cancer Therapy Cardiotoxicity:
We are interested in defining novel circulating biomarkers and genetic variations predictive of cancer therapy cardiotoxicity. Our objective is to gain mechanistic and translational insight into the pathophysiology of this disease. We have ongoing studies in specific pathways and biomarkers of interest, as well as proteomics discovery across various cardiotoxic regimens.


3) Myocardial Mechanics in Cancer Therapy Cardiotoxicity and Heart Failure:
We are interested in gaining insight into alterations in myocardial mechanics and sensitive measures of cardiac function, as defined by echocardiography, in patients exposed to cardiotoxic chemotherapy regimens as well as patients with chronic heart failure.

Selected Publications

Zhang KW, Finkelman BS, Gulati G, Narayan HK, Upshaw J, Narayan V, Plappert T, Englefield V, Smith AM, Zhang C, Hundley WG, Ky B: Abnormalities in Three-Dimensional Left Ventricular Mechanics with Anthracycline 1 Chemotherapy are Associated with Systolic and Diastolic Dysfunction. Journal of the American College of Cardiology Imaging 2018 Notes: Manuscript accepted, 2018.

Khouri MG, Ky B, Dunn G, Plappert T, Englefield V, Rabineau D, Yow E, Barnhart HX, St John Sutton M, Douglas PS : Echocardiography Core Lab Reproducibility of Cardiac Safety Assessments in Cardio-Oncology. Journal of the American Society of Echocardiography December 2017 Notes: Manuscript accepted.

Truitt R, Mu A, Corbin EA, Vite A, Brandimarto J, Ky B, Margulies KB: Increased Afterload Augments Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model. JACC Basic Translational Science December 2017 Notes: Manuscript accepted.

Waxman AJ, Clasen S, Hwang WT, Garfall A, Vogl DT, Carver J, O'Quinn R, Cohen AD, Stadtmauer E, Ky B, Weiss BM.: Carfilzomib-Associated Cardiovascular Adverse Events: A Systematic Review and Meta-Analysis. JAMA Oncology December 2017 Notes: epub ahead of print.

Grisham R, Ky B, Tewari KS, Chaplin DJ, Walker J: Clinical Trial Experience with CA4P Anticancer Therapy: Focus on Cardiovascular Adverse Events and Their Management. Gynecologic Oncology Research December 2017 Notes: Manuscript accepted.

Zhao H, O’Quinn R, Ambrose M, Jagasia D, Ky B, Wald J, Ferrari V, Kirkpatrick J, and Han Y: Contrast Echocardiography Provides the Greatest Impact in Patients with Reduced Ejection Fraction. Journal of the American Society of Echocardiography October 2017 Notes: epub ahead of print.

Brown J, Rickels M, Troxel A, Zemel B, Damjanov N, Ky B, Rhim A, Rustgi A, Courneya KS, Schmitz K: Dose-response effects of exercise on insulin among colon cancer survivors. Endocrine Related Cancer October 2017 Notes: Epub ahead of print.

Brown JC, Zemel BS, Troxel AB, Rickels MR, Damjanov N, Ky B, Rhim AD, Rustgi AK, Courneya KS, Schmitz KH: Dose-response Effects of Aerobic Exercise on Body Composition Among Colon Cancer Survivors: A Randomised Controlled Trial. British Journal of Cancer September 2017 Notes: Epub Ahead of Print doi: 10.1038/bjc.2017.339.

Wells QS, Veatch OJ, Fessel JP, Joon AY, Mosley JD, Held EP, Lindsay CS, Shaffer CM, Weeke P, Van Driest SL, Karnes JH, Blair MA, Lagrone LW, Su YR, Bowton EA, Feng Z, Ky B, Lenihan DJ, Fisch MJ, Denny JC, and Roden DM: Genome-Wide Association and Pathway Analysis of Left Ventricular Function After Anthracycline Exposure in Adults. Pharmacogenetics and Genomics 27(7): 247-254, Jul 2017.

Finkelman B, Putt M, Wang T, Wang L,Narayan H, Domchek S, DeMichele A, Fox K, Matro J, Shah P, Clark A, Bradbury A, Narayan V, Carver JR, Tang W, Ky B: Arginine-Nitric Oxide Metabolites and Cardiac Dysfunction in Patients With Breast Cancer. Journal of the American College of Cardiology 70(2): 152-162, July 2017.

back to top
Last updated: 01/09/2018
The Trustees of the University of Pennsylvania
 
© The Trustees of the University of Pennsylvania. Site best viewed with Mozilla, NN, IE, or Safari.
SOM Home International Programs Penn Alumni Clinical Trials Centers and Institutes Departments Faculty Research Education Administration