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J. Eduardo Rame, MD, MPhil

Associate Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Penn Medicine
Heart Failure, Mechanical Assist and Cardiac Transplant Center
Hospital of the University of Pennsylvania
2 East, Perelman Center for Advanced Medicine
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-615-7949
Fax: 215-349-5603
B.S., M.S. (Molecular Biophysics and Biochemistry)
Yale College, 1990.
M.Phil (Statistics/Health Services Research)
Oxford University , 1996.
M.D. (Medicine)
Harvard Medical School , 1997.
Post-Graduate Training
Intern in Internal Medicine, University of Texas Southwestern, 1997-1998.
Resident in Internal Medicine, University of Texas Southwestern, 1998-2000.
Fellow in Cardiovascular Genomics, University of Texas Southwestern, 2000-2002.
Fellow in Cardiology, Johns Hopkins University School of Medicine and Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health , 2002-2004.
Fellow in Heart Failure/Heart Transplant, Johns Hopkins Hospital, 2004-2005.
American Board of Internal Medicine (Internal Medicine), 2000.
American Board of Internal Medicine (Cardiovascular Disease), 2005.
American Board of Internal Medicine (Certification in Advanced Heart Failure and Cardiac Transplantation patients), 2010.
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Description of Clinical Expertise

I am cardiovascular specialist in the area of cardiomyopathy, chronic heart faiure, and pulmonary hypertension, focusing my clinical efforts in the more advanced stage of right and left heart failure syndromes. I am the current medical director of the mechanical circulatory support device program at the University of Pennsylvania and the clinical expertise that I bring to this program specifically involves phenotyping right ventricular function and right ventricular reserve in chronic heart failure. As a practitioner in various disease states causing pulmonary hypertension, I also have developed an expertise in characterizing right ventricular dysfunction due to RV-PA uncoupling in high pulmonary afterload syndrome (PAH).

In the area of advanced heart failure and Left ventricular assist device support (LVAD), I also bring a specialized program of myocardial recovery by optimizing the degree of mechanical unloading with a LVAD and maximizing the medical therapy that can be tolerated in an effort to drive the process of reverse myocardial remodeling to improve heart function. This is a highly specialized area in the field of advanced heart failure with only a handful of centers world-wide providing this therapeutic approach to their patients.

Description of Research Expertise

My role as an advanced heart failure clinician-scientist and director of the mechanical assist device program at Penn is to provide expertise in the area of myocardial failure in the more advanced stage of this syndrome. More recently I have been working on the emerging interface of metabolism and heart failure. The current focus of my research is the investigation of myocardial and systemic metabolism in the syndrome of chronic heart failure. Specifically, myocardial and systemic insulin resistance is being increasingly targeted as a mechanism of disease progression in chronic heart failure and the objectives as a translational researcher within my group have been to: 1. Understand the role of lipid and adipocytokine biology (leptin, adiponectin, resistin) in the emerging metabolic phenotype of heart failure; 2. Identify specific targets for improving myocardial energetics and whole-body metabolism in cardiomyopathic failure; and 3. Test the safety and efficacy through carefully designed pilot studies of “reversing” specific metabolic pathways which have been dysregulated in human heart failure. My collaborative network for this research currently includes the laboratories of Dr. Tim McGraw, Dr. Richard Shannon, Dr. Ken Margulies and Dr. Tom Cappola within my own group at Penn as well as the laboratory of Dr. Christian Schulze and Professor Ira Goldberg at Columbia University.

Selected Publications

Jason J. Han MD, Salman Zaheer MD, Rahul Kanade BA, Jennifer Chung MD, Carol W Chen MD, Ann C Gaffey MD, Christyna Justice RN, BSN, Alyse E Ameer BS, J. Eduardo Rame MD, Michael A. Acker MD, Pavan Atluri MD: Left Ventricular Assist Device Implantation Reduces Elevated Pulmonary Vascular Resistance in Patients Bridged to Heart Transplant Circulation Journal Epub ahead of Print, January 2018.

Edo Y. Birati, MD, Thomas C. Hanff, MD,Dawn Maldonado, MD, E. Wilson Grandin, MD, Peter J. Kennel, MD, Jeremy A. Mazurek, MD, Esther Vorovich, MD,Matthew Seigerman, MD, Jessica LL Howard, BS, Michael A. Acker, MD, Yoshifumi Naka, MD, Joyce Wald, DO, Lee R. Goldberg, MD MPH Mariell Jessup, MD, Pavan Atluri, MD, Kenneth B. Margulies, MD, P. Christian Schulze, MD and J. Eduardo Rame, MD MPhil1: Predicting Long Term Outcome in patients treated with Continuous Flow Left Ventricular Assist Device - The Penn - Columbia Risk Score. Journal of the American Heart Association Epub ahead of Print, January 2018.

J.Eduardo Rame and Robert Kormos: Adverse Events and Mitigation Strategies, Mechanical Circulatory Support. Braunwald's Mechanical Circulatory Support. Jim Kirklin and Eugene Braunwald (eds.). Elsevier, 2018.

Gopal Dipika J, Hanff Thomas C, Mazurek Jeremy A, Grandin Wilson E, Howard Jessica, Forde-McLean Rhondalyn, Wald Joyce, King Kathie, Acker Michael A, Goldberg Lee R, Jessup Mariell, Atluri Pavan, Margulies Kenneth B, Rame Eduardo J, Birati Edo Y: Prognostic Implications of Changes in Albumin Following Left Ventricular Assist Device Implantation in Patients With Severe Heart Failure. The American journal of cardiology 120(11): 2003-2007, Dec 2017.

Rene A Garvey, Desai Nimesh, Wald Joyce, Rame Jesus Eduardo, Frogel Jonathan K, Anwaruddin Saif: Transfemoral transcatheter aortic valve replacement with a self-expanding valve for severe aortic regurgitation in a patient with left ventricular assist device. Journal of cardiac surgery 32(11): 741-745, Nov 2017.

Arabía Francisco A, Milano Carmelo A, Mahr Claudius, McGee Edwin C, Mokadam Nahush A, Rame J Eduardo, Moriguchi Jaime D, Ramzy Danny, Naftel David C, Myers Susan L, Kirklin James K: Biventricular Support With Intracorporeal, Continuous Flow, Centrifugal Ventricular Assist Devices. The Annals of thoracic surgery Nov 2017.

Kiernan Michael S, Grandin E Wilson, Brinkley Marshall, Kapur Navin K, Pham Duc Thinh, Ruthazer Robin, Rame J Eduardo, Atluri Pavan, Birati Edo Y, Oliveira Guilherme H, Pagani Francis D, Kirklin James K, Naftel David, Kormos Robert L, Teuteberg Jeffrey J, DeNofrio David: Early Right Ventricular Assist Device Use in Patients Undergoing Continuous-Flow Left Ventricular Assist Device Implantation: Incidence and Risk Factors From the Interagency Registry for Mechanically Assisted Circulatory Support. Circulation. Heart failure 10(10), Oct 2017.

Keeshan Britton C, O'Connor Matthew J, Lin Kimberly Y, Monos Dimitrios, Lind Curt, Mascio Christopher E, Rame Jesus Eduardo, Spray Thomas L, Shaddy Robert E, Rossano Joseph W: Value of a flow cytometry cross-match in the setting of a negative complement-dependent cytotoxicity cross-match in heart transplant recipients. Clinical transplantation 31(10), Oct 2017.

Han Jason J, Chung Jennifer, Chen Carol W, Gaffey Ann C, Sotolongo Alex, Justice Christyna, Ameer Alyse E, Rame J Eduardo, Bermudez Christian, Acker Michael A, Atluri Pavan: Different Clinical Course and Complications in Interagency Registry for Mechanically Assisted Circulatory Support 1 Patients Managed With or Without Extracorporeal Membrane Oxygenation. ASAIO journal (American Society for Artificial Internal Organs : 1992) Sep 2017.

Enriquez Andres, Liang Jackson, Gentile Javier, Schaller Robert D, Supple Gregory E, Frankel David S, Garcia Fermin C, Wald Joyce, Birati Edo Y, Rame J Eduardo, Bermudez Christian, Callans David J, Marchlinski Francis E, Santangeli Pasquale: Outcomes of rescue cardiopulmonary support for periprocedural acute hemodynamic decompensation in patients undergoing catheter ablation of electrical storm. Heart rhythm Sep 2017.

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Last updated: 01/07/2018
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