Penn Cardiovascular Institute

Heart and Vascular Faculty

faculty photo

J. Eduardo Rame, M.D., M.Phil

Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Penn Medicine
Heart Failure, Mechanical Assist and Cardiac Transplant Center
Hospital of the University of Pennsylvania
2 East, Perelman Center for Advanced Medicine
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-615-7949
Fax: 215-349-5603
B.S., M.S. (Molecular Biophysics and Biochemistry)
Yale College, 1990.
M.Phil (Statistics/Health Services Research)
Oxford University , 1996.
M.D. (Medicine)
Harvard Medical School , 1997.
Post-Graduate Training
Intern in Internal Medicine, University of Texas Southwestern, 1997-1998.
Resident in Internal Medicine, University of Texas Southwestern, 1998-2000.
Fellow in Cardiovascular Genomics, University of Texas Southwestern, 2000-2002.
Fellow in Cardiology, Johns Hopkins University School of Medicine and Cardiovascular Branch, National Heart Lung and Blood Institute, National Institutes of Health , 2002-2004.
Fellow in Heart Failure/Heart Transplant, Johns Hopkins Hospital, 2004-2005.
American Board of Internal Medicine (Internal Medicine), 2000.
American Board of Internal Medicine (Cardiovascular Disease), 2005.
American Board of Internal Medicine (Certification in Advanced Heart Failure and Cardiac Transplantation patients), 2010.
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Description of Clinical Expertise

I am cardiovascular specialist in the area of cardiomyopathy, chronic heart faiure, and pulmonary hypertension, focusing my clinical efforts in the more advanced stage of right and left heart failure syndromes. I am the current medical director of the mechanical circulatory support device program at the University of Pennsylvania and the clinical expertise that I bring to this program specifically involves phenotyping right ventricular function and right ventricular reserve in chronic heart failure. As a practitioner in various disease states causing pulmonary hypertension, I also have developed an expertise in characterizing right ventricular dysfunction due to RV-PA uncoupling in high pulmonary afterload syndrome (PAH).

In the area of advanced heart failure and Left ventricular assist device support (LVAD), I also bring a specialized program of myocardial recovery by optimizing the degree of mechanical unloading with a LVAD and maximizing the medical therapy that can be tolerated in an effort to drive the process of reverse myocardial remodeling to improve heart function. This is a highly specialized area in the field of advanced heart failure with only a handful of centers world-wide providing this therapeutic approach to their patients.

Description of Research Expertise

My role as an advanced heart failure clinician-scientist and director of the mechanical assist device program at Penn is to provide expertise in the area of myocardial failure in the more advanced stage of this syndrome. More recently I have been working on the emerging interface of metabolism and heart failure. The current focus of my research is the investigation of myocardial and systemic metabolism in the syndrome of chronic heart failure. Specifically, myocardial and systemic insulin resistance is being increasingly targeted as a mechanism of disease progression in chronic heart failure and the objectives as a translational researcher within my group have been to: 1. Understand the role of lipid and adipocytokine biology (leptin, adiponectin, resistin) in the emerging metabolic phenotype of heart failure; 2. Identify specific targets for improving myocardial energetics and whole-body metabolism in cardiomyopathic failure; and 3. Test the safety and efficacy through carefully designed pilot studies of “reversing” specific metabolic pathways which have been dysregulated in human heart failure. My collaborative network for this research currently includes the laboratories of Dr. Tim McGraw, Dr. Richard Shannon, Dr. Ken Margulies and Dr. Tom Cappola within my own group at Penn as well as the laboratory of Dr. Christian Schulze and Professor Ira Goldberg at Columbia University.

Selected Publications

Ascheim DD, Gelijns AC, Goldstein D, Moye LA, Smedira N, Lee S, Klodell CT, Szady A, Parides MK, Jeffries NO, Skerrett D, Taylor DA, Rame JE, Milano C, Rogers JG, Lynch J, Dewey T, Eichhorn E, Sun B, Feldman D, Simari R, O'Gara PT, Taddei-Peters WC, Miller MA, Naka Y, Bagiella E, Rose EA, Woo YJ: Mesenchymal precursor cells as adjunctive therapy in recipients of contemporary left ventricular assist devices. Circulation 129(22): 2287-96, Jun 2014 Notes: Epub 2014 Mar 28.

Birati EY, Kirkpatrick JN, Rame JE, Bala R, Margulies KB.: Dynamic left ventricular assist device inflow obstruction. Circ Heart Fail 7(1): 225-6, Jan 2014

John R, Aaronson KD, Pae WE, Acker MA, Hathaway DR, Najarian KB, Slaughter MS; HeartWare Bridge to Transplant ADVANCE Trial Investigators: Drive-line infections and sepsis in patients receiving the HVAD system as a left ventricular assist device. J Heart Lung Transplant 33(10): 1066-73, Oct 2014.

Johnson NJ, Acker M, Hsu CH, Desai N, Vallabhajosyula P, Lazar S, Horak J, Wald J, McCarthy F, Rame E, Gray K, Perman SM, Becker L, Cowie D, Grossestreuer A, Smith T, Gaieski DF: Extracorporeal life support as rescue strategy for out-of-hospital and emergency department cardiac arrest. Resuscitation S0300-9572(14): 00730-8, Sept 2014 Notes: [Epub ahead of print]

Rame JE, Vaidya A : Disease Progression in Pulmonary Arterial Hypertension: Refining the Phenotype With a Prognostic Biomarker Profile From Collagen. JACC Heart Fail 2(4): 422-4, Aug 2014 Notes: Epub 2014 Jul 9.

Rame JE, Vaidya A: Disease Progression in Pulmonary Arterial Hypertension: Refining the Phenotype With a Prognostic Biomarker Profile From Collagen. JACC Heart Fail. In press: S2213-1779, July 2014.

Birati EY, Rame JE: Left ventricular assist device management and complications. Crit Care Clin 30(3): 607-27, July 2014.

Birati EY, Rame JE: Post–Heart Transplant Complications Critical Care Clinics Elsevier, 30(3): 629–637, July 2014.

Patel1 AM, Rame JE, Rudnick MR: How Does the Nephrologist Manage an LVAD Patient on Chronic Maintenance Dialysis? Seminars in Dialysis 27(3): 284–288, May–June 2014 Notes: Article first published online: 21 MAR 2014

Rame JE, Atluri P, Acker MA: Unexpected Abrupt Increase in Left Ventricular Assist Device Thrombosis N Engl J Med 370: 1466-1467, April 2014.

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Last updated: 12/08/2014
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